Searched for: author:"van Leeuwen, R.T.J."
(1 - 6 of 6)
document
van Leeuwen, R.T.J. (author), Quax, P.H.A. (author), Tippins, J.R. (author), Antoniw, J.W. (author), Andreotti, F. (author), Maseri, A. (author), Kluft, C. (author), Sperti, G. (author), Gaubius Instituut TNO (author)
Background: Lipopolysaccharide (endotoxin) has been shown to increase the expression of plasminogen activator inhibitor type-1 (PAI-1) in the vessel wall. Endotoxin is known to increase PAI-1 production in endothelial cells, but its action on smooth muscle cells (SMCs) is presently not clear. In this study we determined the effect of endotoxin...
article 1996
document
van Leeuwen, R.T.J. (author), Gaubius Laboratory TNO Preventie en Gezondheid (author)
Smooth muscle cells (SMC) form the major cell type in the arterial blood vessels. In the undamaged vessel wall they remain in a contractile state characterized by the absence of cell division, a low metabolic activity and a high actin-myosin content. As a reaction to injury of the vessel wall they can, however, change their phenotype and start...
article 1996
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van Leeuwen, R.T.J. (author), TNO Preventie en Gezondheid (author), PG (author)
doctoral thesis 1996
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van Leeuwen, R.T.J. (author), Kol, A. (author), Andreotti, F. (author), Kluft, C. (author), Maseri, A. (author), Sperti, G. (author), Gaubius Instituut TNO (author)
Background: The role of angiotensin as a vasoconstrictor is well established. Lately, several other actions of this hormone on vascular smooth muscle (VSM) cells have been recognized including the induction of hypertrophy and/or DNA synthesis. Platelet-derived growth factor (PDGF), a mitogen recently shown to increase plasminogen activator...
article 1994
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Weening-Verhoeff, E.J.D. (author), Quax, P.H.A. (author), van Leeuwen, R.T.J. (author), Rehberg, E.F. (author), Marotti, K.R. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)
article 1990
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Quax, P.H.A. (author), van Leeuwen, R.T.J. (author), Verspaget, H.W. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)
In 22 human tumor cell lines the regulation of production of plasminogen activators urokinase (u-PA) and tissue-type (u-PA) and their inhibitors PAI-1 and PAI-2 was studied. These four components may determine the net plasminogen activator activity, which is often associated with tumor development and metastatic processes. The amount of specific...
article 1990
Searched for: author:"van Leeuwen, R.T.J."
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