Searched for: author:"van den Berg, S.A.A."
(1 - 14 of 14)
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Geerling, J.J. (author), Boon, M.R. (author), van der Zon, G.C. (author), van den Berg, S.A.A. (author), van den Hoek, A.M. (author), Lombès, M. (author), Princen, H.M.G. (author), Havekes, L.M. (author), Rensen, P.C.N. (author), Guigas, B. (author)
Metformin is the first-line drug for the treatment of type 2 diabetes. Besides its well-characterized antihyperglycemic properties, metformin also lowers plasma VLDL triglyceride (TG). In this study, we investigated the underlying mechanisms in APOE*3-Leiden.CETP mice, a well-established model for human-like lipoprotein metabolism. We found that...
article 2014
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van den Berg, S.A.A. (author), Heemskerk, M.M. (author), Geerling, J.J. (author), van Klinken, J.B. (author), Schaap, F.G. (author), Bijland, S. (author), Berbée, J.F.P. (author), van Harmelen, V.J.A. (author), Pronk, A.C.M. (author), Schreurs, M. (author), Havekes, L.M. (author), Rensen, P.C.N. (author), van Dijk, K.W. (author)
Mutations in apolipoprotein A5 (APOA5) have been associated with hypertriglyceridemia in humans and mice. This has been attributed to a stimulating role for APOA5 in lipoprotein lipase-mediated triglyceride hydrolysis and hepatic clearance of lipoprotein remnant particles. However, because of the low APOA5 plasma abundance, we investigated an...
article 2013
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Boon, M.R. (author), van den Berg, S.A.A. (author), Wang, Y. (author), van den Bossche, J. (author), Karkampouna, S. (author), Bauwens, M. (author), de Saint-Hubert, M. (author), van der Horst, G. (author), Vukicevic, S. (author), de Winther, M.P.J. (author), Havekes, L.M. (author), Jukema, J.W. (author), Tamsma, J.T. (author), van der Pluijm, G. (author), van Dijk, K.W. (author), Rensen, P.C.N. (author)
Background/Aims:Brown adipose tissue (BAT) dissipates energy stored in triglycerides as heat via the uncoupling protein UCP-1 and is a promising target to combat hyperlipidemia and obesity. BAT is densely innervated by the sympathetic nervous system, which increases BAT differentiation and activity upon cold exposure. Recently, Bone...
article 2013
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Kühnast, S. (author), Louwe, M.C. (author), Heemskerk, M.M. (author), Pieterman, E.J. (author), van Klinken, J.B. (author), van den Berg, S.A.A. (author), Smit, J.W.A. (author), Havekes, L.M. (author), Rensen, P.C.N. (author), van der Hoorn, J.W.A. (author), Princen, H.M.G. (author), Jukema, J.W. (author)
Objective:Niacin potently lowers triglycerides, mildly decreases LDL-cholesterol, and largely increases HDL-cholesterol. Despite evidence for an atheroprotective effect of niacin from previous small clinical studies, the large outcome trials, AIM-HIGH and HPS2-THRIVE did not reveal additional beneficial effects of niacin (alone or in combination...
article 2013
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Coomans, C.P. (author), van den Berg, S.A.A. (author), Houben, T. (author), van Klinken, J.B. (author), van den Berg, R. (author), Pronk, A.C.M. (author), Havekes, L.M. (author), Romijn, J.A. (author), van Dijk, K.W. (author), Biermasz, N.R. (author), Meijer, J.H. (author)
Circadian rhythm disturbances are observed in, e.g., aging and neurodegenerative diseases and are associated with an increased incidence of obesity and diabetes. We subjected male C57Bl/6J mice to constant light [12-h light-light (LL) cycle] to examine the effects of a disturbed circadian rhythm on energy metabolism and insulin sensitivity. In...
article 2013
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van Diepen, J.A. (author), Stienstra, R. (author), Vroegrijk, I.O.C.M. (author), van den Berg, S.A.A. (author), Salvatori, D. (author), Hooiveld, G.J. (author), Kersten, S. (author), Tack, C.J. (author), Netea, M.G. (author), Smit, J.W.A. (author), Joosten, L.A.B. (author), Havekes, L.M. (author), van Dijk, K.W. (author), Rensen, P.C.N. (author)
Caspase-1 is known to activate the proinflammatory cytokines IL-1β and IL-18. Additionally, it can cleave other substrates, including proteins involved in metabolism. Recently, we showed that caspase-1 deficiency in mice strongly reduces high-fat diet-induced weight gain, at least partly caused by an increased energy production. Increased feces...
article 2013
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Coomans, C.P. (author), Geerling, J.J. (author), van den Berg, S.A.A. (author), van Diepen, H.C. (author), Garcia-Tardõn, N. (author), Thomas, A. (author), Schröder-Van Der Elst, J.P. (author), Ouwens, D.M. (author), Pijl, H. (author), Rensen, P.C.N. (author), Havekes, L.M. (author), Guigas, B. (author), Romijn, J.A. (author)
Background and Purpose Topiramate improves insulin sensitivity, in addition to its antiepileptic action. However, the underlying mechanism is unknown. Therefore, the present study was aimed at investigating the mechanism of the insulin-sensitizing effect of topiramate both in vivo and in vitro. Experimental Approach Male C57Bl/6J mice were fed a...
article 2013
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van Klinken, J.B. (author), van den Berg, S.A.A. (author), Havekes, L.M. (author), Willems Van Dijk, K. (author)
Physical activity (PA) is a main determinant of total energy expenditure (TEE) and has been suggested to play a key role in body weight regulation. However, thus far it has been challenging to determine what part of the expended energy is due to activity in freely moving subjects. We developed a computational method to estimate activity related...
article 2012
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Louwe, M.C. (author), van der Hoorn, J.W.A. (author), van den Berg, S.A.A. (author), Wouter Jukema, J. (author), Romijn, J.A. (author), van Dijk, K.W. (author), Rensen, P.C.N. (author), Smit, J.W.A. (author), Steendijk, P. (author)
Increased availability of fatty acids released from insulin-resistant adipose tissue may lead to excess fatty acid uptake in nonadipose organs, including the heart. Accumulation of toxic fatty acid intermediates may affect cardiac function. Our aim was to identify to which extent high-fat diet feeding leads to alterations in cardiac function and...
article 2012
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de Vogel-van den Bosch, J. (author), van den Berg, S.A.A. (author), Bijland, S. (author), Voshol, P.J. (author), Havekes, L.M. (author), Romijn, H.A. (author), Hoeks, J. (author), van Beurden, D. (author), Hesselink, M.K.C. (author), Schrauwen, P. (author), van Dijk, K.W. (author)
Excess dietary long-chain fatty acid (LCFA) intake results in ectopic lipid accumulation and insulin resistance. Since medium-chain fatty acids (MCFA) are preferentially oxidized over LCFA, we hypothesized that diets rich in MCFA result in a lower ectopic lipid accumulation and insulin resistance compared to diets rich in LCFA. Feeding mice high...
article 2011
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Bijland, S. (author), van den Berg, S.A.A. (author), Voshol, P.J. (author), van den Hoek, A.M. (author), Princen, H.M.G. (author), Havekes, L.M. (author), Rensen, P.C.N. (author), van Dijk, K.W. (author), TNO Kwaliteit van Leven (author)
The cholesteryl ester transfer protein (CETP) facilitates the bidirectional transfer of cholesteryl esters and triglycerides (TG) between HDL and (V)LDL. By shifting cholesterol in plasma from HDL to (V)LDL in exchange for VLDL-TG, CETP aggravates atherosclerosis in hyperlipidemic APOE*3-Leiden (E3L) mice. The aim of this study was to...
article 2010
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van den Berg, S.A.A. (author), Nabben, M. (author), Bijland, S. (author), Voshol, P.J. (author), van Klinken, J.B. (author), Havekes, L.M. (author), Romijn, J.A. (author), Hoeks, J. (author), Hesselink, M.K. (author), Schrauwen, P. (author), van Dijk, K.W. (author), TNO Kwaliteit van Leven (author)
Considerable variation in energy expenditure is observed in C57Bl/6 mice on a high-fat diet. Because muscle tissue is a major determinant of whole-body energy expenditure, we set out to determine the variation in energy expenditure and its possible association with skeletal muscle mitochondrial function upon high-fat diet intervention. Metabolic...
article 2010
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Thissen, U. (author), Wopereis, S. (author), van den Berg, S.A.A. (author), Bobeldijk, I. (author), Kleemann, R. (author), Kooistra, T. (author), van Dijk, K.W. (author), van Ommen, B. (author), Smilde, A.K. (author), TNO Kwaliteit van Leven (author)
Background: In the fields of life sciences, so-called designed studies are used for studying complex biological systems. The data derived from these studies comply with a study design aimed at generating relevant information while diminishing unwanted variation (noise). Knowledge about the study design can be used to decompose the total data...
article 2009
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Radonjic, M. (author), de Haan, J.R. (author), van Erk, M.J. (author), van Dijk, K.W. (author), van den Berg, S.A.A. (author), de Groot, P.J. (author), Müller, M. (author), van Ommen, B. (author), TNO Kwaliteit van Leven (author)
Background: Excessive exposure to dietary fats is an important factor in the initiation of obesity and metabolic syndrome associated pathologies. The cellular processes associated with the onset and progression of diet-induced metabolic syndrome are insufficiently understood. Principal Findings: To identify the mechanisms underlying the...
article 2009
Searched for: author:"van den Berg, S.A.A."
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