- document
-
Kuper, C.F. (author), van Zijverden, M. (author), Klaassen, C. (author), Tegelenbosch-Schouten, M. (author), Wolterbeek, A.P.M. (author), TNO Kwaliteit van Leven (author)The effects of cyclosporin A (CY) and cyclophosphamide (CPS) on Peyer's patches (PP) were studied in Wistar rats, exposed in utero and neonatally or during adult age. In one study, pregnant dams received 5 or 15 mg/kg bw/day CY from gestation day 6 to day 21 of lactation. In two other studies, animals were exposed at young adult age: female rats...article 2007
- document
-
Spaan, S. (author), Schinkel, J.M. (author), Wouters, I.M. (author), Preller, E.A. (author), Tjoe Nij, E.I.M. (author), Heederik, D. (author), Tielemans, E.L.J.P. (author), Preller, L. (author), TNO Kwaliteit van Leven (author)Endotoxin is a well-known toxin which has been associated with several health effects. Many factors influence airborne endotoxin exposure and can cause high variability in exposure between and within workers. Additionally, since the source of endotoxin exposure - gram-negative bacteria - grow and amplify, exposure variability is thought to be...article 2007
- document
-
van Boxtel, E.L. (author), van den Broek, L.A.M. (author), Koppelman, S.J. (author), Vincken, J.-P. (author), Gruppen, H. (author), TNO Kwaliteit van Leven (author)Mildly extracted peanut allergen Ara h 1 was previously reported to occur as an oligomeric complex. In this paper we describe how the protein in this oligomeric complex interacts noncovalently with phenolic compounds of the proanthocyanidin type. These interactions are being disrupted during anion exchange chromatography, resulting in the...article 2007
- document
-
Kudryashova, E.V. (author), Visser, A.J.W.G. (author), van Hoek, A. (author), de Jongh, H.H.J. (author), TNO Kwaliteit van Leven (author)To stabilize air-water interfaces, as in foams, the adsorption of surface-active components is a prerequisite. An approach to controlling the surface activity of proteins is noncovalent complex formation with a polyelectrolyte in the bulk phase. The molecular properties of egg white ovalbumin in a complex with pectin in the bulk solution and at...article 2007
- document
-
Mandjes, M. (author), Roijers, F. (author), TNO Informatie- en Communicatietechnologie (author)This paper studies a fluid queue with coupled input and output. Flows arrive according to a Poisson process, and when n flows are present, each of them transmits traffic into the queue at a rate c/(n+1), where the remaining c/(n+1) is used to serve the queue. We assume exponentially distributed flow sizes, so that the queue under consideration...article 2007
- document
-
Weijenberg, M.P. (author), Lüchtenborg, M. (author), de Goeij, A.F.P.M. (author), Brink, M. (author), van Muijen, G.N.P. (author), de Bruïne, A.P. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)Objective: To investigate baseline fat intake and the risk of colon and rectal tumors lacking MLH1 (mutL homolog 1, colon cancer, nonpolyposis type 2) repair gene expression and harboring mutations in the APC (adenomatous polyposis coli) tumor suppressor gene and in the KRAS (v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) oncogene....article 2007
- document
- Waarts, P.H. (author) article 2007
- document
- de Jonge, J.D. (author), Knippels, L.M.J. (author), Ezendam, J. (author), Odink, J. (author), Penninks, A.H. (author), van Loveren, H. (author), TNO Kwaliteit van Leven (author) article 2007
- document
-
Hawkins, R. (author), Ballon, P. (author), TNO Informatie- en communicatietechnologie (author)Purpose - This paper aims to explore the question: 'What is the relationship between standards and business models?' and illustrate the conceptual linkage with reference to developments in the mobile communications industry. Design/methodology/approach - A succinct overview of literature on standardization, business models and platform markets...article 2007
- document
-
Grootjen, M. (author), Lindenberg, J. (author), de Greef, T. (author), Neerincx, M.A. (author), TNO Defensie en Veiligheid (author)De laatste twintig jaar hebben grote veranderingen gebracht in de informatietechnologie. Aan boord van marineschepen zorgt de steeds verdergaande automatisering voor een ingrijpende wijziging in de functie van de operator op de brug, in de commandocentrale en in de technische centrale.article 2007
- document
-
Emeis, J.J. (author), Jirouskova, M. (author), Muchitsch, E.-M. (author), Shet, A.S. (author), Smyth, S.S. (author), Johnson, G.J. (author), TNO Preventie en Gezondheid (author)Murine blood coagulation factors and function are quite similar to those of humans. Because of this similarity and the adaptability of mice to genetic manipulation, murine coagulation factors and inhibitors have been extensively studied. These studies have provided significant insights into human hemostasis. They have also provided useful...article 2007
- document
-
Karnaukhova, E. (author), Ophir, Y. (author), Trinh, L. (author), Dalal, N. (author), Punt, P.J. (author), Golding, B. (author), Shiloach, J. (author), TNO Kwaliteit van Leven (author)Background: Human α1-proteinase inhibitor (α1-PI), also known as antitrypsin, is the most abundant serine protease inhibitor (serpin) in plasma. Its deficiency is associated with development of progressive, ultimately fatal emphysema. Currently in the United States, α1-PI is available for replacement therapy as an FDA licensed plasma-derived (pd...article 2007
- document
-
Beulens, J.W.J. (author), Rimm, E.B. (author), Hendriks, H.F.J. (author), Hu, F.B. (author), Manson, J.E. (author), Hunter, D.J. (author), Mukamal, K.J. (author), TNO Kwaliteit van Leven (author)OBJECTIVE - We sought to investigate whether a polymorphism in the alcohol dehydrogenase 1c (ADH1C) gene modifies the association between alcohol consumption and type 2 diabetes. RESEARCH DESIGN AND METHODS - In nested case-control studies of 640 women with incident diabetes and 1,000 control subjects from the Nurses' Health Study and 383 men...article 2007
- document
-
Drissen, R.E.T. (author), Maas, R.H.W. (author), van der Maarel, M.J.E.C. (author), Kabel, M.A. (author), Schols, H.A. (author), Tramper, J. (author), Beeftink, H.H. (author), TNO Kwaliteit van Leven (author)The kinetics of cellulose hydrolysis by commercially available Cellubrix were described mathematically, with Avicel and wheat straw as substrates. It was demonstrated that hydrolysis could be described by three reactions: direct glucose formation and indirect glucose formation via cellobiose. Hydrolysis did not involve any soluble oligomers...article 2007
- document
-
Bazalgette Courrèges-Lacoste, G. (author), Ahlers, B. (author), Pérez, F.R. (author), TNO Industrie en Techniek (author)Among the different instruments that have been pre-selected to be on-board the Pasteur payload on ExoMars is the Raman/laser induced breakdown spectroscopy (LIBS) instrument. Raman spectroscopy and LIBS will be integrated into a single instrument sharing many hardware commonalities. An international team under the lead of TNO has been gathered...article 2007
- document
- Anthony, S. (author), Hille, E.T.M. (author), van der Pal-de Bruin, K.M. (author), Verloove-Vanhorick, P.V. (author), TNO Kwaliteit van Leven (author) article 2007
- document
- Sanders, M.M. (author), Visser, J.H.M. (author) article 2007
- document
-
van Erp, J.B.F. (author), van Veen, H.A.H.C. (author), Ruijsendael, M. (author), TNO Defensie en Veiligheid (author)Data show that spatial orientation in microgravity differs from that on Earth possibly facilitating space motion sickness and degrading performance. As a technology demonstration, we developed a Tactile Orientation Awareness Support Tool (TOAST) consisting of a vest with 56 vibrators. TOAST presents an artificial gravity vector by a localised...article 2007
- document
-
Koster, S. (author), Verpoorte, E. (author), TNO Kwaliteit van Leven (author)This review presents a thorough overview covering the period 1997-2006 of microfluidic chips coupled to mass spectrometry through an electrospray interface. The different types of fabrication processes and materials used to fabricate these chips throughout this period are discussed. Three 'eras' of interfaces are clearly distinguished. The...article 2007
- document
- Bles, W. (author), Wentink, M. (author), Mayrhofer, M. (author), de Graaf, B. (author), TNO Defensie en Veiligheid (author) article 2007