Searched for: author%3A%22van+Osch%2C+G.J.V.M.%22
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Wei, W. (author), Bastiaanen-Jenniskens, Y.M. (author), Suijkerbuik, M. (author), Kops, N. (author), Bos, P.K. (author), Verhaar, J.A.M. (author), Zuurmond, A.M. (author), Dell'Accio, F. (author), van Osch, G.J.V.M. (author)
Obesity is a well-known risk factor for osteoarthritis, but it is unknown what it does on cartilage repair. Here we investigated whether a high fat diet (HFD) influences cartilage repair in a mouse model of cartilage repair. We fed DBA/1 mice control or HFD (60% energy from fat). After 2 weeks, a full thickness cartilage defect was made in the...
article 2017
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de Jong, A.J. (author), Klein-Wietinga, I.R. (author), Andersen, S.N. (author), Kwekkeboom, J.C. (author), Herb-van Toorn, L. (author), de Lange-Brokaar, B.J.E. (author), van Delft, D. (author), Garcia, J. (author), Wei, W. (author), van der Heide, H.J.L. (author), Bastiaanen-Jenniskens, Y.M. (author), van Osch, G.J.V.M. (author), Zuurmond, A.M. (author), Stojanovic-Susulic, V. (author), Nelissen, R.G. (author), Toes, R.E.M. (author), Kloppenburg, M. (author), Ioan-Facsinay, A. (author)
Background. Obesity is associated with the development and progression of osteoarthritis (OA). Although the infrapatellar fat pad (IFP) could be involved in this association, due to its intracapsular localization in the knee joint, there is currently little known about the effect of obesity on the IFP. Therefore, we investigated cellular and...
article 2017
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van Tiel, J. (author), Siebelt, M. (author), Reijman, M. (author), Bos, P.K. (author), Waarsing, J.H. (author), Zuurmond, A.M. (author), Nasserinejad, K. (author), van Osch, G.J.V.M. (author), Verhaar, J.A.N. (author), Krestin, G.P. (author), Weinans, H. (author), Oei, E.H.G. (author)
Objective. Recently, computed tomography arthrography (CTa) was introduced as quantitative imaging biomarker to estimate cartilage sulphated glycosaminoglycan (sGAG) content in human cadaveric knees. Our aim was to assess the correlation between in vivo CTa in human osteoarthritis (OA) knees and ex vivo reference standards for sGAG and collagen...
article 2016
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de Lange-Brokaar, B.J.E. (author), Ioan-Facsinay, A. (author), Yusuf, E. (author), Visser, A.W. (author), Kroon, H.M. (author), van Osch, G.J.V.M. (author), Zuurmond, A.M. (author), Stojanovic-Susulic, V. (author), Bloem, J.L. (author), Nelissen, R.G.H.H. (author), Huizinga, T.W. (author), Kloppenburg, M. (author)
Objective To determine possible patterns of synovitis on contrast-enhanced magnetic resonance imaging (CE-MRI) and its relation to pain and severity in patients with radiographic knee osteoarthritis (OA). Methods In total, 86 patients (mean age 62 years, 66% women, median body mass index 29 kg/m2) with symptomatic knee OA (Kellgren/Lawrence...
article 2015
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de Lange-Brokaar, B.J.E. (author), Ioan-Facsinay, A. (author), Yusuf, E. (author), Visser, A.W. (author), Kroon, H.M. (author), Andersen, S.N. (author), Herb-van Toorn, L. (author), van Osch, G.J.V.M. (author), Zuurmond, A.M. (author), Stojanovic-Susulic, V. (author), Bloem, J.L. (author), Nelissen, R.G.H.H. (author), Huizinga, T.W.J. (author), Kloppenburg, M. (author)
Objective: To evaluate the association between synovitis on contrast enhanced (CE) MRI with microscopic and macroscopic features of synovial tissue inflammation. Method: Forty-one patients (mean age 60 years, 61% women) with symptomatic radiographic knee OA were studied: twenty underwent arthroscopy (macroscopic features were scored (0-4),...
article 2014
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Wei, W. (author), Clockaerts, S. (author), Bastiaansen-Jenniskens, Y.M. (author), Gierman, L.M. (author), Botter, S.M. (author), Bierma-Zeinstra, S.M.A. (author), Weinans, H. (author), Verhaar, J.A.N. (author), Kloppenburg, M. (author), Zuurmond, A.M. (author), van Osch, G.J.V.M. (author)
Objective: Since statins and fibrates are capable of improving the metabolic profile of patients as well as decreasing inflammation, they are considered as potential drugs for preventing osteoarthritis (OA). The goal of the present study was to investigate the effect of these drugs in the STR/Ort spontaneous OA mouse model. Design: Male STR/Ort...
article 2014
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Gierman, L.M. (author), Kühnast, S. (author), Koudijs, A. (author), Pieterman, E.J. (author), Kloppenburg, M. (author), van Osch, G.J.V.M. (author), Stojanovic-Susulic, V. (author), Huizinga, T.W.J. (author), Princen, H.M.G. (author), Zuurmond. A.M., (author)
Objective Hypercholesterolaemia, a risk factor for atherosclerosis (ATH), has been suggested to have a role in the development of osteoarthritis (OA). To test this hypothesis, the effect of cholesterol and different cholesterol-lowering treatments on OA was investigated in a mouse model resembling human lipoprotein metabolism. Methods Female...
article 2014
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Gierman, L.M. (author), Wopereis, S. (author), van El, B. (author), Verheij, E.R. (author), Werff-Van Der Vat, B.J.C. (author), Bastiaansen-Jenniskens, Y.M. (author), van Osch, G.J.V.M. (author), Kloppenburg, M. (author), Stojanovic-Susulic, V. (author), Huizinga, T.W.J. (author), Zuurmond, A.M. (author)
Objective The infrapatellar fat pad (IPFP) in the knee joint is hypothesized to contribute to osteoarthritis (OA) development by the IFPF possibly by influencing inflammatory processes. Oxylipins are essential mediators in the inflammatory process. We undertook this study to investigate secretion by the IFPF of fatty acids and oxylipins derived...
article 2013
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Bastiaansen-Jenniskens, Y.M. (author), Siawash, M. (author), van de Lest, C.H.A. (author), Verhaar, J.A.N. (author), Kloppenburg, M. (author), Zuurmond, A.M. (author), Stojanovic-Susulic, V. (author), van Osch, G.J.V.M. (author), Clockaerts, S. (author)
Purpose: Osteoarthritis (OA) is associated with obesity in which altered fatty acid levels have been observed. We investigated whether the most common fatty acids in synovial fluid influence cartilage deterioration in OA. Design: Cartilage was obtained from OA patients undergoing total knee arthroplasty. Chondrocytes or cartilage explants were...
article 2013
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Beekhuizen, M. (author), Gierman, L.M. (author), van Spil, W.E. (author), van Osch, G.J.V.M. (author), Huizinga, T.W.J. (author), Saris, D.B.F. (author), Creemers, L.B. (author), Zuurmond, A.-M. (author)
Objective: Soluble mediators in synovial fluid (SF) are acknowledged as key players in the pathophysiology of osteoarthritis (OA). However, a wide-spectrum screening of such mediators in SF is currently lacking. In this study, the levels of 47 mediators in the SF of control donors and osteoarthritic (OA) patients were compared. Materials &...
article 2013
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Gierman, L.M. (author), van El, B. (author), van der Ham, F. (author), Koudijs, A. (author), Stoop, R. (author), Verheijen, J.H. (author), Kloppenburg, M. (author), van Osch, G.J.V.M. (author), Stojanovic-Susulic, V. (author), Huizinga, T.W.J. (author), Zuurmond, A.M. (author)
Objective:Evidence is accumulating that synovial tissue plays an active role in osteoarthritis (OA), however, exact understanding of its contribution is lacking. In order to further elucidate its role in the OA process, we aimed to identify the secretion pattern of soluble mediators by synovial tissue and to assess its ability to initiate...
article 2013
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de Lange-Brokaar, B.J.E. (author), Ioan-Facsinay, A. (author), van Osch, G.J.V.M. (author), Zuurmond, A.-M. (author), Schoones, J. (author), Toes, R.E.M. (author), Huizinga, T.W.J. (author), Kloppenburg, M. (author)
Objective: Although osteoarthritis (OA) is considered a non-inflammatory condition, it is widely accepted that synovial inflammation is a feature of OA. However, the role of immune cells and their cytokines in OA is largely unknown. This narrative systematic review summarizes the knowledge of inflammatory properties, immune cells and their...
article 2012
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Gierman, L.M. (author), van der Ham, F. (author), Koudijs, A. (author), Wielinga, P.Y. (author), Kleemann, R. (author), Kooistra, T. (author), Stoop, R. (author), Kloppenburg, M. (author), van Osch, G.J.V.M. (author), Stojanovic-Susulic, V. (author), Huizinga, T.W. (author), Zuurmond, A.M. (author)
article 2012
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Bastiaansen-Jenniskens, Y.M. (author), Clockaerts, S. (author), Feijt, C. (author), Zuurmond, A.M. (author), Stojanovic-Susulic, V. (author), Bridts, C. (author), de Clerck, L. (author), de Groot, J. (author), Verhaar, J.A.N. (author), Kloppenburg, M. (author), van Osch, G.J.V.M. (author)
Objective: Adipose tissue is known to release inflammatory cytokines and growth factors. In this exploratory study, the authors examined whether the infrapatellar fat pad (IPFP) closely located to cartilage in the knee joint can affect cartilage metabolism. In addition, the authors analysed whether the macrophage types present in IPFP could...
article 2012
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Clockaerts, S. (author), Bastiaansen-Jenniskens, Y.M. (author), Feijt, C. (author), Clerck, L.de (author), Verhaar, J.A.N. (author), Zuurmond, A.M. (author), Stojanovic-Susulic, V. (author), Somville, J. (author), Kloppenburg, M. (author), van Osch, G.J.V.M. (author)
Background: Infrapatellar fat pad (IPFP) might be involved in osteoarthritis (OA) by production of cytokines. It was hypothesised that production of cytokines is sensitive to environmental conditions. Objectives: To evaluate cytokine production by IPFP in response to interleukin (IL)1β and investigate the ability to modulate this response with...
article 2012
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Klein-Wieringa, I.R. (author), Kloppenburg, M. (author), Bastiaansen-Jenniskens, Y.M. (author), Yusuf, E. (author), Kwekkeboom, J.C. (author), El-Bannoudi, H. (author), Nelissen, R.G.H.H. (author), Zuurmond, A. (author), Stojanovic-Susulic, V. (author), van Osch, G.J.V.M. (author), Toes, R.E.M. (author), Ioan-Facsinay, A. (author)
Objectives: Obesity is a risk factor for the development of osteoarthritis (OA) in hands and knees. Adipose tissue can secrete different adipokines with powerful immunomodulatory effects. The infrapatellar fat pad (IFP) is an intra-articular organ in the vicinity of the synovium and cartilage. It is hypothesised that IFP-derived soluble factors...
article 2011
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Blumbach, K. (author), Bastiaansen-Jenniskens, Y.M. (author), de Groot, J. (author), Paulsson, M. (author), van Osch, G.J.V.M. (author), Zaucke, F. (author), TNO Kwaliteit van Leven (author)
Objective. Defects in the assembly and composition of cartilage extracellular matrix are likely to result in impaired matrix integrity and increased susceptibility to cartilage degeneration. The aim of this study was to determine the functional interaction of the collagen fibril-associated proteins type IX collagen and cartilage oligomeric...
article 2009
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Bastiaansen-Jenniskens, Y.M. (author), Koevoet, W. (author), de Bart, A.C.W. (author), van der Linden, J.C. (author), Zuurmond, A.M. (author), Weinans, H. (author), Verhaar, J.A.N. (author), van Osch, G.J.V.M. (author), de Groot, J. (author), TNO Kwaliteit van Leven (author)
Background: Damage to articular cartilage is one of the features of osteoarthritis (OA). Cartilage damage is characterised by a net loss of collagen and proteoglycans. The collagen network is considered highly important for cartilage function but little is known about processes that control composition and function of the cartilage collagen...
article 2008
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TNO Kwaliteit van Leven (author), Bastiaansen-Jenniskens, Y.M. (author), Koevoet, W. (author), de Bart, A.C.W. (author), Zuurmond, A.M. (author), Bank, R.A. (author), Verhaar, J.A.N. (author), de Groot, J. (author), van Osch, G.J.V.M. (author)
Transforming growth factor beta (TGFbeta) is often used in cartilage tissue engineering to increase matrix formation by cells with various phenotypes. However, adverse effects of TGFbeta, such as extensive cross-linking in cultured fibroblasts, have also been reported. Our goal was to study effects of TGFbeta on collagen cross-linking and...
article 2008
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de Mos, M. (author), van El, B. (author), de Groot, J. (author), Jahr, H. (author), van Schie, H.T.M. (author), van Arkel, E.R. (author), Tol, H. (author), Heijboer, R. (author), van Osch, G.J.V.M. (author), Verhaar, J.A.N. (author), TNO Kwaliteit van Leven (author)
Background: Understanding biochemical and structural changes of the extracellular matrix in Achilles tendinosis might be important for developing mechanism-based therapies. Hypothesis: In Achilles tendinosis, changes occur in biochemical composition and collagen turnover rate. Study Design: Descriptive laboratory study. Methods: From 10 patients...
article 2007
Searched for: author%3A%22van+Osch%2C+G.J.V.M.%22
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