Elevated plasma fibrinogen: Cause or consequence of cardiovascular disease?

An association between increased plasma fibrinogen and an increased risk for myocardial infarction (MI) is well established, but the nature of this association is subject to debate. Our aim was to shed light on the potentially causal nature of this association. We examined whether increased plasma fibrinogen, due to a condition that is...

Seasonal variation in fibrinogen in the Rotterdam study

As evidence accumulates to implicate fibrinogen as a risk indicator for cardiovascular disease, it is of interest to study its seasonal variation. A population based cross-sectional study was performed among participants of the Rotterdam Study, a cohort of 7983 men and women, aged 55 years and over. Fibrinogen levels were measured by the...

Tissue plasminogen activator and risk of myocardial infarction: The Rotterdam study

Background: Impaired fibrinolytic capacity, as assessed by euglobulin clot lysis time or plasma concentration of fibrinolytic parameters, has been associated with an increased risk of myocardial infarction (MI). We studied the association of a polymorphism in the gene for TPA and of plasma concentrations of TPA (antigen and activity) with the...

Haemostasis and cardiovascular disease

The term 'coronary thrombosis' was derived from clinical and pathological observations on myocardial infarction made at least 80 years ago' and perhaps even earlier.'·} It was probably not until the 1930s that clinically manifest ischaemic heart disease in the form of myocardial infarction became a familiar condition rather than the unusual...

Tissue type plasminogen activator, atherosclerosis and the risk of myocardial infarction

Objective: We studied the association of plasma concentrations of tissuetype plasminogen activator (t-PA) and the, until now single documented polymorphism of the t-PA gene, with degree of atherosclerosis and the prevalence of myocardial infarction. Design: Cross-sectional, population-based case control study. Setting: A district of Rotterdam,...

Polymorphism of the blood clot lysis enzyme tissue-type plasminogen activator is associated with myocardial infarction

Objective: Impaired fibrinolysis has been suggested to be associated with increased risk of myocardial infarction. An insertion/deletion (I/D) polymorphism of the tissue-type plasminogen activator (t-PA) gene has been described which may be associated with impaired fibrinolysis. We studied the association between this polymorphism and the...

Activated protein C response and cardiovascular risk factors in the elderly - The Rotterdam Study

Background and objective. A low activated protein C (APC) response increases the risk of venous thrombosis, and possibly arterial disease. Apart from the factor V Leiden mutation, other factors may determine the level of APC response. In most studies on the association with arterial disease, cardiovascular risk factors were not appropriately...

Reduced response to activated protein C is associated with risk of stroke and transient ischaemic attack (abstract)

Objective: To investigate the association of activated protein C (APC) response and of the factor V Leiden mutation with myocardial infarction, stroke and transient ischémie attack. Design: Population-based case control study. Setting: A district of Rotterdam, the Netherlands. Participants: From the Rotterdam Study cohort that consists of 7983...

Reduced Response to Activated Protein C Is Associated with Increased Risk for Cerebrovascular Disease

Background: Resistance to activated protein C (APC), which results from various factors, including a mutation in the gene for coagulant factor V, has been associated with increased risk for venous thrombosis. However, its relation to arterial disease is still not well defined. Objective: To investigate the association of both response to APC and...

Fibrinolytic capacity and risk of myocardial infarction

Polymorphism of the blood clot lysis enzyme tissue-type plasminogen activator is associated with myocardial infarction;

Abstract