Searched for: author:"van Ommen, B."
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de Hoogh, I.M. (author), Oosterman, J.E. (author), Otten, W. (author), Krijger, A.M. (author), Berbée-Zadelaar, S. (author), Pasman, W.J. (author), van Ommen, B. (author), Pijl, H. (author), Wopereis, S. (author)
Although lifestyle interventions can lead to diabetes remission, it is unclear to what extent type 2 diabetes (T2D) remission alters or improves the underlying pathophysiology of the disease. Here, we assess the effects of a lifestyle intervention on T2D reversal or remission and the effects on the underlying pathology. In a Dutch primary care...
article 2021
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Molema, H. (author), van Erk, M. (author), van Ommen, B. (author), Pijl, H. (author), Wopereis, S. (author), Kiefte-de Jong, J. (author), Chavannes, N. (author), Kremer, B. (author), van Bilsen, J. (author), van Winkelhof, M. (author)
Op dit moment is sprake van een COVID-19-pandemie met grote persoonlijke, medische, maatschappelijke en financieel-economische schade. Landen en zorgsystemen gaan tot het uiterste om de COVID-19-uitbraak het hoofd te bieden. In Nederland kunnen we daarbij bouwen op een zeer goed zorgsysteem, zowel in de intensieve zorg (intensive care,...
report 2020
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van den Brink, W. (author), van Bilsen, J. (author), Salic, K. (author), Hoevenaars, F.P.M. (author), Verschuren, L. (author), Kleemann, R. (author), Bouwman, J. (author), van Ommen, B. (author), Wopereis, S. (author)
Obesity, type 2 diabetes, and other metabolic disorders have a large impact on global health, especially in Western countries. An important hallmark of metabolic disorders is chronic low-grade inflammation. A key player in chronic low-grade inflammation is dysmetabolism, which is defined as the inability to keep homeostasis resulting in loss of...
article 2019
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Molema, H. (author), van Erk, M. (author), van Winkelhof, M. (author), van 't Land, K. (author), Kiefte-de Jong, J. (author), van Ommen, B. (author), Pijl, H. (author), Cahn, W. (author), Deenik, J. (author), Maljaars, J. (author), van der Boog, P. (author), van Laarhoven, K. (author), de Reuver, P. (author), van Rossum, L. (author), Hoenders, R. (author), van Schaardenburg, D. (author), Wopereis, S. (author), Bonten, T. (author), Vos, R. (author), Navis, G. (author), Olde Rikkert, M. (author), Kraaijenhagen, R. (author), Preller, L. (author), Stronks, K. (author)
Dat leefstijl van groot belang is om gezond te zijn en te blijven, weten de meeste Nederlanders wel. Maar dat leefstijlinterventies effectief ingezet kunnen worden voor herstel of behandeling van ziekten is minder bekend. Daarom richten wij ons bij het Nederlands Innovatiecentrum voor Leefstijlgeneeskunde juist daarop, dat doen we onder de naam...
book 2019
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Shankar, K. (author), Pivik, R.T. (author), Johnson, S.L. (author), van Ommen, B. (author), Demmer, E. (author), Murray, R. (author)
Understanding health requires more than knowledge of the genome. Environmental factors regulate gene function through epigenetics. Collectively, environmental exposures have been called the "exposome." Caregivers are instrumental in shaping exposures in a child's initial years. Maternal dietary patterns, physical activity, degree of weight gain,...
article 2018
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Jiménez-Lucena, R. (author), Camargo, A. (author), Alcalá-Diaz, J.F. (author), Romero-Baldonado, C. (author), Luque, R.M. (author), van Ommen, B. (author), Delgado-Lista, J. (author), Ordovás, J.M. (author), Pérez-Martínez, P. (author), Rangel-Zúñiga, O.A. (author), López-Miranda, J. (author)
We aimed to explore whether changes in circulating levels of miRNAs according to type 2 diabetes mellitus (T2DM) or prediabetes status could be used as biomarkers to evaluate the risk of developing the disease. The study included 462 patients without T2DM at baseline from the CORDIOPREV trial. After a median follow-up of 60 months, 107 of the...
article 2018
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Fiamoncini, J. (author), Rundle, M. (author), Gibbons, H. (author), Thomas, E.L. (author), Geillinger-Kästle, K. (author), Bunzel, D. (author), Trezzi, J.P. (author), Kiselova-Kaneva, Y. (author), Wopereis, S. (author), Wahrheit, J. (author), Kulling, S.E. (author), Hiller, K. (author), Sonntag, D. (author), Ivanova, D. (author), van Ommen, B. (author), Frost, G. (author), Brennan, L. (author), Bell, J. (author), Daniel, H. (author)
Health has been defined as the capability of the organism to adapt to challenges. In this study,we tested to what extent comprehensively phenotyped individuals reveal differences in metabolic responses to a standardized mixed meal tolerance test (MMTT) and how these responses change when individuals experience moderate weight loss. Metabolome...
article 2018
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van Ommen, B. (author), Wopereis, S. (author), van Empelen, P. (author), van Keulen, H.M. (author), Otten, W. (author), Kasteleyn, M. (author), Molema, J.J.W. (author), de Hoogh, I.M. (author), Chavannes, N.H. (author), Numans, M.E. (author), Evers, A.W.M. (author), Pijl, H. (author)
From a biological view, most of the processes involved in insulin resistance, which drives the pathobiology of type 2 diabetes, are reversible. This theoretically makes the disease reversible and curable by changing dietary habits and physical activity, particularly when adopted early in the disease process. Yet, this is not fully implemented...
article 2018
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Wopereis, S. (author), Stroeve, J.H.M. (author), Stafleu, A. (author), Bakker, G.C.M. (author), Burggraaf, J. (author), van Erk, M.J. (author), Pellis, L. (author), Boessen, R. (author), Kardinaal, A.A.F. (author), van Ommen, B. (author)
Background: A key feature of metabolic health is the ability to adapt upon dietary perturbations. Recently, it was shown that metabolic challenge tests in combination with the new generation biomarkers allow the simultaneous quantification of major metabolic health processes. Currently, applied challenge tests are largely non-standardized. A...
article 2017
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Grimaldi, K.A. (author), van Ommen, B. (author), Ordovas, J.M. (author), Parnell, L.D. (author), Mathers, J.C. (author), Bendik, I. (author), Brennan, L. (author), Celis-Morales, C. (author), Cirillo, E. (author), Daniel, H. (author), de Kok, B. (author), El-Sohemy, A. (author), Fairweather-Tait, S.J. (author), Fallaize, R. (author), Fenech, M. (author), Ferguson, L.R. (author), Gibney, E.R. (author), Gibney, M. (author), Gjelstad, I.M.F. (author), Kaput, J. (author), Karlsen, A.S. (author), Kolossa, S. (author), Lovegrove, J. (author), Macready, A.L. (author), Marsaux, C.F.M. (author), Alfredo Martinez, J. (author), Milagro, F. (author), Navas-Carretero, S. (author), Roche, H.M. (author), Saris, W.H.M. (author), Traczyk, I. (author), van Kranen, H. (author), Verschuren, L. (author), Virgili, F. (author), Weber, P. (author), Bouwman, J. (author)
Nutrigenetic research examines the effects of inter-individual differences in genotype on responses to nutrients and other food components, in the context of health and of nutrient requirements. A practical application of nutrigenetics is the use of personal genetic information to guide recommendations for dietary choices that are more...
article 2017
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van Ommen, B. (author)
public lecture 2017
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Fiamoncini, J. (author), Yiorkas, A.M. (author), Gedrich, K. (author), Rundle, M. (author), Alsters, S.I. (author), Roeselers, G. (author), van den Broek, T.J. (author), Clavel, T. (author), Lagkouvardos, I. (author), Wopereis, S. (author), Frost, G. (author), van Ommen, B. (author), Blakemore, A.I. (author), Daniel, H. (author)
Bile acids (BA) are signaling molecules with a wide range of biological effects, also identified among the most responsive plasma metabolites in the postprandial state. We here describe this response to different dietary challenges and report on key determinants linked to its interindividual variability. Healthy men and women (n = 72, 62 ± 8 yr,...
article 2017
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van Ommen, B. (author), van den Broek, T. (author), de Hoogh, I. (author), van Erk, M. (author), van Someren, E. (author), Rouhani-Rankouhi, T. (author), Anthony, J.C. (author), Hogenelst, K. (author), Pasman, W. (author), Boorsma, A. (author), Wopereis, S. (author)
Personalized nutrition is fast becoming a reality due to a number of technological, scientific, and societal developments that complement and extend current public health nutrition recommendations. Personalized nutrition tailors dietary recommendations to specific biological requirements on the basis of a person’s health status and goals. The...
article 2017
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Blanco-Rojo, R. (author), Perez-Martinez, P. (author), Lopez-Moreno, J. (author), Martinez-Botas, J. (author), Delgado-Lista, J. (author), Van-Ommen, B. (author), Yubero-Serrano, E. (author), Camargo, A. (author), Ordovas, J.M. (author), Perez-Jimenez, F. (author), Gomez-Coronado, D. (author), Lopez-Miranda, J. (author)
This prospective study evaluated whether baseline cholesterol efflux is associated with future development of type 2 diabetes (T2DM) in cardiovascular patients. We measured cholesterol efflux in all CORDIOPREV study (NCT00924937) participants free of T2DM at baseline (n = 462) and assessed its relationship with T2DM incidence during a 4.5 years...
article 2017
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van den Broek, T.J. (author), Bakker, G.C.M. (author), Rubingh, C.M. (author), Bijlsma, S. (author), Stroeve, J.H.M. (author), van Ommen, B. (author), van Erk, M.J. (author), Wopereis, S. (author)
Background: A key feature of metabolic health is the ability to adapt upon dietary perturbations. A systemic review defined an optimal nutritional challenge test, the "PhenFlex test" (PFT). Recently, it has been shown that the PFT enables the quantification of all relevant metabolic processes involved in maintaining or regaining homeostasis of...
article 2017
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van Wietmarschen, H. (author), Schroen, Y. (author), Kallen, V. (author), Steijaert, M. (author), de Graaf, A. (author), van Ommen, B. (author), van der Greef, J. (author)
Western science has been strong in measuring details of biological systems such as gene expression levels and metabolite concentrations, and has generally followed a bottom up approach with regard to explaining biological phenomena. Chinese medicine in contrast has evolved as a top down approach in which body and mind is seen as a whole, a...
article 2017
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den Ouden, H. (author), Pellis, L. (author), Rutten, G.E.H.M. (author), Geerars-van Vonderen, I.K. (author), Rubingh, C.M. (author), van Ommen, B. (author), van Erk, M.J. (author), Beulens, J.W.J. (author)
We aimed to identify metabolites to predict patients’ response to glucose lowering treatment during the first 5 years after detection of type 2 diabetes. Metabolites were measured by GC–MS in baseline samples from 346 screen-detected type 2 diabetes patients in the ADDITION-NL study. The response to treatment with metformin and/or sulphonylurea ...
article 2016
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van Ommen, B. (author), Wopereis, S. (author)
Current biomarkers used in health care and in nutrition and health research are based on quantifying disease onset and its progress. Yet, both health care and nutrition should focus on maintaining optimal health, where the related biology is essentially differing from biomedical science. Health is characterized by the ability to continuously...
conference paper 2016
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Blanco-Rojo, R. (author), Alcala-Diaz, J.F. (author), Wopereis, S. (author), Perez-Martinez, P. (author), Quintana-Navarro, G.M. (author), Marin, C. (author), Ordovas, J.M. (author), van Ommen, B. (author), Perez-Jimenez, F. (author), Delgado-Lista, J. (author), Lopez-Miranda, J. (author)
Aims/hypothesis: The aim of the study was to determine whether basal insulin resistance (IR) phenotype (muscle and/or liver) determines the effect of long-term consumption of a Mediterranean diet or a low-fat diet on tissue-specific IR and beta cell function. Methods: The study was performed in 642 patients included in The effect of an olive oil...
article 2016
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Leon-Acuña, A. (author), Alcala-Diaz, J.F. (author), Delgado-Lista, J. (author), Torres-Peña, J.D. (author), Lopez-Moreno, J. (author), Camargo, A. (author), Garcia-Rios, A. (author), Marin, C. (author), Gomez-Delgado, F. (author), Caballero, J. (author), van Ommen, B. (author), Malagon, M.M. (author), Perez-Martinez, P. (author), Lopez-Miranda, J. (author)
Background/aims: Previous evidences have shown the presence of a prolonged and exaggerated postprandial response in type 2 diabetes mellitus (T2DM) and its relation with an increase of cardiovascular risk. However, the response in prediabetes population has not been established. The objective was to analyze the degree of postprandial lipemia...
article 2016
Searched for: author:"van Ommen, B."
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