The effect of age on the biliary excretion of digitoxin and its metabolites in female BN/Bi rats

The biliary excretion of digitoxin (Dt3) and its metabolites was studied in female BN/Bi rats of different ages ranging from 3 to 30 mth. The disappearance of radioactivity from plasma after an i.v. injection of [3H]Dt3 (0.01 mg/100 g body weight) gradually slowed as rat age advanced. The 2-h biliary recovery of radioactivity (percent of the...