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van Herpen-Broekmans, W. (author), Klöpping-Ketelaars, I. (author), Michiel, B. (author), Cornelis, K. (author), Hans, P. (author), Hendriks, F.J. (author), Tijburg, L. (author), van Poppel, G. (author), Kardinaal, A. (author), TNO Preventie en Gezondheid (author)Background: Endothelial cell dysfunction may be related to an increase in cellular oxidative stress. Carotenoids and vitamins could have an antioxidant-mediated tempering influence on endothelial function and inflammation, thereby reducing the risk of atherosclerosis. Methods: We measured serum carotenoids, α-tocopherol and Vitamin C...article 2004
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Broekmans, W.M.R. (author), Klöpping-Ketelaars, I.A.A. (author), Weststrate, J.A. (author), Tijburg, L.B.M. (author), van Poppel, G. (author), Vink, A.A. (author), Berendschot, T.T.J.M. (author), Bots, M.L. (author), Castenmiller, W.A.M. (author), Kardinaal, A.F.M. (author)Excessive consumption of energy and fat increases the risk for obesity. Snacks containing sucrose polyesters (SPE) as a dietary fat replacer are on the market in the United States. SPE products have been shown to lower concentrations of serum carotenoids in short-term studies. Experimental studies on the longer-term effects on health of...article 2003
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Witte, D.R. (author), Broekmans, W.M.R. (author), Kardinaal, A.F.M. (author), Klöpping-Ketelaars, I.A.A. (author), van Poppel, G. (author), Bots, M.L. (author), Kluft, C. (author), Princen, J.M.G. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)Background: Flow mediated dilatation (FMD) of the brachial artery and soluble intercellular adhesion molecule 1 (sICAM-1) are measures of distinct functions of the endothelium, reflecting nitric oxide (NO)-mediated and pro-inflammatory status, respectively. The comparative value of the two measures in relation to cardiovascular risk is unknown....article 2003
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Broekmans, W.M.R. (author), Vink, A.A. (author), Boelsma, E. (author), Klöpping-Ketelaars, W.A.A. (author), Tijburg, L.B.M. (author), van 't Veer, P. (author), van Poppel, G. (author), Kardinaal, A.F.M. (author), TNO Voeding (author)Background: Acute effects of UV irradiation include UV-induced erythema. Sunlight plays an important role in the development of skin cancer. Several predictive factors of UV-induced erythema could also be predictive for skin cancer. Objective: Our objective was to quantitatively assess phenotypical and nutritional determinants of sensitivity to...article 2003
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Berendschot, T.T.J.M. (author), Broekmans, W.M.R. (author), Klöpping-Ketelaars, I.A.A. (author), Kardinaal, A.F.M. (author), van Poppel, G. (author), van Norren, D. (author), TNO Technische Menskunde (author)Objective: To investigate whether nutritional factors and possible risk factors for cataract influence the lens optical density (LOD). Design: Three hundred seventy-six subjects, aged 18 to 75 years, were recruited. In a cross-sectional design, serum was analyzed for lutein, zeaxanthin, vitamin C, α-tocopherol, and cholesterol levels. Adipose...article 2002
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Broekmans, W.M.R. (author), Berendschot, T.T.J.R. (author), Klöpping-Ketelaars, I.A.A. (author), de Vries, A.J. (author), Goldbohm, R.A. (author), Tijburg, L.B.M. (author), Kardinaal, A.F.M. (author), van Poppel, G. (author), TNO Voeding (author)Background: Macular pigment (MP), concentrated in the central area of the retina, contains the carotenoids lutein and zeaxanthin. A low MP density could be a risk factor for age-related macular degeneration. Little information is available regarding MP density in relation to serum lutein and zeaxanthin and adipose lutein concentrations in a...article 2002
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- Broekmans, W.M.R. (author), Klöpping-Ketelaars, W.A.A. (author), Kluft, C. (author), van den Berg, H. (author), Kok, F.J. (author), van Poppel, G. (author), TNO Voeding (author) article 2001
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Diplock, A.T. (author), van Poppel, G. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Chemicals/CAS: Antioxidants; Vitaminsarticle 2001
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van Poppel, G. (author), Verhoeven, D.T.H. (author), Verhagen, H. (author), Goldbohm, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)This paper first gives an overview of the epidemiological data concerning the cancer-preventive effect of brassica vegetables, including cabbages, kale, broccoli, Brussels sprouts, and cauliflower. A protective effect of brassicas against cancer may be plausible due to their relatively high content of glucosinolates. Certain hydrolysis products...article 2000
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van de Vijver, L.P.L. (author), Kardinaal, A.F.M. (author), Couet, C. (author), Aro, A. (author), Kafatos, A. (author), Steingrimsdottir, L. (author), Amorim Cruz, J.A. (author), Moreiras, O. (author), Becker, W. (author), van Amelsvoort, J.M.M. (author), Vidal-Jessel, S. (author), Salminen, I. (author), Moschandreas, J. (author), Sigfússon, N. (author), Martins, I. (author), Carbajal, A. (author), Ytterfors, A. (author), van Poppel, G. (author)Background: High intakes of trans fatty acids (TFA) have been found to exert an undersirable effect on serum lipid profiles, and thus may increase the risk for cardiovascular disease. Objective: Investigation of the association between TFA intake and serum lipids. Design: Cross-sectional study in eight European countries (Finland, France, Greece...article 2000
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Broekmans, W.M.R. (author), Klöpping-Ketelaars, I.A.A. (author), Schuurman, C.R.W.C. (author), Verhagen, H. (author), van den Berg, H. (author), Kok, F.J. (author), van Poppel, G. (author), TNO Voeding (author)Observational epidemiologic studies have shown that a high consumption of fruits and vegetables is associated with a decreased risk of chronic diseases. Little is known about the bioavailability of constituents from vegetables and fruits and the effect of these constituents on markers for disease risk. Currently, the recommendation is to...article 2000
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Voorrips, L.E. (author), Goldbohm, R.A. (author), van Poppel, G. (author), Sturmans, F. (author), Hermus, R.J.J. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The relation between vegetable and fruit consumption and colorectal cancer risk was comprehensively assessed in the Netherlands Cohort Study on Diet and Cancer using a validated 150-item food frequency questionnaire. After 6.3 years of follow-up (1986-1992), over 1,000 incident cases of colorectal cancer were registered. Using case-cohort...article 2000
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- van Poppel, G. (author) article 1999
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- van de Vijver, L.P.L. (author), Kardinaal, A.F.M. (author), van Duyvenvoorde, W. (author), Kruijssen, D.A.C.M. (author), Grobbee, D.E. (author), van Poppel, G. (author), Princen, H.M.G. (author) article 1999
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- van Poppel, G. (author), Verhoeven, D.T.H. (author), Verhagen, H. (author), Goldbohm, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author) bookPart 1999
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Hulshof, K.F.A.M. (author), Erp van - Baart, M.A. (author), Anttolainen, M. (author), Becker, W. (author), Church, S.M. (author), Couet, C. (author), Hermann-Kunz, E. (author), Kesteloot, H. (author), Leth, T. (author), Martins, I. (author), Moreiras, O. (author), Moschandreas, J. (author), Pizzoferrato, L. (author), Rimestad, A.H. (author), Thorgeirsdottir, H. (author), van Amelsvoort, J.M.M. (author), Aro, A. (author), Kafatos, A.G. (author), Lanzmann-Petithory, D. (author), van Poppel, G. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Objective: To assess the intake of trans fatty acids (TFA) and other fatty acids in 14 Western European countries. Design and subjects: A maximum of 100 foods per country were sampled and centrally analysed. Each country calculated the intake of individual trans and other fatty acids, clusters of fatty acids and total fat in adults and/or the...article 1999
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- Woutersen, R.A. (author), Verhagen, H. (author), van Poppel, G. (author), Goldbohm, R.A. (author) article 1999
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Cashman, J.R. (author), Xiong, Y. (author), Lin, J. (author), Verhagen, H. (author), van Poppel, G. (author), van Bladeren, P.J. (author), Larsen-Su, S. (author), Williams, D.E. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The effect of consumption of glucosinolate-containing Brussels sprouts on flavin-containing monooxygenase functional activity in humans was investigated in 10 healthy, male, non-smoking volunteers. After a 3-week run-in period, 5 volunteers continued on a glucosinolate-free diet for 3 weeks (control group), and 5 others consumed 300 g of cooked...article 1999
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van de Vijver, L.P.L. (author), Kardinaal, A.F.M. (author), van Duyvenvoorde, W. (author), Kruijssen, D.A.C.M. (author), Grobbee, D.E. (author), van Poppel, G. (author), Princen, H.M.G. (author), TNO Preventie en Gezondheid (author)Evidence has accumulated for oxidative modification of low-density lipoproteins (LDL) to play an important role in the atherogenic process. Therefore, we investigated the relation between susceptibility of LDL to oxidation and risk of peripheral atherosclerosis among 249 men between 45 and 80 years of age. The ankle-arm index was calculated for...article 1999
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- Cashman, J.R. (author), Xiong, Y. (author), Lin, J. (author), Verhagen, H. (author), van Poppel, G. (author), van Bladeren, P.J. (author), Larsen-Su, S. (author), Williams, D.E. (author) article 1999