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Molema, H. (author), van Erk, M. (author), van Ommen, B. (author), Pijl, H. (author), Wopereis, S. (author), Kiefte-de Jong, J. (author), Chavannes, N. (author), Kremer, B. (author), van Bilsen, J. (author), van Winkelhof, M. (author)Op dit moment is sprake van een COVID-19-pandemie met grote persoonlijke, medische, maatschappelijke en financieel-economische schade. Landen en zorgsystemen gaan tot het uiterste om de COVID-19-uitbraak het hoofd te bieden. In Nederland kunnen we daarbij bouwen op een zeer goed zorgsysteem, zowel in de intensieve zorg (intensive care,...report 2020
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Doets, E.L. (author), de Hoogh, I.M. (author), Holthuysen, N. (author), Wopereis, S. (author), Verain, M.C.D. (author), van den Puttelaar, J. (author), Hogenelst, K. (author), Boorsma, A. (author), Bouwman, E.P. (author), Timmer, M. (author), Pasman, W.J. (author), van Erk, M. (author), Reinders, M.J. (author)The aim of this explorative study is to evaluate whether personalized compared to generic lifestyle advice improves wellbeing in a senior population. We conducted a nine-week single-blind randomized controlled trial including 59 participants (age 67.7 ± 4.8 years) from Wageningen and its surrounding areas in the Netherlands. Three times during...article 2019
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Molema, H. (author), van Erk, M. (author), van Winkelhof, M. (author), van 't Land, K. (author), Kiefte-de Jong, J. (author), van Ommen, B. (author), Pijl, H. (author), Cahn, W. (author), Deenik, J. (author), Maljaars, J. (author), van der Boog, P. (author), van Laarhoven, K. (author), de Reuver, P. (author), van Rossum, L. (author), Hoenders, R. (author), van Schaardenburg, D. (author), Wopereis, S. (author), Bonten, T. (author), Vos, R. (author), Navis, G. (author), Olde Rikkert, M. (author), Kraaijenhagen, R. (author), Preller, L. (author), Stronks, K. (author)Dat leefstijl van groot belang is om gezond te zijn en te blijven, weten de meeste Nederlanders wel. Maar dat leefstijlinterventies effectief ingezet kunnen worden voor herstel of behandeling van ziekten is minder bekend. Daarom richten wij ons bij het Nederlands Innovatiecentrum voor Leefstijlgeneeskunde juist daarop, dat doen we onder de naam...book 2019
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- Kallen, V. (author), Hogenelst, K. (author), Soeter, M. (author), van Erk, M. (author) conference paper 2017
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van Ommen, B. (author), van den Broek, T. (author), de Hoogh, I. (author), van Erk, M. (author), van Someren, E. (author), Rouhani-Rankouhi, T. (author), Anthony, J.C. (author), Hogenelst, K. (author), Pasman, W. (author), Boorsma, A. (author), Wopereis, S. (author)Personalized nutrition is fast becoming a reality due to a number of technological, scientific, and societal developments that complement and extend current public health nutrition recommendations. Personalized nutrition tailors dietary recommendations to specific biological requirements on the basis of a person’s health status and goals. The...article 2017
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Derous, D. (author), Kelder, T. (author), van Schothorst, E.M. (author), van Erk, M. (author), Voigt, A. (author), Klaus, S. (author), Keijer, J. (author), Radonjic, M. (author)Health is influenced by interplay of molecular, physiological and environmental factors. To effectively maintain health and prevent disease, health-relevant relations need to be understood at multiple levels of biological complexity. Network-based methods provide a powerful platform for integration and mining of data and knowledge characterizing...article 2015
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Blaauboer, M.E. (author), Emson, C.L. (author), Verschuren, L. (author), van Erk, M. (author), Turner, S.M. (author), Everts, V. (author), Hanemaaijer, R. (author), Stoop, R. (author)Collagen deposition is a key process during idiopathic pulmonary fibrosis; however, little is known about the dynamics of collagen formation during disease development. Tissue samples of early stages of human disease are not readily available and it is difficult to identify changes in collagen content, since standard collagen analyses do not...article 2013
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Liang, W. (author), Tonini, G. (author), Mulder, P. (author), Kelder, T. (author), van Erk, M. (author), van den Hoek, A.M. (author), Mariman, R. (author), Wielinga, P.Y. (author), Baccini, M. (author), Kooistra, T. (author), Biggeri, A. (author), Kleemann, R. (author)Background:Chronic metabolic overload results in lipid accumulation and subsequent inflammation in white adipose tissue (WAT), often accompanied by non-alcoholic fatty liver disease (NAFLD). In response to metabolic overload, the expression of genes involved in lipid metabolism and inflammatory processes is adapted. However, it still remains...article 2013
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Schoen, E.D. (author), Rubingh, C.M. (author), Wopereis, S. (author), van Erk, M. (author)Background: The False Discovery Rate (FDR) controls the expected number of false positives among the positive test results. It is not straightforward how to conduct a FDR controlling procedure in experiments with a factorial structure, while at the same time there are between-subjects and within-subjects factors. This is because there are P...article 2013
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Wopereis, S. (author), Radonjic, M. (author), Rubingh, C. (author), van Erk, M. (author), Smilde, A. (author), van Duyvenvoorde, W. (author), Cnubben, N. (author), Kooistra, T. (author), van Ommen, B. (author), Kleemann, R. (author)The prevalence of diabetes mellitus Type 2 could be significantly reduced by early identification of subjects at risk, allowing for better prevention and earlier treatment. Glucose intolerance (GI) is a hallmark of the prediabetic stage. This study aims at identifying 1) prognostic biomarkers predicting the risk of developing GI later in life...article 2012
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Mariman, R. (author), Kremer, S.H.A. (author), van Erk, M. (author), Lagerweij, T. (author), Koning, F. (author), Nagelkerken, L. (author)Background: Host-microbiota interactions in the intestinal mucosa play a major role in intestinal immune homeostasis and control the threshold of local inflammation. The aim of this study was to evaluate the efficacy of probiotics in the recurrent trinitrobenzene sulfonic acid (TNBS)-induced colitis model and gain more insight into protective...article 2012
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Kremer, S.H.A. (author), Mariman, R. (author), van Erk, M. (author), Lagerweij, T. (author), Nagelkerken, L. (author)The recurrent TNBS-colitis model in BALB/c mice has been proposed as a model of Inflammatory Bowel Disease with a shifting pattern of local cytokines with the expression of Th1 cytokines during the early phase, Th17 cytokines during the intermediate phase and Th2 cytokines during late fibrotic stages. In this study, we evaluated the development...article 2012
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Kelder, T. (author), Eijssen, L. (author), Kleemann, R. (author), van Erk, M. (author), Kooistra, T. (author), Evelo, C. (author)Background: Complex phenotypes such as insulin resistance involve different biological pathways that may interact and influence each other. Interpretation of related experimental data would be facilitated by identifying relevant pathway interactions in the context of the dataset.Results: We developed an analysis approach to study interactions...article 2011
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Rubio-Aliaga, I. (author), de Roos, B. (author), Sailer, M. (author), McLoughlin, G.A. (author), Boekschoten, M.V. (author), van Erk, M. (author), Bachmair, E.M. (author), van Schothorst, E.M. (author), Keijer, J. (author), Coort, S.L. (author), Evelo, C. (author), Gibney, M.J. (author), Daniel, H. (author), Muller, M. (author), Kleemann, R. (author), Brennan, L. (author)Obesity frequently leads to insulin resistance and the development of hepatic steatosis. to characterize the molecular changes that promote hepatic steatosis, transcriptomics, proteomics, and metabolomics technologies were applied to liver samples from c57bl/6j mice obtained from two independent intervention trials. after 12 wk of high-fat...article 2011
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TNO Kwaliteit van Leven (author), Kleemann, R. (author), van Erk, M. (author), Verschuren, L. (author), van den Hoek, A.M. (author), Koek, M. (author), Wielinga, P.Y. (author), Jie, A. (author), Pellis, L. (author), Bobeldijk-Pastorova, I. (author), Kelder, T. (author), Toet, K. (author), Wopereis, S. (author), Cnubben, N. (author), Evelo, C. (author), van Ommen, B. (author), Kooistra, T. (author)BACKGROUND: The sequence of events leading to the development of insulin resistance (IR) as well as the underlying pathophysiological mechanisms are incompletely understood. As reductionist approaches have been largely unsuccessful in providing an understanding of the pathogenesis of IR, there is a need for an integrative, time-resolved approach...article 2010
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Wheelock, C.E. (author), Wheelock, A.M. (author), Kawashima, S. (author), Diez, D. (author), Kanehisa, M. (author), van Erk, M. (author), Kleemann, R. (author), Haeggström, J.Z. (author), Goto, S. (author), TNO Kwaliteit van Leven (author)Systems biology aims to understand the nonlinear interactions of multiple biomolecular components that characterize a living organism. One important aspect of systems biology approaches is to identify the biological pathways or networks that connect the differing elements of a system, and examine how they evolve with temporal and environmental...article 2009
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TNO Kwaliteit van Leven (author), Verschuren, L. (author), Kooistra, T. (author), Bernhagen, J. (author), Voshol, P. (author), Ouwens, D.M. (author), van Erk, M. (author), de Vries-van der Weij, J. (author), Leng, L. (author), van Bockel, J.H. (author), Willems van Dijkl, K. (author), Fingerle-Rowson, G. (author), Bucala, R. (author), Kleemann, R. (author)Chronic inflammation in white adipose tissue (WAT) is positively associated with obesity, insulin resistance (IR) and the development of type 2 diabetes. The proinflammatory cytokine MIF (macrophage migration inhibitory factor) is an essential, upstream component of the inflammatory cascade. This study examines whether MIF is required for the...article 2009
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- TNO Kwaliteit van Leven (author), Baccini, M. (author), Bachmaier, E.M. (author), Biggeri, A. (author), Boekschoten, M.V. (author), Bouwman, F.G. (author), Brennan, L. (author), Caesar, R. (author), Cinti, S. (author), Coort, S.L. (author), Crosley, K. (author), Daniel, H. (author), Drevon, C.A. (author), Duthie, S. (author), Eijssen, L. (author), Elliott, R.M. (author), van Erk, M. (author), Evelo, C. (author), Gibney, M. (author), Heim, C. (author), Horgan, G.W. (author), Johnson, I.T. (author), Kelder, T. (author), Kleemann, R. (author), Kooistra, T. (author), van Iersel, M.P. (author), Mariman, E.C. (author), Mayer, C. (author), McLoughlin, G. (author), Müller, M. (author), Mulholland, F. (author), van Ommen, B. (author), Polley, A.C. (author), Pujos-Guillot, E. (author), Rubio-Aliaga, I. (author), Roche, H.M. (author), de Roos, B. (author), Sailer, M. (author), Tonini, G. (author), Williams, L.M. (author), de Wit, N. (author) article 2008
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TNO Kwaliteit van Leven (author), Coort, S.L.M. (author), van Iersel, M.P. (author), van Erk, M. (author), Kooistra, T. (author), Kleemann, R. (author), Evelo, C.T.A. (author)Insulin resistance is a characteristic of type-2 diabetes and its development is associated with an increased fat consumption. Muscle is one of the tissues that becomes insulin resistant after high fat (HF) feeding. The aim of the present study is to identify processes involved in the development of HF-induced insulin resistance in muscle of...article 2008
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TNO Kwaliteit van Leven TNO Voeding (author), Garosi, P. (author), de Filippo, C. (author), van Erk, M. (author), Rocca-Serra, P. (author), Sansone, S.A. (author), Elliott, R. (author)Microarrays represent a powerful tool for studies of diet-gene interactions. Their use is, however, associated with a number of technical challenges and potential pitfalls. The cost of microarrays continues to drop but is still comparatively high. This, coupled with the complex logistical issues associated with performing nutritional microarray...article 2005