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Hennis, B.C. (author), Boomsma, D.I. (author), van Boheemen, P.A. (author), Engesser, L. (author), Kievit, P. (author), Dooijewaard, G. (author), Kluft, C. (author), TNO Preventie en Gezondheid (author)A pedigree-based maximum likelihood method developed by Lange et al. (12) was used to study the contribution of a newly defined di-allelic polymorphism in histidine-rich glycoprotein (HRG) to the plasma levels of HRG. In four families (n = 99) and 20 volunteers we found a heritability of 70%, an age effect of 3% and an effect of individual...article 1995
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Hennis, B.C. (author), van Boheemen, P.A. (author), Wakabayashi, S. (author), Koide, T. (author), Hoffmann, J.J.M.L. (author), Kievit, P. (author), Dooijewaard, G. (author), Jansen, J.G. (author), Klutf, C. (author), TNO Preventie en Gezondheid (author)Two forms of histidine-rich glycoprotein (HRG) were detected on SDS-PAGE by silver staining and immunoblotting after isolation of the protein from pooled plasma using immune-affinity chromatography followed by chromatography with heparin-Sepharose. Both forms were single-chain molecules and the apparent molecular weights of form 1 and form 2...article 1995
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van Boheemen, P.A. (author), van den Hoogen, N.M. (author), Koolwijk, N. (author), Instituut voor Verouderings- en Vaatziekten Onderzoek TNO (author)Six murine monoclonal antibodies (MAbs) specific for urokinase-type plasminogen activator (u-PA) were tested for their ability to inhibit u-PA activity in three different assays with respect to amidolytic activity, plasminogen activation and fibrinolytic activity. Two of the MAbs were able to inhibit the amidolytic activity of u-PA. One MAb (LMW...article 1995
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Hennis, B.C. (author), van Boheemen, P.A. (author), Koeleman, B.P.C. (author), Boomsma, D.I. (author), Engesser, L. (author), van Wees, A.G.M. (author), Novakova, I. (author), Brommer, E.J.P. (author), Kluft, C. (author), Gaubius Instituut TNO (author)Recent studies describe families with both elevated plasma HRG levels and thrombosis. In order to study the possibility that allelic variants of the HRG locus are associated with differences in HRG level, we studied linkage between HRG levels and a dinucleotide repeat polymorphism in a Dutch family which was selected on the presence of both...article 1995
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Dooijewaard, G. (author), van Boheemen, P.A. (author), Binnema, D.J. (author), Kluft, C. (author), Gaubius Laboratory, VVO-TNO, PO Box 430, 2300 AK Leiden, Instituut voor verouderings- en vaatziekten onderzoek TNO (author)Chemicals/CAS: Tissue Plasminogen Activator, EC 3.4.21.68; Urinary Plasminogen Activator, EC 3.4.21.73article 1992