Heterogeneity of pituitary follicula-stellate cells: Implications for iterleukin-6 production and accessory function in vitro

The population of folliculo-stellate (FS) cells of the rat anterior pituitary has been shown to be ultrastructurally and immunohistochemically heterogeneous. Based on the overlap of ultrastructural characteristics, the localization in the anterior pituitary and the co-expression within the same cel of the S-100 protein (a marker for FS cells)...

Determination of average glandular dose with modern mammography units for two large groups of patients

Until recently, for mammography Mo anode-Mo filter x-ray tube assemblies were almost exclusively used. Modern mammography units provide the possibility to employ a variety of anode-filter combinations with the aim of adapting the x-ray spectrum to compressed breast thickness and composition. The present contribution provides information on the...

Biologische risico's in de gezondheidszorg en in laboratoria

Deze 'Praktijkgids Arbeidshygiëne' gaat over het beheersen van biologische risico's in de gezondheidszorg en in laboratoria. Er wordt ingegaan op het ontstaan van biologische risico's en de biologische factoren die daarbij een rol spelen. Vervolgens wordt bekeken welke bedreiging de biologische risico's voor de gezondheid vormen en welke...

Monoclonal gammopathies in aging μ,χ-transgenic mice: Involvement of the B-1 cell lineage

Monoclonal gammopathies (MG) are monoclonal proliferative disorders of B cells at the differentiation stage of Ig production. They can be detected in the serum, either as transient or as persistent homogenous immunoglobulin (H-Ig) components. The exact phenotype, localization, and cell lineage origin of the precursor cells of MG are unknown, but...

Fitting ARMA time series by structural equation models

This paper outlines how the stationary ARMA(p, q) model can be specified as a structural equations model. Maximum likelihood estimates for the parameters in the ARMA model can be obtained by software for fitting structural equation models. For pure AR and mixed ARMA models, these estimates are approximately unbiased, while the efficiency is as...

The IPCS collaborative study on neurobehavioral screening models

The International Programme on Chemical Safety sponsored a collaborative study to evaluate the utility of neurobehavioral test methods for identifying neurotoxic chemicals. The protocol consisted of a functional observational battery and automated assessment of motor activity. The study involved four laboratories in the United States and four in...

IV. Molecular biology of S-layers

In this chapter we report on the molecular biology of crystalline surface layers of different bacterial groups. The limited information indicates that there are many variations on a common theme. Sequence variety, antigenic diversity, gene expression, rearrangements, influence of environmental factors and applied aspects are addressed. There is...

Relationship between the parameters cellular differentiation, doubling time and platinum accumulation and cisplatin sensitivity in a panel of head and neck cancer cell lines

Patients with head and neck squamous cell carcinoma (HNSCC) treated with cisplatin show a large inter-individual variation in tumor response. Little is known about factors that contribute to this variation. The aim of our study was to correlate the sensitivity to cisplatin with a number of cellular parameters using a panel of 10 human HNSCC cell...

Energy and fat compensation during long term consumption of reduced fat products

The objective of this study was to investigate the behavioral response to the long term realistic consumption of reduced fat products. During six months, a control group of 103 subjects had free access to about 45 commercially available full-fat products, and a reduced-fat group of 117 subjects had access to the reduced fat equivalents. These...

Disruption of sexual differentiation in genetic male common carp (Cyprinus carpio) exposed to an alkylphenol during different life stages

A genetically male population of the common carp, Cyprinus carpio, was exposed to a measured concentration of 0.14 mg/L 4-tert-pentylphenol (TPP) for various periods before and during sexual differentiation in order to determine the presence of a labile period for endocrine disruption. Exposure to TPP for 3 days during the embryo-larval period...

Rapid target analysis of microcontaminants in water by on-line single-short-column liquid chromatography combined with atmospheric pressure chemical ionization tandem mass spectrometry

The applicability of trace enrichment and separation of microcontaminants on a 10 mmx2 mm I.D. high-pressure packed (8 μm C18 bonded silica or 10-15 μm PLRP-S) column combined on-line with an atmospheric pressure chemical ionization MS-MS system is demonstrated for the target analysis of herbicides in river water. Tailor-made procedures are...

Reduced bone mass in dutch adolescents fed a macrobiotic diet in early life

This study investigated the effect of a macrobiotic (vegan-type) diet, low in calcium and vitamin D, consumed in early life, on bone mineral during adolescence. Bone mineral content (BMC) and bone area were measured in 195 adolescents (103 girls, 92 boys) aged 9-15 years, using dual-energy X-ray absorptiometry. Ninety-three adolescents (43 girls...

Influence of different types of protein on in vitro availability of intrinsic and extrinsic iron and zinc

The influence of beef, pork and soy proteins on intrinsic and extrinsic iron and zinc in vitro availability was investigated, by measuring mineral dialysability. Intrinsic iron dialysability (percentage of iron dialysed) was similar in the animal proteins and higher than that from soy protein isolate (P < 0.001). Intrinsic zinc dialysability...

Van collectieve verdediging naar collectieve veiligheid? De aanpassing en uitbreiding van de NAVO

Verloren onschuld: De rol van Nederland bij VN-operaties

25 Jaar kwetsbaarheids- en letaliteitsonderzoek bij TNO-PML

Vijftig jaar TNO-Defensieonderzoek bij TNO-PML - Editoriaal