Searched for: author%3A%22van+Duijn%2C+E.%22
(1 - 15 of 15)
document
Oesterreicher, Z. (author), Eberl, S. (author), Wulkersdorfer, B. (author), Matzneller, P. (author), Eder, C (author), van Duijn, E. (author), Vaes, W.H.J. (author), Reiter, B. (author), Stimpfl, T. (author), Jäger, W. (author), Nussbaumer-Proell, A. (author), Marhofer, D. (author), Marhofer, P. (author), Langer, O. (author), Zeitlinger, M. (author)
Background and Objective In microdose studies, drug pharmacokinetics is measured in humans after administration of subtherapeutic doses. While previous microdose studies focused primarily on plasma pharmacokinetics, we set out to evaluate the feasibility of microdosing for a pharmacokinetic assessment in subcutaneous tissue and epithelial lining...
article 2022
document
Wang, X. (author), Vaes, W.H.J. (author), van Duijn, E. (author), Nooijen, I. (author), Tong, Z. (author), Lopes de Menezes, D. (author), Maxwell, S.E. (author)
We report an accelerator mass spectrometry (AMS) assay to quantify azacitidine (Aza) incorporation into DNA and RNA from human acute myeloid leukemia (AML) cells, mouse bone marrow (BM) and peripheral blood mononuclear cells (PBMCs). Aza, a cytidine nucleoside analogue, is a disease modifying pharmacological agent used for treatment of...
article 2021
document
van Groen, B.D. (author), van Duijn, E. (author), de Vries, A. (author), Mooij, M.G. (author), Tibboel, D. (author), Vaes, W.H.J. (author), de Wildt, S.N. (author)
Growth and development affect drug-metabolizing enzyme activity thus could alter the metabolic profile of a drug. Traditional studies to create metabolite profiles and study the routes of excretion are unethical in children due to the high radioactive burden. To overcome this challenge, we aimed to show the feasibility of an absorption,...
article 2020
document
van Groen, B.D. (author), Vaes, W.H. (author), Park, B.K. (author), Krekels, E.H.J. (author), van Duijn, E. (author), Korgvee, L.T. (author), Maruszak, W. (author), Grynkiewicz, G. (author), Garner, R.C. (author), Knibbe, C.A.J. (author), Tibboel, D. (author), de Wildt, S.N. (author), Turner, M.A. (author)
Aims: Drug disposition in children may vary from adults due to age-related variation in drug metabolism. Microdose studies present an innovation to study pharmacokinetics (PK) in paediatrics; however, they should be used only when the PK is dose linear. We aimed to assess dose linearity of a [14C]midazolam microdose, by comparing the PK of an...
article 2019
document
de Ligt, R. (author), van Duijn, E. (author), Grossouw, D. (author), Bosgra, S. (author), Burggraaf, J. (author), Windhorst, A. (author), Peeters, P.A.M. (author), van der Luijt, G.A. (author), Alexander-White, C. (author), Vaes, W.H.J. (author)
A clinical pharmacokinetic study was performed in 12 healthy women to evaluate systemic exposure to aluminum following topical application of a representative antiperspirant formulation under real-life use conditions. A simple roll-on formulation containing an extremely rare isotope of aluminum (26 Al) chlorohydrate (ACH) was prepared to...
article 2018
document
Swart, P. (author), Lozac'h, F. (author), Simon, M. (author), van Duijn, E. (author), Vaes, W.H. (author)
Modern accelerator mass spectrometry (AMS) methods enable the routine application of this technology in drug development. By the administration of a (14)C-labelled microdose or microtrace, pharmacokinetic (PK) data, such as mass balance, metabolite profiling, and absolute bioavailability (AB) data, can be generated easier, faster, and at lower...
article 2016
document
Vlaming, M.L. (author), van Duijn, E. (author), Dillingh, M.R. (author), Brands, R. (author), Windhorst, A.D. (author), Hendrikse, N.H. (author), Bosgra, S. (author), Burggraaf, J. (author), de Koning, M.C. (author), Fidder, A. (author), Mocking, J.A. (author), Sandman, H. (author), de Ligt, R.A. (author), Fabriek, B.O. (author), Pasman, W.J. (author), Seinen, W. (author), Alves, T. (author), Carrondo, M. (author), Peixoto, C. (author), Peeters, P.A. (author), Vaes, W.H. (author)
Preclinical development of new biological entities (NBEs), such as human protein therapeutics, requires considerable expenditure of time and costs. Poor prediction of pharmacokinetics in humans further reduces net efficiency. In this study, we show for the first time that pharmacokinetic data of NBEs in humans can be successfully obtained early...
article 2015
document
Garner, C.R. (author), Park, K.B. (author), French, N.S. (author), Earnshaw, C. (author), Schipani, A. (author), Selby, A.M. (author), Byrne, L. (author), Siner, S. (author), Crawley, F.P. (author), Vaes, W.H.J. (author), van Duijn, E. (author), de ligt, R. (author), Varendi, H. (author), Lass, J. (author), Grynkiewicz, G. (author), Maruszak, W. (author), Turner, M.A. (author)
Aims The aims of the study were to compare [14C]-paracetamol ([14C]-PARA) paediatric pharmacokinetics (PK) after administration mixed in a therapeutic dose or an isolated microdose and to develop further and validate accelerator mass spectrometry (AMS) bioanalysis in the 0-2 year old age group. Methods [14C]-PARA concentrations in 10-15 μl...
article 2015
document
Bereszczak, J.Z. (author), Havlik, M. (author), Weiss, V.U. (author), Marchetti-Deschmann, M. (author), van Duijn, E. (author), Watts, N.R. (author), Wingfield, P.T. (author), Allmaier, G. (author), Steven, A.C. (author), Heck, A.J.R. (author)
The capsid of hepatitis B virus (HBV) is a major viral antigen and important diagnostic indicator. HBV capsids have prominent protrusions ('spikes') on their surface and are unique in having either T = 3 or T = 4 icosahedral symmetry. Mouse monoclonal and also human polyclonal antibodies bind either near the spike apices (historically the 'α...
article 2014
document
van Duijn, E. (author), Sandman, H. (author), Grossouw, D. (author), Mocking, J.A.J. (author), Coulier, L. (author), Vaes, W.H.J. (author)
The increasing role of accelerator mass spectrometry (AMS) in biomedical research necessitates modernization of the traditional sample handling process. AMS was originally developed and used for carbon dating, therefore focusing on a very high precision but with a comparably low sample throughput. Here, we describe the combination of automated...
article 2014
document
Mooij, M.G. (author), van Duijn, E. (author), Knibbe, C.A.J. (author), Windhorst, A.D. (author), Hendrikse, N.H. (author), Vaes, W.H.J. (author), Spaans, E. (author), Fabriek, B.O. (author), Sandman, H. (author), Grossouw, D. (author), Hanff, L.M. (author), Janssen, P.J.J.M. (author), Koch, B.C.P. (author), Tibboel, D. (author), de Wildt, S.N. (author)
Results: Ten infants (aged 0.1–83.1 months) were included; one was excluded as he vomited shortly after administration. In nine patients, [14C]AAP and metabolites in blood samples were detectable at expected concentrations: median (range) maximum concentration (Cmax) [14C]AAP 1.68 (0.75–4.76) ng/L, [14C]AAP-Glu 0.88 (0.34–1.55) ng/L, and [14C...
article 2014
document
Bereszczak, J.Z. (author), Rose, R.J. (author), van Duijn, E. (author), Watts, N.R. (author), Wingfield, P.T. (author), Steven, A.C. (author), Heck, A.J.R. (author)
Infection of humans by hepatitis B virus (HBV) induces the copious production of antibodies directed against the capsid protein (Cp). A large variety of anticapsid antibodies have been identified that differ in their epitopes. These data, and the status of the capsid as a major clinical antigen, motivate studies to achieve a more detailed...
article 2013
document
Rose, R.J. (author), Thompson, N.J. (author), Van Duijn, E. (author), Damoc, E. (author), Denisov, E. (author), Makarov, A. (author), Heck, A.J.R. (author)
Monoclonal antibodies (mAbs) represent a major class of therapeutic biomolecules being developed by the biopharmaceutical industry, their popularity largely being a result of their high specificity towards targets. Therapeutic mAbs are being developed for various diseases, with a strong focus on cancer and immunological disorders.[1] All...
article 2012
document
Rosati, S. (author), Thompson, N.J. (author), Barendregt, A. (author), Hendriks, L.J. (author), Bakker, A.B. (author), de Kruif, J. (author), Throsby, M. (author), van Duijn, E. (author), Heck, A.J. (author)
Native mass spectrometry was evaluated for the qualitative and semiquantitative analysis of composite mixtures of antibodies representing biopharmaceutical products coexpressed from single cells. We show that by using automated peak fitting of the ion signals in the native mass spectra, we can quantify the relative abundance of each of the...
article 2012
document
van Duijn, E. (author), Barbu, I.M. (author), Barendregt, A. (author), Jore, M.M. (author), Wiedenheft, B. (author), Lundgren, M. (author), Westra, E.R. (author), Brouns, S.J.J. (author), Doudna, J.A. (author), van der Oost, J. (author), Heck, A.J.R. (author)
The CRISPR/Cas (clustered regularly interspaced short palindromic repeats/CRISPR-associated genes) immune system of bacteria and archaea provides acquired resistance against viruses and plasmids, by a strategy analogous to RNA-interference. Key components of the defense system are ribonucleoprotein complexes, the composition of which appears...
article 2012
Searched for: author%3A%22van+Duijn%2C+E.%22
(1 - 15 of 15)