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Parnham, M.J. (author), Bogaards, J.J.P. (author), Schrander, F. (author), Schut, M.W. (author), Orešković, K. (author), Mildner, B. (author), TNO Kwaliteit van Leven (author)PLD-118 is a novel, oral antifungal drug, under development for the treatment of Candida infections. Possible metabolism of PLD-118 by rat, dog and human S9 liver homogenates and inhibition of human cytochrome P450 (CYP) enzymes were investigated. PLD-118 (10 and 100 μm) incubated for 0-60 min with S9 fractions and NADPH was determined by HPLC,...article 2005
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van Dijk, F.J.H. (author), Kwantes, J.H. (author), TNO Kwaliteit van Leven (author)Beroepsziekten en gezondheidsrisico's moeten worden aangepakt in bedrijven. Werkgevers en werknemers zijn daarom verplicht samen vorm te geven aan een preventief beleid in het bedrijf. Ze worden daarbij geadviseerd door bedrijfsartsen en andere arbospecialisten, vaak werkend in een arbodienst. De voorwaarden voor een gezond beleid in een bedrijf...bookPart 2005
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Lee, J.J. (author), Livingston, S. (author), Koenig, R. (author), Nagata, D. (author), Lai, L. (author), Neto, A. (author), TNO Defensie en Veiligheid (author)A wideband long slot array was recently developed for radar and EW applications. Theoretically the new design has unlimited bandwidth if no ground plane is included but at the expense of 3 dB loss in gain because of bi-directional radiation. In practice, however, a ground plane is used which limits the bandwidth to about 5:1. Ground plane...conference paper 2005
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Portengen, L. (author), Preller, L. (author), Tielen, M. (author), Doekes, G. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author)Background: Recent studies have reported a low prevalence of atopic sensitization and respiratory allergy in children growing up on farms. Objectives: We sought to evaluate the dose-response relationship between endotoxin and atopic sensitization in adult farmers and to assess the effect on respiratory health outcomes. Methods: Data on endotoxin...article 2005
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- Vos, J.J. (author), TNO Defensie en Veiligheid (author) article 2005
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Elferink, H. (author), Eijk, A. (author), TNO Industrie en Techniek (author)During the lifetime of an existing gas well, located in the D15FA/FB field in the North Sea, the pressure has dropped and consequently production is reduced. A depletion compressor must be added therefore to this existing platform to increase the production. This sounds easy but has been very challenging due to physical and other restrictions....conference paper 2005
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Donkervoort, D.R. (author), de Kroon, J.C.A. (author), Geurts, C.P.W. (author), TNO Bouw en Ondergrond (author)Vernieuwingen in de bouw hebben traditioneel in hoofdzaak plaats binnen het invloedsgebied van de afzonderlijke partijen: ontwerpers, bouwbedrijven, toeleverende industrie, enz. Om een doorbraak te realiseren is een integrale aanpak noodzakelijk van zowel het bouwproces als de bijbehorende producten. Deze doorbraak zal leiden tot een...article 2005
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- Nijland, T.G. (author), van der Zon, W.H. (author), Pachen, H.M.A. (author), van Hille, T. (author), TNO Bouw en Ondergrond (author) article 2005
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Hoeksma, M. (author), van Rijn, M. (author), Verkerk, P.H. (author), Bosch, A.M. (author), Mulder, M.F. (author), de Klerk, J.B.C. (author), de Koning, T.J. (author), Rubio-Gozalbo, E. (author), de Vries, M. (author), Sauer, P.J.J. (author), van Spronsen, F.J. (author), TNO Preventie en Gezondheid (author)In a previous study, Dutch children with phenylketonuria (PKU) were found to be slightly shorter than their healthy counterparts. In the literature, it has been hypothesized that a higher protein intake is necessary to optimize growth in PKU patients. The study aimed to investigate whether protein intake (total, natural and protein substitute)...article 2005
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Reijneveld, S.A. (author), Harland, P. (author), Brugman, E. (author), Verhulst, F.C. (author), Verloove-Vanhorick, S.P. (author)Background This study aims to examine a) the prevalence of psychosocial problems and b) the association between parent-reported problems and the identification by doctors and nurses (child health professionals, CHP) working in preventive child health care, among immigrant and non-immigrant children. Methods CHPs examined 4,098 children aged 5...article 2005
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Kudryashova, E.V. (author), Visser, A.J.W.G. (author), de Jongh, H.H.J. (author), TNO Kwaliteit van Leven (author)In this study the relation between the ability of protein self-association and the surface properties at air-water interfaces is investigated using a combination of spectroscopic techniques. Three forms of chicken egg ovalbumin were obtained with different self-associating behavior: native ovalbumin, heat-treated ovalbumin-being a cluster of 12...article 2005
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Geurts, C.P.W. (author), TNO Bouw en Ondergrond (author)TNO en Stichting de Metselfabriek hebben een nieuw bouwproces ontwikkeld: steigerloos bouwen met geprefabriceerde, gevelsluitende baksteen buitenspouwbladen. Inmiddels wordt in Lith een proef gedaan met de bouw van drie woningenarticle 2005
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de Theije, P.A.M. (author), van Moll, C.A.M. (author), TNO Defensie en Veiligheid (author)This paper presents an algorithm that can be used to fuse two sets of contacts, e.g. as observed by two active sonar systems. The goal is to keep a good probability of detection, without doubling the number of false alarms after combining both data sets. We present both the theoretical motivation of the algorithm, as well as simulations that...conference paper 2005
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Bakker, R.T. (author), Hogema, J.A. (author), Huiskamp, W. (author), Papp, Z. (author), TNO Defensie en Veiligheid (author)Simulation, or rather virtual testing, is a good instrument for study and design of traffic management concepts, traffic safety, vehicle safety and ergonomics. Simulation facilitates the evaluation of the design at an early stage and reduces the costs of making prototypes. The Dutch research organization TNO, recently started a new initiative...conference paper 2005
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- de Vries, S.I. (author), TNO Kwaliteit van Leven (author) bookPart 2005
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van den Heuvel, E.G.H.M. (author), Wils, D. (author), Pasman, W.J. (author), Saniez, M.H. (author), Kardinaal, A.F.M. (author), TNO Kwaliteit van Leven (author)Background: It is well documented that fermentation of carbohydrates that escape digestion exert several effects supposed to be beneficial for (colonic) health, including an increase in stool volume, a shorter intestinal transit time, production of short chain fatty acids and a decrease of colonic pH (Kritchevsky 1988). NUTRIOSE®FB is a dextrin...article 2005
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- Steeneken, P. (author), Woortman, A. (author), Jurgens, A. (author), Vernooij, W. (author), Binnema, D. (author), Oudhuis, L. (author), TNO Kwaliteit van Leven (author) article 2005
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de Jong, A.R. (author), Boumans, H. (author), Slaghek, T. (author), van Veen, J. (author), Rijk, R. (author), van Zandvoort, M.M.J. (author), TNO Kwaliteit van Leven (author)This paper gives an overview of the legal consequences of a new EU framework regulation on food contact materials which includes controls on active and intelligent packaging. Recent developments in active and intelligent packaging systems are described, two examples of which aim at achieving improvements in quality and safety of food products....article 2005
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- Ainslie, M.A. (author), Morfey, C.L. (author), TNO Defensie en Veiligheid (author) article 2005
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van Velzen-Mol, H.W.M. (author), TNO Kwaliteit van Leven (author)De standaard ‘Opsporing visuele stoornissen 0-19 jaar’ is de tweede in een reeks standaarden die door en voor de jgz wordt gemaakt. De eerste standaard ‘Vroegtijdige opsporing gehoorstoornissen 0-19 jaar’ is in 1998 verschenen. Daarna heeft het ministerie van vws toegezegd om ten minste twintig standaarden jgz te financieren. Begeleiding vanuit...book 2005