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Fransman, W. (author), Schinkel, J. (author), Meijster, T. (author), van Hemmen, J. (author), Tielemans, E. (author), Goede, H. (author), TNO Kwaliteit van Leven (author)Objectives: This paper describes the development and evaluation of an evidence database on the effectiveness of risk management measures (RMMs) to control inhalation exposure. This database is referred to as Exposure Control Efficacy Library (ECEL). Methods: A comprehensive review of scientific journals in the occupational hygiene field was...article 2008
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- Kromhout, H. (author), van Wendel-de Joode, B. (author), van Hemmen, J. (author), TNO Kwaliteit van Leven (author) article 2008
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Tielemans, E. (author), Schneider, T. (author), Goede, H. (author), Tischer, M. (author), Warren, N. (author), Kromhout, H. (author), van Tongeren, M. (author), van Hemmen, J. (author), Cherrie, J.W. (author), TNO Kwaliteit van Leven (author)The present paper proposes a source-receptor model to schematically describe inhalation exposure to help understand the complex processes leading to inhalation of hazardous substances. The model considers a stepwise transfer of a contaminant from the source to the receptor. The conceptual model is constructed using three components, i.e. (i) the...article 2008
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- Gerritsen-Ebben, R.M.G. (author), van Hemmen, J. (author), TNO Kwaliteit van Leven (author) article 2007
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Tielemans, E. (author), Warren, N. (author), Schneider, T. (author), Tischer, M. (author), Ritchie, P. (author), Goede, H. (author), Kromhout, H. (author), van Hemmen, J. (author), Cherrie, J.W. (author), TNO Kwaliteit van Leven (author)REACH (Registration, Evaluation and Authorization of CHemicals) requires improved exposure models that can be incorporated into screening tools and refined assessment tools. These are referred to as tier 1 and 2 models, respectively. There are a number of candidate in tier 1 models that could be used with REACH. Tier 2 models, producing robust...article 2007
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Meijster, T. (author), Fransman, W. (author), van Hemmen, J. (author), Kromhout, H. (author), Heederik, D. (author), Tielemans, E. (author), TNO Kwaliteit van Leven (author)Objective: The main goal was to investigate the potential of a probabilistic approach for exposure assessment and use this information to evaluate the impact of a complex of policy actions/interventions on dermal exposure to antineoplastic agents among oncology nurses. The central theme of this study was to make optimal use of existing data,...article 2006
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Pronk, A. (author), Tielemans, E. (author), Skarping, G. (author), Bobeldijk, I. (author), van Hemmen, J. (author), Heederik, D. (author), Preller, L. (author), TNO Kwaliteit van Leven (author)As part of a large-scale epidemiological study, occupational isocyanate exposure was assessed in spray-painting environments. The aim was to assess which compounds contribute to isocyanate exposure in car body repair shops and industrial painting companies, and to identify tasks with high risk of isocyanate exposure. Mainly personal task-based...article 2006
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- Tielemans, E. (author), Heederik, D. (author), Kromhout, H. (author), van Hemmen, J. (author), Meijster, T. (author), Fransman, W. (author), Spaan, S. (author), TNO Voeding (author) article 2004
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van der Jagt, K. (author), Tielemans, E. (author), Links, I. (author), Brouwer, D. (author), van Hemmen, J. (author), TNO Voeding (author)This study assessed the effectiveness of a custom fit personal protective equipment (PPE) program aimed at reducing occupational exposure to pesticides. The intervention study was carried out on 15 pest control operators (PCOs) during mixing/loading and application of chlorpyrifos. Each worker was measured twice; first while the worker used PPE...article 2004
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- van Hemmen, J. (author), TNO Voeding (author) article 2004
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TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author), Tielemans, E. (author), Heederik, D. (author), Kromhout, H. (author), van Hemmen, J. (author), Meijster, T. (author), Fransman, W. (author), Spaan, S. (author)Dit artikel beschrijft een benadering om op branche niveau trends in blootstelling aan chemische en biologische agentia te onderzoeken. Hiervoor is de internationale literatuur over blootstellingstrends geïntentariseerd en beschreven. Hierbij is gebleken dat blootstellingsveranderingen in verschillende industrieën zijn onderzocht. Deze zijn...article 2004
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de Pater, N. (author), Doekes, G. (author), Miedema, E. (author), Goede, H. (author), van Hemmen, J. (author), Heederik, D. (author)Beroepsmatige blootstelling aan meelstof kan leiden tot klachten aan de luchtwegen zoals astma en rhinitis. Deze klachten worden toegeschreven aan de in het stof aanwezige tarwe-allergenen en schimmel alpha-amylase. Het doel van het onderzoek is op basis van de resultaten een taakstelling te formuleren voor een reductie van de blootstelling aan...book 2003
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Tielemans, E. (author), Marquart, H. (author), de Cock, J. (author), Groenewold, M. (author), van Hemmen, J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)There is a growing need for transparency concerning ways in which existing exposure data are weighted for their relative value and quality. Currently, this evaluation is largely subjective and is dependent on the quality of the judgement of the individual assessor or expert group. In this paper some general guidelines are presented for a quality...article 2002
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TNO Voeding (author), Tielemans, E. (author), Christopher, Y. (author), Marquart, H. (author), Groenewold, M. (author), van Hemmen, J. (author)In a recent issue of this journal, Money and Margary (2002) proposed some thoughtful guidelines for exposure assessment in regulatory risk assessment. Their structured approach acknowledges that currently available exposure data are of very variable quality (Northage and Marquart, 2001). We firmly underline their plea for a hierarchy in...article 2002
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Marquart, H. (author), van Drooge, H. (author), Groenewold, M. (author), van Hemmen, J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Exposure assessors involved in regulatory risk assessments often need to estimate a reasonable worst-case full-shift exposure level from very limited exposure information. Full-shift exposure data of very high quality are rare. A full-shift value can also be calculated from (short term) task-based values, either derived from measured data or...article 2001
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Brouwer, D.H. (author), Boeniger, M.F. (author), van Hemmen, J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Hand wash and skin wipes are major techniques that have been used for dermal exposure sampling. Both techniques remove chemicals either deposited on or transferred to the skin contaminant layer by a combination of chemical and mechanical actions. The paper overviews identified methods and techniques, with emphasis on sampling parameters and...article 2000
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- de Pater, N. (author), van Hemmen, J. (author) article 1999
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- Benford, D.J. (author), Cocker, J. (author), Sartorelli, P. (author), Schneider, T. (author), van Hemmen, J. (author), Firth, J.G. (author) article 1999
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Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author), Benford, D.J. (author), Cocker, J. (author), Sartorelli, P. (author), Schneider, T. (author), van Hemmen, J. (author), Firth, J.G. (author)To evaluate risk from dermal exposure, the amount of material on the skin must first be measured. The potential for dermal uptake must then be assessed for the potential health effects from systemic exposure. No standard methods exist for studying these processes, and published data are not comparable because of the different techniques used....article 1999
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- Brouwer, D. (author), van Hemmen, J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author) article 1995
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