Searched for: author%3A%22van+Loveren%2C+H.%22
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Schmeits, P.C.J. (author), Schaap, M.M. (author), Luijten, M. (author), van Someren, E. (author), Boorsma, A. (author), van Loveren, H. (author), Peijnenburg, A.A.C.M. (author), Hendriksen, P.J.M. (author)
Transcriptomics in combination with in vitro cell systems is a powerful approach to unravel modes of action of toxicants. An important question is to which extent the modes of action as revealed by transcriptomics depend on cell type, species and study type (in vitro or in vivo). To acquire more insight into this, we assessed the transcriptomic...
article 2015
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van der Veen, J.W. (author), Soeteman-Hernández, L.G. (author), Ezendam, J. (author), Stierum, R. (author), Kuper, F.C. (author), van Loveren, H. (author)
Allergic contact dermatitis (ACD) is a hypersensitivity immune response induced by small protein-reactive chemicals. Currently, the murine local lymph node assay (LLNA) provides hazard identification and quantitative estimation of sensitizing potency. Given the complexity of ACD, a single alternative method cannot replace the LLNA, but it is...
article 2014
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Tonk, E.C.M. (author), de Groot, D.M.G. (author), Wolterbeek, A.P.M. (author), Penninks, A.H. (author), Waalkens-Berendsen, I.D.H. (author), Piersma, A.H. (author), van Loveren, H. (author)
The susceptibility of developing immune system to chemical disruption warrants the assessment of immune parameters in reproductive and developmental testing protocols. In this study, a wide range of immune endpoints was included in an extended one-generation reproduction toxicity study (EOGRTS) design to determine the relative sensitivity of...
article 2013
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Tonk, E.C. (author), Verhoef, A. (author), de la Fonteyne, L.J. (author), Waalkens-Berendsen, I.D. (author), Wolterbeek, A.P.M. (author), van Loveren, H. (author), Piersma, A.H. (author)
article 2011
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Tonk, E.C.M. (author), de Groot, D.M.G. (author), Penninks, A.H. (author), Waalkens-Berendsen, I.D.H. (author), Wolterbeek, A.P.M. (author), Piersma, A.H. (author), van Loveren, H. (author)
Developmental immunotoxicity assessment is considered ready for inclusion in developmental toxicity studies. Further evaluation of proposed and additional assays is needed to determine their utility in assessing developmental immunotoxicity. In this study, a wide range of immunological parameters was included in an extended one-generation...
article 2011
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Vandebriel, R. (author), Callant Cransveld, C. (author), Crommelin, D. (author), Diamant, Z. (author), Glazenburg, B. (author), Joos, G. (author), Kuper, F. (author), Natsch, A. (author), Nijkamp, F. (author), Noteborn, H. (author), Pieters, R. (author), Roberts, D. (author), Roggen, E. (author), Rorije, E. (author), Seed, M. (author), Sewald, K. (author), van den Heuvel, R. (author), van Engelen, J. (author), Verstraelen, S. (author), van Loveren, H. (author)
Respiratory sensitization provides a case study for a new approach to chemical safety evaluation, as the prevalence of respiratory sensitization has increased considerably over the last decades, but animal and/or human experimental/predictive models are not currently available. Therefore, the goal of a working group was to design a road map to...
article 2011
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Tonk, E.C.M. (author), de Groot, D.M.G. (author), Penninks, A.H. (author), Waalkens - Berendsen, I.D.H. (author), Wolterbeek, A.P.M. (author), Slob, W. (author), Piersma, A.H. (author), van Loveren, H. (author), TNO Kwaliteit van Leven (author)
Current developmental and reproductive toxicity protocols include only a limited set of parameters for effects on the developing immune system. In this study, a wide range of immunological parameters were included in a pre- and postnatal developmental toxicity study. Dose-response data were compared to determine the relative sensitivity of...
article 2010
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van de Briel, R.J. (author), Pennings, J.L.A. (author), Baken, K.A. (author), Pronk, T.E. (author), Boorsma, A. (author), Gottschalk, R. (author), van Loveren, H. (author), TNO Kwaliteit van Leven (author)
Many chemicals can induce allergic contact dermatitis. Because evaluation of skin sensitizing potential by animal testing is prohibited for cosmetics, and screening of many chemicals is required within Registration, Evaluation, Authorisation and Restriction of Chemicals, urgent need exists for predictive in vitro assays to identify contact...
article 2010
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de Jong, W.H. (author), Arts, J.H.E. (author), de Klerk, A. (author), Schijf, M.A. (author), Ezendam, J. (author), Kuper, C.F. (author), van Loveren, H. (author), TNO Kwaliteit van Leven (author)
There are currently no validated animal models that can identify low molecular weight (LMW) respiratory sensitizers. The Local Lymph Node Assay (LLNA) is a validated animal model developed to detect contact sensitizers using skin exposure, but all LMW respiratory sensitizers tested so far were also positive in this assay. Discrimination between...
article 2009
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de Jonge, J.D. (author), Ezendam, J. (author), Knippels, L.M.J. (author), Penninks, A.H. (author), Pieters, R. (author), van Loveren, H. (author), TNO Kwaliteit van Leven (author)
Probiotics are claimed to beneficially affect the immune system and their involvement in allergy prevention is being investigated extensively. However, the efficacy of probiotics in allergy prevention remains controversial. We investigated whether the probiotic Lactobacillus casei Shirota (LcS) could modulate the food allergic response against...
article 2008
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Rijnkels, J.M. (author), Smid, T. (author), van den Aker, E.C. (author), Burdorf, A. (author), van Wijk, R.G. (author), Heederik, D.J.J. (author), Houben, G.F. (author), van Loveren, H. (author), Pal, T.M. (author), van Rooy, F.G.B.G.J. (author), van der Zee, J.S. (author)
The Health Council of the Netherlands published a report in which the best procedure and method for recommending health-based occupational exposure limits (OELs) for inhaled allergens were identified by evaluating the scientific state of the art. Many respiratory disorders in the workplace arise from inhalation of substances which can cause...
article 2008
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Arts, J.H.E. (author), de Jong, W.H. (author), van Triel, J.J. (author), Schijf, M.A. (author), de Klerk, A. (author), van Loveren, H. (author), Kuper, C.F. (author), TNO Kwaliteit van Leven (author)
The local lymph node assay (LLNA) is used to test the potential of low molecular weight (LMW) compounds to induce sensitization via the skin. In the present study, a respiratory LLNA was developed. Male BALB/c mice were exposed head/nose-only during three consecutive days for 45, 90, 180, or 360 min/day to various LMW allergens. Ear application ...
article 2008
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de Jonge, J.D. (author), Knippels, L.M.J. (author), Ezendam, J. (author), Odink, J. (author), Penninks, A.H. (author), van Loveren, H. (author), TNO Kwaliteit van Leven (author)
article 2007
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de Jonge, J.D. (author), Knippels, L.M.J. (author), Ezendam, J. (author), Odink, J. (author), Penninks, A.H. (author), van Loveren, H. (author), TNO Kwaliteit van Leven (author)
This report describes the further development of a peanut allergy model in Brown Norway (BN) rats and in particular the importance of allergen-free breeding of the laboratory animals for the allergen to be used. For this purpose BN rats were bred for 3 generations on soy- and peanut-free feed since it is known that the legumes peanut and soy are...
article 2007
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de Jonge, J.D. (author), Ezendam, J. (author), Knippels, L.M.J. (author), Odink, J. (author), Pourier, M.S. (author), Penninks, A.H. (author), Pieters, R. (author), van Loveren, H. (author), TNO Kwaliteit van Leven (author)
Other factors than the allergen itself may be of importance in the development of food allergy. This report describes the influence of the immunosuppressive compound bis(tributyltin)oxide (TBTO), present in the food chain, on the development of food allergy to peanut or ovalbumin in Brown Norway (BN) rats. To study these effects BN rats were...
article 2007
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Kuper, C.F. (author), de Heer, E. (author), van Loveren, H. (author), Vos, J.G. (author), TNO Voeding (author)
bookPart 2002
document
TNO Voeding (author), van Och, F.M.M. (author), Vandebriel, R.J. (author), Prinsen, M.K. (author), de Jong, W.H. (author), Slob, W. (author), van Loveren, H. (author)
[No abstract available]
article 2002
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van Och, F.M.M. (author), Vandebriel, R.J. (author), Prinsen, M.K. (author), de Jong, W.H. (author), Slob, W. (author), van Loveren, H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The guinea pig maximization test (GPMT) has been used as a method for the prediction of skin sensitizing potential for over 30 years. Besides hazard identification, risk assessment of sensitizing chemicals requires the assessment of potency. For the determination of potency based on lowest effective dose levels, dose-response studies are...
article 2001
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van Zijverden, M. (author), de Haar, C. (author), van Beelen, A. (author), van Loveren, H. (author), Penninks, A. (author), Pieters, R. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Some particulate matter is known to affect human health, yet the mechanism(s) by which it acts is largely unknown. One of the factors that may play a role in the immune- stimulating activity of particles is binding of allergen to particles. This may turn the particles into allergen carriers, resulting in antigen deposition within the altered...
article 2001
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van Zijverden, M. (author), van der Pijl, A. (author), Bol, M. (author), van Pinxteren, F.A. (author), de Haar, C. (author), Penninks, A.H. (author), van Loveren, H. (author), Pieters, R. (author)
article 2000
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