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Galeotti, F. (author), Lindgren, G. (author), Petruzzella, M. (author), van Otten, F.W.M. (author), Sadeghian Marnani, H. (author), Mohtashami, A. (author), van der Heijden, R. (author), Fiore, A. (author)The low throughput of atomic force microscopy (AFM) is the main drawback in its large-scale deployment in industrial metrology. A promising solution would be based on the parallelization of the scanning probe system, allowing acquisition of the image by an array of probes operating simultaneously. A key step for reaching this goal relies on the...article 2021
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Galeotti, F. (author), Sersic-Vollenbroek, I. (author), Petruzzella, M. (author), Pagliano, F. (author), Zobenica, Z. (author), van Otten, F.W.M. (author), Sadeghian Marnani, H. (author), van der Heijden, R. (author), Fiore, A. (author)Displacement sensing at the nanoscale is required in many applications, including accelerometry, mass sensing and atomic force microscopy. Miniaturization of the sensing elements and integration of the read-out is key in achieving low cost, high resolution and high speed. Here, we present a novel integrated nano-opto-electro-mechanical device...conference paper 2018
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Morrison, M. (author), van der Heijden, R. (author), Heeringa, P. (author), Kaijzel, E. (author), Verschuren, L. (author), Blomhoff, R. (author), Kooistra, T. (author), Kleemann, R. (author)Objective: Previous studies investigating flavanol-rich foods provide indications for potential cardioprotective effects of these foods, but the effects of individual flavanols remain unclear. We investigated whether the flavanol epicatechin can reduce diet-induced atherosclerosis, with particular emphasis on the cardiovascular risk factors...article 2014
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van der Kloet, F.M. (author), Tempels, F.W.A. (author), Ismail, N. (author), van der Heijden, R. (author), Kasper, P.T. (author), Rojas-Cherto, M. (author), van Doorn, R. (author), Spijksma, G. (author), Koek, M. (author), van der Greef, J. (author), Mäkinen, V.P. (author), Forsblom, C. (author), Holthöfer, H. (author), Groop, P.H. (author), Reijmers, T.H. (author), Hankemeier, T. (author)Diabetic kidney disease (DKD) is a devastating complication that affects an estimated third of patients with type 1 diabetes mellitus (DM). There is no cure once the disease is diagnosed, but early treatment at a sub-clinical stage can prevent or at least halt the progression. DKD is clinically diagnosed as abnormally high urinary albumin...article 2012
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Yakala, G.K. (author), van der Heijden, R. (author), Molema, G. (author), Schipper, M. (author), Wielinga, P.Y. (author), Kleemann, R. (author), Kooistra, T. (author), Heeringa, P. (author)Background: An Alternating high- cholesterol dietary regimen has proven to be beneficial when compared to daily high- cholesterol feeding. In the current study we explored whether the same strategy is applicable to a high- fat dietary regimen. Objective: To investigate whether an alternating high- fat dietary regimen can effectively diminish...article 2012
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Hu, C. (author), Wei, H. (author), Kong, H. (author), Bouwman, J. (author), Gonzalez-Covarrubias, V. (author), van der Heijden, R. (author), Reijmers, T.H. (author), Bao, X. (author), Verheij, E.R. (author), Hankemeier, T. (author), Xu, G. (author), van der Greef, J. (author), Wang, M. (author)Although a number of animal experiments and clinical trials have investigated the effects of ginseng roots on diabetes, the relationship between their therapeutic effects on diabetes and the quality and the growth age of this herb have not yet been reported. This study systematically investigated the effects of 3- to 6-year-old ginseng roots on...article 2011
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Chang, W.T. (author), Choi, Y.H. (author), van der Heijden, R. (author), Lee, M.S. (author), Lin, M.K. (author), Kong, H. (author), Kim, H.K. (author), Verpoorte, R. (author), Hankemeier, T. (author), van der Greef, J. (author), Wang, M. (author)The processing of biological raw materials is considered to have an important role in the therapeutic application in Traditional Chinese Medicine. The root of Rehmannia glutinosa has to be processed by nine cycles of rice wine immersing, steaming and drying before using in clinical applications. In order to understand the chemical changes...article 2011
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Hu, C. (author), Wei, H. (author), van den Hoek, A.M. (author), Wang, M. (author), van der Heijden, R. (author), Spijksma, G. (author), Reijmers, T.H. (author), Bouwman, J. (author), Wopereis, S. (author), Havekes, L.M. (author), Verheij, E. (author), Hankemeier, T. (author), Xu, G. (author), van der Greef, J. (author)Background: Lipids are known to play crucial roles in the development of life-style related risk factors such as obesity, dyslipoproteinemia, hypertension and diabetes. The first selective cannabinoid-1 receptor blocker rimonabant, an anorectic anti-obesity drug, was frequently used in conjunction with diet and exercise for patients with a body...article 2011
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Song, G.S. (author), Zhai, H.L. (author), Peng, Y.G. (author), Zhang, L. (author), Wei, G. (author), Chen, X.Y. (author), Xiao, Y.G. (author), Wang, L. (author), Chen, Y.J. (author), Wu, B. (author), Chen, B. (author), Zhang, Y. (author), Chen, H. (author), Feng, X.J. (author), Gong, W.K. (author), Liu, Y. (author), Yin, Z.J. (author), Wang, F. (author), Liu, G.Z. (author), Xu, H.L. (author), Wei, X.L. (author), Zhao, X.L. (author), Ouwerkerk, P.B.F. (author), Hankemeier, T. (author), Reijmers, T. (author), van der Heijden, R. (author), Lu, C.M. (author), Wang, M. (author), van der Greef, J. (author), Zhu, Z. (author), TNO Kwaliteit van Leven (author)Heterosis is a biological phenomenon whereby the offspring from two parents show improved and superior performance than either inbred parental lines. Hybrid rice is one of the most successful apotheoses in crops utilizing heterosis. Transcriptional profiling of F1 super-hybrid rice Liangyou-2186 and its parents by serial analysis of gene...article 2010
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Kamphorst, J.J. (author), Tjaden, U.R. (author), van der Heijden, R. (author), de Groot, J. (author), van der Greef, J. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)Considerable interest exists in endogenous peptides as potential biomarkers, since they act as signaling molecules and are formed by degradation of proteins. A crucial step in the profiling of these peptides is the sample preparation, which aims to enrich the low-abundant peptides, while removing interfering matrix compounds. In a feasibility...article 2009
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Hu, C. (author), van der Heijden, R. (author), Wang, M. (author), van der Greef, J. (author), Hankemeier, T. (author), Xu, G. (author), TNO Kwaliteit van Leven (author)Lipidomics is a lipid-targeted metabolomics approach aiming at comprehensive analysis of lipids in biological systems. Recently, lipid profiling, or so-called lipidomics research, has captured increased attention due to the well-recognized roles of lipids in numerous human diseases to which lipid-associated disorders contribute, such as diabetes...article 2009
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Wang, J. (author), Reijmers, T. (author), Chen, L. (author), van der Heijden, R. (author), Wang, M. (author), Peng, S. (author), Hankemeier, T. (author), Xu, G. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)A metabolomics-based systems toxicology approach was used to profile the urinary metabolites for the toxicity related processes and pathogenesis induced by doxorubicin (DOX) to rats. Endogenous metabolite profiles were obtained with ultra performance liquid chromatography-mass spectrometry (UPLC-MS) for rats receiving different single dosages of...article 2009
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Kong, H. (author), Wang, M. (author), Venema, K. (author), Maathuis, A. (author), van der Heijden, R. (author), van der Greef, J. (author), Xu, G. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)A high-performance liquid chromatography-high resolution Fourier transform ion cyclotron resonance mass spectrometry (HPLC-FTICR-MS) method was developed to investigate the metabolism of ginsenosides in in vitro models of the gastro-intestinal tract. The metabolites were identified by high-resolution tandem mass spectrometry. Degradation and...article 2009
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Wang, J. (author), van der Heijden, R. (author), Spruit, S. (author), Hankermeier, T. (author), Chan, K. (author), van der Greef, J. (author), Xu, G. (author), Wang, M. (author), TNO Kwaliteit van Leven (author)Chinese herbal medicines, often referred as Chinese materia medica (CMM), are comprised of a complex multicomponent nature. The activities are aimed at the system level via interactions with a multitude of targets in the human body. This review aims at the toxicity aspects of CMM and its preparations at the different steps of production;...article 2009
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Wang, J. (author), van der Heijden, R. (author), Spijksma, G. (author), Reijmers, T. (author), Wang, M. (author), Xu, G. (author), Hankemeier, T. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)A matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) method was developed for the high throughput and robust qualitative profiling of alkaloids in Fuzi-the processed lateral roots of the Chinese herbal medicine Aconitum carmichaeli Debx (A. carmichaeli). After optimization, powdered roots - without any further sample...article 2009
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- Hu, C. (author), van Dommelen, J. (author), van der Heijden, R. (author), Spijksma, G. (author), Reijmers, T.H. (author), Wang, M. (author), Slee, E. (author), Lu, X. (author), Xu, G. (author), van der Greef, J. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author) article 2008
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Hu, C. (author), van Dommelen, J. (author), van der Heijden, R. (author), Spijksma, G. (author), Reijmers, T.H. (author), Wang, M. (author), Slee, E. (author), Lu, X. (author), Xu, G. (author), van der Greef, J. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)A reversed-phase liquid chromatography-linear ion trap-Fourier transform ion cyclotron resonance-mass spectrometry method was developed for the profiling of lipids in human and mouse plasma. With the use of a fused-core C<sub>8</sub> column and a binary gradient, more than 160 lipids belonging to eight different classes were detected in a single...article 2008
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Kamphorst, J.J. (author), van der Heijden, R. (author), de Groot, J. (author), Lafeber, F.P.J.G. (author), Reijmers, T.H. (author), van El, B. (author), Tjaden, U.R. (author), van der Greef, J. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)Synovial fluid potentially contains markers for early diagnosis and disease progression in degenerative joint diseases such as osteoarthritis. Here, a method is described for profiling endogenous peptides in human synovial fluid, using ultrafiltration, solid-phase extraction, nanoscale liquid chromatography, and high-resolution mass spectrometry...article 2007
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- Benavente, F. (author), van der Heijden, R. (author), Tjaden, U.R. (author), van der Greef, J. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author) article 2006
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Wang, M. (author), Lamers, R.J.A.N. (author), Korthout, H.A.A.J. (author), van Nesselrooij, J.H.J. (author), Witkamp, R.F. (author), van der Heijden, R. (author), Voshol, P.J. (author), Havekes, L.M. (author), Verpoorte, R. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)The introduction of the concept of systems biology, enabling the study of living systems from a holistic perspective based on the profiling of a multitude of biochemical components, opens up a unique and novel opportunity to reinvestigate natural products. In the study of their bioactivity, the necessary reductionistic approach on single active...article 2005
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