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Leeman, W.R. (author), van den Berg, K.J. (author), Houben, G.F. (author), TNO Kwaliteit van Leven (author)The human risk assessment of feed contaminants has often been hampered by a lack of knowledge concerning their behaviour when consumed by livestock. To gain a better understanding of the transfer of contaminants from animal feed to animal products, a meta-analysis of public literature was made. Data concerning feed contaminant concentrations,...article 2007
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van den Berg, K.J. (author), Lammers, J.H.C.M. (author), Hoogendijk, E.M.G. (author), Kulig, B.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Adult male WAG/Rij/MBL rats were dosed with lead acetate at 0, 4.0, 8.0 or 12.5 mg/kg, 5 days per week for 4 weeks. Animals were assessed prior to exposure, at the end of the 4-week exposure period and after a 2-week recovery period using a functional observational battery (FOB) and motor activity assessment. Rats were sacrificed two weeks after...article 1996
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Morse, D.C. (author), Plug, A. (author), Wesseling, W. (author), van den Berg, K.J. (author), Brouwer, A. (author), TNO Voeding (author)Pregnant Wistar WU rats were exposed to 0, 5, and 25 mg of the commercial polychlorinated biphenyl (PCB) mixture Aroclor 1254 per kilogram of body weight on Days 10 to 16 of gestation. Pregnant rats were sacrificed on Gestation Day 20 to observe effects on fetal body and brain weights. Male and female offspring were sacrificed on Postnatal Days...article 1996
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- van den Berg, K.J. (author), Gramsbergen, J-B.P. (author), Hoogendijk, E.M.G. (author), Lammers, J.H.C.M. (author), Sloot, W.S. (author), Kulig, B.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author) conference paper 1995
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- van den Berg, K.J. (author), Gramsbergen, J.B.P. (author), Hoogendijk, E.M.G. (author), Lammers, J.H.C.M. (author), Sloot, W.N. (author), Kulig, B.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author) conference paper 1995
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van Raaij, J.A.G.M. (author), Frijters, C.M.G. (author), Wong Yen Kong, L. (author), van den Berg, K.J. (author), Notten, W.R.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)In the present study the effects of hexachlorobenzene (HCB) and the metabolite pentachlorophenol (PCP) were investigated with respect to uptake of thyroxine (T4) into cerebrospinal fluid (CSF) and brain structures of rats. [125I]T4 was taken up into CSF of control rats by a relatively slow process, reaching a steady state after about 3 h. Both...article 1994
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- van Nesselrooij, J.H.J. (author), Kuper, C.F. (author), Feron, V.J. (author), van den Berg, K.J. (author), Hoogendijk, E.M.G. (author), Kulig, B.M. (author), Cassee, F.R. (author), Groten, J.P. (author), Roggeband, R. (author), van den Berg, P.T.M. (author), Steenwinkel, M-J.S.T. (author), van Delft, J.H.M. (author), Baan, R.A. (author), Rompelberg, J.J.M. (author), van den Heuvel, P.D. (author), Bruijntjes-Rozier, T.C.D.M. (author), Leeman, R.R. (author), Verhagen, H. (author), van de Sandt, J.J.M. (author), Bos, T.A. (author), Rutten, A.A.J.J.L. (author), Sloot, W.N. (author), Gramsbergen, J.B.P. (author), Velthuis-te Wierik, E.J.M. (author), de Vogel, N. (author), Wolterbeek, A.P.M. (author), Schoevers, E.J. (author), van Moorsel, C.J.A. (author) article 1994
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- Sauer, P.J.J. (author), Huisman, M. (author), Koopman-Esseboom, C. (author), Morse, D.C. (author), Smits-van Prooije, A.E. (author), van den Berg, K.J. (author), Tuinstra, L.G.M.T. (author), van der Paauw, C.G. (author), Boersma, E.R. (author), Weisglas-Kuperus, N. (author), Lammers, J.H.C.M. (author), Kulig, B.M. (author), Brouwer, A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author) article 1994
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van Raaij, J.A.G.M. (author), Kaptein, E. (author), Visser, T.J. (author), van den Berg, K.J. (author), Medisch Biologisch Laboratorium TNO (author)Metabolism of thyroid hormones was investigated in WAG/MBL rats that had been exposed to hexachlorobenzene (HCB). Serum thyroxine (T4) levels were lowered by 35.5%, whereas triiodothyronine (T3) levels were not changed. Bile flow, as well as T4 excretion in bile were increased by HCB treatment. Analysis of bile by HPLC revealed a more than 3...article 1993
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- Morse, D.C. (author), Wesseling, W. (author), Brouwer, A. (author), van den Berg, K.J. (author), Medisch Biologisch Laboratorium TNO Centraal Instituut voor Voedingsonderzoek TNO (author) conference paper 1993
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- van Raaij, J.A.G.M. (author), Frijters, C.M.G. (author), van den Berg, K.J. (author), Medisch Biologisch Laboratorium TNO Centraal Instituut voor Voedingsonderzoek TNO (author) article 1993
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van den Berg, K.J. (author), Gramsbergen, J.B.P. (author), Medisch Biologisch Laboratorium TNO Centraal Instituut voor Voedingsonderzoek TNO (author)Chemicals/CAS: calcium, 7440-70-2; kainic acid, 487-79-6; Biological Markers; Calcium, 7440-70-2; Glial Fibrillary Acidic Protein; Kainic Acid, 487-79-6; Neurotoxinsarticle 1993
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- Visser, T.J. (author), Kaptein, E. (author), van Raaij, J.A.G.M. (author), van den Berg, K.J. (author), Tjong Tjin Joe, C. (author), van Engelen, G.M. (author), Brouwer, A. (author), Medisch Biologisch Laboratorium TNO Centraal Instituut voor Voedingsonderzoek TNO (author) article 1993
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van Raaij, J.A.G.M. (author), van den Berg, K.J. (author), Notten, W.R.F. (author), Medisch Biologisch Laboratorium TNO (author)Previous results have indicated that hexachlorobenzene (HCB)-induced hypothyroidism may be caused by its main metabolite pentachlorophenol (PCP), and by tetrachlorohydroquinone (TCHQ), rather than by the parent compound. In the present experiments it was investigated whether hormone displacement from serum carriers could be a factor in the...article 1991
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van den Berg, K.J. (author), van Raaij, J.A.G.M. (author), Bragt, P.C. (author), Notten, W.R.F. (author), Medisch Biologisch Laboratorium TNO (author)Previous results in experimental systems have suggested that hydroxylated PCBs may decrease thyroid hormone levels through associative interaction with transthyretin. In the present paper it was investigated whether this property was also shared by various industrial chemicals, mainly pesticides. In total, 65 compounds from 12 chemical groups...article 1991
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Medisch Biologisch Laboratorium TNO (author), van den Berg, K.J. (author)Previous results (Brouwer and van den Berg, Toxicol. Appl. Pharmacol., 85 (1986) 301) indicated preferential binding of a hydroxylated metabolite of tetrachlorobiphenyl to transthyretin (TTR) a carrier of thyroxine (T4). In the present study it was investigated whether the T4 binding site of TTR could be occupied specifically by hydroxylated...article 1990
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- Radiobiologisch Instituut TNO (author), Hermens, A.F. (author), Korving, R. (author), de Leeuw, A.M. (author), van den Berg, K.J. (author) article 1986
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Krump-Konvalinkova, V. (author), van den Berg, K.J. (author), Radiobiologisch Instituut TNO (author)All normal cells are thought to carry genetic information for oncogenic transformation, which, on activation to continuous expression. might make the cell cancerous. The presently known transforming retroviruses contain transforming genes which were probably derived by recombination of a slow oncogenic retrovirus with cellular sequences closely...article 1980
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Radiobiologisch Instituut TNO (author), van den Berg, K.J. (author), Betel, I. (author)Chemicals/CAS: 2 amino 2 methylpropionic acid, 62-57-7; amino acid, 65072-01-7; concanavalin A, 11028-71-0; sodium, 7440-23-5; Amino Acids; Aminoisobutyric Acids; Concanavalin A, 11028-71-0; Cyclopentanes; Sodium, 7440-23-5article 1973
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van den Berg, K.J. (author), Betel, I. (author), Radiobiologisch Instituut TNO (author)Chemicals/CAS: 2 amino 2 methylpropionic acid, 62-57-7; carbon, 7440-44-0; thymidine, 50-89-5; tritium, 10028-17-8; Aminoisobutyric Acids; Carbon Isotopes; Lectins; Thymidine, 50-89-5; Tritium, 10028-17-8article 1971