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Martens, M.H. (author)Road scene analyses are a very useful tool for assessing the causes of unsafe traffic situations in a relatively easy manner. Three examples are provided to illustrate this principle.bookPart 2000
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Brama, P.A.J. (author), Tekoppele, J.M. (author), Bank, R.A. (author), Karssenberg, D. (author), Barneveld, A. (author), van Weeren, P.R. (author)The aim of this study was to evaluate topographical differences in the biochemical composition of the extracellular matrix of articular cartilage of the normal equine fetlock joint. Water content, DNA content, glycosaminoglycan (GAG) content and a number of characteristics of the collagen network (total collagen content, levels of hydroxylysine-...article 2000
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de Jonge, J. (author), Dollard, M.F. (author), Dormann, C. (author), Le Blanc, P.M. (author), Houtman, I.L.D. (author)The purpose of this study was to test the Demand-Control Model (DCM), accompanied by three goals. Firstly, we used alternative, more focused, and multifaceted measures of both job demands and job control that are relevant and applicable to today's working contexts. Secondly, this study intended to focus on particular demands in human services...article 2000
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Mayer, P. (author), Vaes, W.H.J. (author), Hermens, J.L.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The use of solid-phase microextraction with poly(dimethylsiloxane) (PDMS)-coated glass fibers for the extraction and analysis of hydrophobic organic analytes is increasing. The literature on this topic is characterized by large discrepancies in partition coefficients and an uncertainty of whether highly hydrophobic analytes are retained by...article 2000
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Noort, D. (author), Hulst, A.G. (author), Fidder, A. (author), van Gurp, R.A. (author), de Jong, L.P.A. (author), Benschop, H.P. (author), Prins Maurits Laboratorium TNO (author)The development of procedures for retrospective detection and quantitation of exposure to phosgene, based on adducts to hemoglobin and albumin, is described. Upon incubation of human blood with [14C]phosgene (0-750 μM), a significant part of radioactivity (0-13%) became associated with globin and albumin. Upon Pronase digestion of globin, one of...article 2000
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Barth, P.G. (author), Hirasing, R.A. (author), TNO Preventie en Gezondheid (author)The prevalence of the severe disease spina bifida is decreasing, but the present rate is still unacceptably high. Only one-third of women planning motherhood use the recommended folic acid, although compliance is increasing. Campaigns for the use of folic acid by these women should be intensified. This method, however, cannot completely prevent...article 2000
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- Jetten, J. (author), van Veen, S. (author) article 2000
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de Leeuw, G. (author), Neele, F.P. (author), Hill, M.K. (author), Smith, M.H. (author), Vignati, E. (author), TNO Fysisch en Elektronisch Laboratorium (author)quantitative source function for sea spray aerosol produced by waves breaking in the surf zone was determined from data collected with optical particle counters at both sides of the surf zone at two locations on the Californian coast. Three optical particle counters were used to measure profiles at the base of a pier; a fourth instrument was...article 2000
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- van der Gaag, M.S. (author), Sierksma, A. (author), Schaafsma, G. (author), van Tol, A. (author), Geelhoed-Mieras, T. (author), Bakker, M. (author), Hendriks, H.F.J. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author) article 2000
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Izeboud, C.A. (author), Vermeulen, R.M. (author), Zwart, A. (author), Vos, H.P. (author), van Miert, A.S.J.P.A.M. (author), Witkamp, R.F. (author)Previous research has shown that β-adrenoceptor (β-AR) agonists have potent anti-inflammatory capabilities, e.g. represented by suppression of release of the proinflammatory cytokines. Aim of this research was to determine whether the effects of β-agonists on LPS-induced TNFα and IL-10 release are influenced by their different stereochemistry....article 2000
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- de Jong, R.G. (author), Vos, H. (author), TNO Preventie en Gezondheid (author) report 2000
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Ordentlich, A. (author), Barak, D. (author), Kronman, C. (author), Benschop, H.P. (author), de Jong, L.P.A. (author), Ariel, N. (author), Barak, R. (author), Segall, Y. (author), Velan, B. (author), Shafferman, A. (author)Structural architecture of the human acetylcholinesterase (HuAChE) active center and the effect of adduct configurations on the aging process were explored through phosphylation and aging reaction of the AchE wild type and selected mutants using the four stereoisomers of 1,2,2-trimethylpropyl methylphosphonofluoridate (soman). Reactivity of wild...conference paper 2000
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Maas, W.J.M. (author), Leeman, W.R. (author), Groten, J.P. (author), van de Sandt, J.J.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Precision-cut liver slices are frequently used to study hepatic toxicity and metabolism of xenobiotics in vitro. Successful cryopreservation techniques will enhance an efficient and economic use of scarcely available (human) liver tissue. For primary hepatocytes, slow freezing has been accepted as the best approach towards successful...article 2000
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Schuurman, A.G. (author), Goldbohm, R.A. (author), Dorant, E. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)In the Netherlands Cohort Study, the authors investigated whether anthropometry is associated with prostate cancer risk. At baseline in 1986, 58,279 men aged 55-69 years completed a self- administered questionnaire on diet, anthropometry, and other risk factors for cancer. After 6.3 years of follow-up, 681 cases were available with complete data...article 2000
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Robinson, L. (author), McIlwaine, I. (author), Copestake, P. (author), Anderson, C. (author), TNO BIBRA TNO Kwaliteit van Leven (author)An evaluation of toxicology information resources is reported, comparing commercial online databases specialized in-house database. A mixed qualitative/quantitative approach, using 10 test queries and detailed failure analysis was used. The main conclusions are: the in-house database is superior to any `general' database in recall and precision;...article 2000
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Keizer, W.P.M.N. (author), TNO Fysisch en Elektronisch Laboratorium (author)This paper gives an overview of the activities of Working Group 2 in COST Action 260. The COST 260 Action started in 1997 and will continue till the end of the year 2001. The presented information is largely retrieved from papers presented at two COST 260 Workshops organised in Dec.'97 and Nov. '99, and three other COST 260 Working Group...conference paper 2000
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Koning, R.F.F. (author), Chou, C.T. (author), Verhaegen, M.H.G. (author), Klaassens, J.B. (author), Uittenbogaart, J.R. (author)AC machines are applied in actuator systems for many applications. The development of fast processors open up the possibilities to apply new techniques for identification and control of electrical drives in real-time, so as to improve and optimize their performances. The paper presents a systematic approach to identify the physically relevant...article 2000
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de Looze, M.P. (author), Steenhuizen, S. (author), Boeken-Kruger, M.C. (author), Baten, C.T.M. (author), Kingma, I. (author), van Dieën, J.H. (author)People who know the actual mass of an object to be lifted normally prepare themselves before attempting a lift to control the movement and to minimize low back loading. In this study, the trunk muscular reactions and low back torque were investigated in the situation in which the individual did not know the actual mass but only had some idea of...article 2000
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van der Werf, M.J. (author), Boot, A.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Rhodococcus euythropolis DCL14 assimilates all stereoisomers of carveol and dihydrocarveol as sole source of carbon and energy. Induction experiments with carveol- or dihydrocarveol-grown cells showed high oxygen consumption rates with these two compounds and with carvone and dihydrocarvone. (Dihydro)carveol-grown cells of R. erythropolis DCL14...article 2000
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- Steeneken, H.J.M. (author) bookPart 2000