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Effect of moderate alcohol consumption on plasma dehydroepiandrosterone sulfate, testosterone, and estradiol levels in middle-aged men and postmenopausal women: A diet-controlled intervention study

Sierksma, A. (author), Sarkola, T. (author), Eriksson, C.J.P. (author), van der Gaag, M.S. (author), Grobbee, D.E. (author), Hendriks, H.F.J. (author), TNO Voeding (author)

Background: Moderate alcohol consumption is inversely associated with cardiovascular diseases. Changes in hormone levels might in part help explain the positive health effect. This study was performed to examine the effect of moderate alcohol consumption on plasma dehydroepiandrosterone sulfate (DHEAS), testosterone, and estradiol levels....

article 2004

document

Effect of Moderate Alcohol Consumption on Parameters of Reverse Cholesterol Transport in Postmenopausal Women

Sierksma, A. (author), Vermunt, S.H.F. (author), Lankhuizen, I.M. (author), van der Gaag, M.S. (author), Scheek, L.M. (author), Grobbee, D.E. (author), van Tol, A. (author), Hendriks, H.F.J. (author), TNO Voeding (author)

Background: Alcohol consumption is associated with increased high-density lipoprotein (HDL) cholesterol levels. One of the main antiatherogenic functions of HDL is reverse cholesterol transport. Three early steps of reverse cholesterol transport are (1) cellular cholesterol efflux, (2) plasma cholesterol esterification (EST), and (3) cholesteryl...

article 2004

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Effect of type of alcoholic beverages on carbohydrate-deficient transferrin, sialic acid, and liver enzymes

Sillanaukee, P. (author), van der Gaag, M.S. (author), Sierksma, A. (author), Hendriks, H.F.J. (author), Strid, N. (author), Pönniö, M. (author), Nikkari, S.T. (author)

Background: There are only limited data obtained under well controlled conditions on the effects of moderate drinking on markers of alcohol use disorders. The aim of this study was to investigate the effects of moderate intake of different alcoholic beverages on these markers, including carbohydrate-deficient transferrin (CDT), sialic acid (SA),...

article 2003

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Acute and chronic effects of dinner with alcoholic beverages on nitric oxide metabolites in healthy men

Sierksma, A. (author), van der Gaag, M.S. (author), Grobbee, D.E. (author), Hendriks, H.F.J. (author)

1. The present study investigated the acute and chronic effect of dinner with alcoholic beverages on serum nitric oxide (NO) metabolites, namely nitrate and nitrite (NOx), in 11 healthy, non-smoking middle-aged men. 2. In a randomized, diet-controlled, cross-over trial, subjects consumed dinner with four glasses of red wine, beer, spirits (Dutch...

article 2003

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Moderate alcohol consumption reduces plasma C-reactive protein and fibrinogen levels: A randomized, diet-controlled intervention study

Sierksma, A. (author), van der Gaag, M.S. (author), Kluft, C. (author), Hendriks, H.F.J. (author), TNO Voeding (author)

Objective: To evaluate the effect of moderate alcohol consumption on the acute phase proteins C-reactive protein and fibrinogen. Design: Randomized, diet-controlled, cross-over study. Setting: The study was performed at TNO Nutrition and Food Research, Zeist, The Netherlands. Subjects: Ten middle-aged men and 10 postmenopausal women, all...

article 2002

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Kinetics of HDL cholesterol and paraoxonase activity in moderate alcohol consumers

Sierksma, A. (author), van der Gaag, M.S. (author), van Tol, A. (author), James, R.W. (author), Hendriks, H.F.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

Background: The inverse association between moderate drinking and coronary heart disease mortality is well established. This study was performed to investigate the kinetics of the alcohol-induced increases in apo A-1, HDL cholesterol, and paraoxonase (PON) activity, as well as to study whether the alcohol-induced increases in PON activity differ...

article 2002

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Moderate alcohol consumption stimulates early steps in reverse cholesterol transport

Vermunt, S.H.F. (author), Sierksma, A. (author), van der Gaag, M.S. (author), van Tol, A. (author), Hendriks, H.F.J. (author), TNO Voeding (author)

article 2001

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Moderate alcohol consumption stimulates early steps in reverse cholesterol transport

Vermunt, S.H.F. (author), Sierksma, A. (author), van der Gaag, M.S. (author), van Tol, A. (author), Hendriks, H.F.J. (author), TNO Voeding (author)

article 2001

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Moderate alcohol consumption reduces plasma C-reactive protein and fibrinogen levels

Sierksma, A. (author), van der Gaag, M.S. (author), Kluft, C. (author), Hendriks, H.F.J. (author), TNO Voeding (author)

article 2001

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Moderate alcohol consumption and fibrinolytic factors of pre- and postmenopausal women

Sierksma, A. (author), van der Gaag, M.S. (author), Schaafsma, G. (author), Kluft, C. (author), Bakker, M. (author), Hendriks, H.F.J. (author), TNO Voeding (author)

article 2001

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Effect of moderate alcohol consumption on fibrinogen levels in healthy volunteers is discordant with effects on C-reactive protein

Sierksma, A. (author), van der Gaag, M.S. (author), Kluft, C. (author), Hendriks, H.F.J. (author), TNO Voeding (author)

In a diet-controlled, crossover trial with 10 middle-aged men and 9 postmenopausal women, baseline concentrations of fibrinogen influenced the magnitude of decrease of fibrinogen after moderate alcohol consumption. The mechanism of reduction is specific for fibrinogen and unrelated to a reduction in C-reactive protein.

conference paper 2001

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Alcohol consumption stimulates early steps in reverse cholesterol transport

Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author), van der Gaag, M.S. (author), van Tol, A. (author), Vermunt, S.H.F. (author), Scheek, L.M. (author), Schaafsma, G. (author), Hendriks, H.F.J. (author)

Alcohol consumption is associated with increased HDL cholesterol levels, which may indicate stimulated reverse cholesterol transport. The mechanism is, however, not known. The aim of this study was to evaluate the effects of alcohol consumption on the first two steps of the reverse cholesterol pathway: cellular cholesterol efflux and plasma...

article 2001

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Moderate alcohol consumption and changes in postprandial lipoproteins of premenopausal and postmenopausal women: A diet-controlled randomized intervention study

van der Gaag, M.S. (author), Sierksma, A. (author), Schaafsma, G. (author), van Tol, A. (author), Geelhoed-Mieras, T. (author), Bakker, M. (author), Hendriks, H.F.J. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)

article 2000

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Effect of consumption of red wine, spirits and beer on serum homocysteine

van der Gaag, M.S. (author), Ubbink, J.B. (author), Sillanaukee, P. (author), Nikkari, S. (author), Hendriks, H.F.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

Serum homocysteine increases after moderate consumption of red wine and spirits, but not after moderate consumption of beer. Vitamin B6 in beer seems to prevent the alcohol-induced rise in serum homocysteine. Chemicals/CAS: Homocysteine, 454-28-4; Pyridoxine, 65-23-6

article 2000

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Moderate consumption of beer, red wine and spirits has counteracting effects on plasma antioxidants in middle-aged men

van der Gaag, M.S. (author), van den Berg, R. (author), van den Berg, H. (author), Schaafsma, G. (author), Hendriks, H.F.J. (author)

article 2000

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Alcohol: A. natuurwetenschappelijke aspecten

van der Gaag, M.S. (author), Hendriks, H.F.J. (author)

article 1999

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Report on the 7th ESBRA conference (Barcelona, Spain, 16-19 June 1999)

Sierksma, A. (author), van der Gaag, M.S. (author)

article 1999

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Daily moderate alcohol consumption increases serum paraoxonase activity; a diet-controlled, randomised intervention study in middle-aged men

van der Gaag, M.S. (author), van Tol, A. (author), Scheek, L.M. (author), James, R.W. (author), Urgert, R. (author), Schaafsma, G. (author), Hendriks, H.F.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

Moderate alcohol consumption is associated with a reduced risk of coronary heart disease. Part of this inverse association may be explained by its effects on HDL. Paraoxonase, an HDL-associated enzyme, has been suggested to protect against LDL oxidation. We examined the effects of moderate consumption of red wine, beer and spirits in comparison...

article 1999

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Daily moderate alcohol consumption increases serum paraoxonase activity: A diet-controlled, randomised intervention study in middle-aged men

van der Gaag, M.S. (author), van Tol, A. (author), Scheek, L.M. (author), James, R.W. (author), Urgert, R. (author), Schaafsma, G. (author), Hendriks, H.F.J. (author)

article 1999

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Report on the 9th ISBRA conference (Copenhagen, Denmark, 27 June - 2 July 1998)

van der Gaag, M.S. (author), Hendriks, H.F.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

article 1998