Hazard identification of chemicals: A more efficient approach

The OECD (organisation for economic co-operation and development) guidelines for hazard identification of chemicals have proved their worth in practice and are of great significance for designing adequate and relevant toxicity studies. However, assessment procedures are too time-consuming and too expensive. Thus, there is a need for a more...

Exposure to combinations of substances: A system for assessing health risks

Combined exposures may be categorised as specified combinations or mixtures of substances, depending on composition and exposure scenario. The major characteristic of a specified combination is known composition and that of a mixture simultaneous exposure. A framework was developed as a guide for safety evaluation of combined exposures. This...

International issues on human health effects of exposure to chemical mixtures

In this article, we highlight new developments and recent studies concerning adverse human health effects related to chemical mixtures. One group of activities comprises the development of a new computer program for analyzing mixture studies and a mathematical model as a basis for combination rules that predict the toxicity of mixtures. Other...

Summary of the report 'Toxicology-Based Recommended Exposure Limits'

Current advances from Europe: risk assessment of peak exposure to genotoxic carcinogens : summary of a report

Toxicologische advieswaarden voor blootstelling aan stoffen [Toxicology-based recommended exposure limits]

Risk assessment of peak exposure to genotoxic carcinogens