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Huisman, L.G.M. (author), Meijer, P. (author), van Griensven, J. (author), Kluft, C. (author), Gaubius Laboratory Instituut voor verouderings- en vaatziekten onderzoek TNO (author)t-PA depleted citrated plasma was used to prepare standards of different molecular forms of plasminogen activator inhibitor 1 (PAI-1). These standards were used to evaluate the specificity of two new PAI-1 antigen assays: the TintElize PAI-1 antigen assay (cat. no. 210221) and the Innotest PAI-1. Differences in specificity were apparent: the...article 1992
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- Stelwagen, U. (author), Technisch Physische Dienst TNO - TH (author) article 1992
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Grøn, B. (author), Filion-Myklebust, C. (author), Benninck, A. (author), Nieuwenhuizen, W. (author), Matsueda, G.R. (author), Brosstad, F. (author), Gaubius instituut Instituut voor verouderings- en vaatziekten onderzoek TNO (author)alpha-polymer formation, as opposed to gamma-chain dimerization has been considered a relatively late event in factor XIII-induced fibrin stabilization. Recently it has been shown, however, that plasma from healthy individuals and from patients with fibrinaemia contains small amounts of soluble fibrin/fibrinogen oligomers interlinked through...article 1992
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Ens-Dokkum, M.H. (author), Schreuder, A.M. (author), Veen, S. (author), Verloove-Vanhorick, S.P. (author), Brand, R. (author), Ruys, J.H. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)Since the introduction of neonatal intensive care in the 1960s, mortality in very preterm and very low birthweight infants has been decreasing steadily. Consequently, interest in the outcome of surviving infants is growing. Restriction of health care resources has stressed the need for information concerning the effect of individual treatment...article 1992
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- Wesseling, K.H. (author), Technisch Physische Dienst TNO - TH (author) article 1992
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Haan, J. (author), Kluft, C. (author), Leebeek, F.W.G. (author), de Bart, A.C.W. (author), Buruma, O.J. (author), Roos, R.A.C. (author)In view of reported associations between increased bleeding tendency and systemically decreased alpha 2-antiplasmin in patients with systemic amyloid deposition we studied alpha 2-antiplasmin, fibrinogen, C-reactive protein and blood levels of locally produced endothelial hemostasis factors in the acute and quiescent phase in 16 patients with...article 1992
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Zwart, A. (author), Arts, J.H.E. (author), ten Berge, W.F. (author), Appelman, L.M. (author)A new design for acute inhalation toxicity testing was evaluated and compared with results obtained according to OECD guideline 403. The new design consists of a range-finding test, which is compatible with a conventional limit test, and can be followed by determination of a concentration-time-mortality relationship, enabling calculation of LC50...article 1992
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- Bos, W.J.W. (author), Technisch Physische Dienst TNO - TH (author) article 1992
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Happee, R. (author), TNO Wegtransportmiddelen (author)The use of computer simulation techniques in automotive crash safety design has rapidly increased in the past years. For the human body as well as the restraint systems, e.g. seat belts and airbags, computer models are becoming more and more realistic. In existing Crash Victim Simulation programs the occupant is represented by a system of rigid...article 1992
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de Geus, E.J.C. (author), Kluft, C. (author), de Bart, A.C. (author), van Doornen, L.J. (author), Gaubius instituut Instituut voor verouderings- en vaatziekten onderzoek TNO (author)Plasminogen activator inhibitor (PAI) activity, an important regulator within the fibrinolytic system, has been shown to be a risk indicator for venous and arterial thrombosis. The present study aimed to test the effects of exercise training on PAI activity, and to link possible changes in PAI activity to changes in cardiovascular fitness, body...article 1992
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Haverkate, F. (author), Gaubius Instituut TNO (author)Acute-phase markers such as erythrocyte sedimentation rate, leucocyte count and plasma levels of fibrinogen and C-reactive protein are increased in individuals at risk of a cardiac event. This was established in several large prospective studies. Increased plasminogen activator inhibitor (PAI-1) and tissue-plasminogen activator (t-PA) antigen in...article 1992
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- Ockhuizen, T. (author), Instituut voor Toxicologie en Voeding TNO (author) article 1992
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Kunz, G.J. (author), Lamberts, C.W. (author), van Mierlo, G.W.M. (author), de Vries, F.P.P. (author), Visser, H. (author), Smorenburg, C. (author), Spitzer, D. (author), Hofstraat, H. (author), Dirks, R.W.J. (author), Fysisch en Elektronisch Laboratorium TNO Technisch Physische Dienst TNO - TH (author)Four institutes were involved in a common program to study the potentials of an airborne laser bathymetry system. Apart from the determination of the water depth, a laser bathymetry system can also be applied for measuring the scattering properties of the water and for obtaining information on the water surface. The optical path from the sensor...article 1992
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Drykoningen, C.E.M. (author), Mulder, A.L.M. (author), Vaandrager, G.J. (author), LaPorte, R.E. (author), Bruining, G.J. (author), Nederlands instituut voor praeventieve gezondheidszorg TNO TNO Preventie en Gezondheid (author)This study evaluates the cumulative incidence of Type 1 (insulin-dependent) diabetes mellitus in male army conscripts 0-18 (inclusive) years of age in the Netherlands (birth cohorts) over 10 years. Data from 2136 cases were retrieved from files of the conscript registry of the Royal Dutch Army. Ascertainment was sought by the capture-recapture...article 1992
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- Defize, P. (author), Technisch Physische Dienst TNO - TH (author) article 1992
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Emeis, J.J. (author), van den Hoogen, C.M. (author), Gaubius Laboratory IVVO-TNO, P.O. Box 430, 2300 AK Leiden, Netherlands Instituut voor verouderings- en vaatziekten onderzoek TNO (author)Pharmacological modulation of the in vivo induction of plasminogen activator inhibitor type-1 (PAI-1) synthesis was studied in rats using the induction of PAI-1 by endotoxin as a model system. Both the cyclooxygenase inhibitors acetylsalicylic acid and indomethacin enhanced PAI-1 induction. The combined cyclooxygenase-lipoxygenase inhibitor,...article 1992
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- Beerkens, R.G.C. (author), Muysenberg, H.P.H. (author), Technisch Physische Dienst TNO - TH (author) article 1992
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- Potter van Loon, B.J. (author), IVVO-TNO (author) article 1992
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van den Dool, T.C. (author), Technisch Physische Dienst TNO - TH (author)Unwanted sound can be cancelled by adding to it sound of identical strength and opposite phase. This type of sound reduction is also called Anti-Noise or Active Noise Control and was patented by the German physicist Paul Lueg back in 1933. Although some researchers tried to make anti-noise systems work in practice, results were poor due to lack...article 1992
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- Kuper, C.F. (author), Koornstra, P.J. (author), Hameleers, D.M.H. (author), Biewenga, J. (author), Spit, B.J. (author), Duijvestijn, A.M. (author), van Breda Vriesman, P.J.C. (author), Sminia, T. (author), Centraal Instituut voor Voedingsonderzoek TNO (author) article 1992