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- te Koppele, J.M. (author), Lucassen, P.J. (author), Sakkee, A.N. (author), van Asten, J.G. (author), Ravid, R. (author), Swaab, D.F. (author), van Bezooijen, C.F.A. (author), Gaubius Instituut TNO (author) article 1996
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- van Bezooijen, C.F.A. (author) bookPart 1994
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Groen, K. (author), Breimer, D.D. (author), Jansen, E.J. (author), van Bezooijen, C.F.A. (author), Gaubius Instituut TNO (author)The influence of aging on the metabolism of antipyrine (AP) and hexobarbital enantiomers (R-HB and S-HB) with and without phenobarbital (PB) induction was investigated in a longitudinal study in rats aged 6, 12, 24 and 30 months. The metabolic clearances of AP (Cl(m AP)), R-HB (Cl(m R-HB)) and S-HB (Cl(m S-HB)) were used as indicators for P450...article 1994
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Instituut voor Verouderings- en Vaatziekten Onderzoek TNO (author), Horbach, G.J.M.J. (author), van Asten, J.G. (author), Rietjens, I.M.C.M. (author), Kremers, P. (author), van Bezooijen, C.F.A. (author)The content and specific activities of inducible cytochrome P-450 enzymes were determined in liver microscomes of rats of various ages after maximal induction with phenobarbital, isosafrole of 3-methylcholanthrene, and in untreated animals. With age an increase in liver weight was observed both in untreated rats and in maximally induced ones;...article 1992
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- Cornet, M. (author), Callaerts, A. (author), Segaert, A. (author), van Bezooijen, C.F.A. (author), Vercruysse, A. (author), Rogiers, V. (author), Instituut voor verouderings- en vaatziekten onderzoek TNO (author) bookPart 1991
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- Groen, K. (author), Brouwer, E.J. (author), Jansen, E.J. (author), Schijff, G. (author), Breimer, D.D. (author), van Bezooijen, C.F.A. (author), Instituut voor Verouderings- en Vaatziekten Onderzoek TNO (author) bookPart 1991
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- te Koppele, J.M. (author), Groen, K. (author), Stijnen, A.M. (author), Horbach, G.J.M.J. (author), Horan, M.A. (author), Jansen, E.J. (author), Danhof, M. (author), Breimer, D.D. (author), van Bezooijen, C.F.A. (author), TNO Preventie en Gezondheid (author) bookPart 1991
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Instituut voor experimentele gerontologie TNO (author), Boonstra-Nieveld, I.H.J. (author), van Bezooijen, C.F.A. (author)Hexobarbital is a drug widely used to study the capacity of the liver to metabolize drugs. The pharmacokinetics of hexobarbital in 3- and 30-month-old male BN/BiRij rats were studied. The half-life of hexobarbital in 30-month-old rats (34.9 ± 4.1 min) was significantly higher than that of 3-month-old ones (21.3 ± 3.8 min). The volume of...article 1989
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Horbach, G.J.M.J. (author), Princen, H.M.G. (author), van der Kroef, M. (author), van Bezooijen, C.F.A. (author), Yap, S.H. (author)To investigate the regulation of age-related changes in albumin synthesis in the rat liver, total postnuclear RNA and polyribosomes, both membrane-bound and free, were prepared from livers of rats of different ages. By the use of a specific complementary DNA probe, the albumin mRNA sequence content was quantitated in these RNA fractions. These...article 1984
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Instituut voor experimentele gerontologie TNO (author), Horbach, G.J.M.J. (author), Yap, S.H. (author), van Bezooijen, C.F.A. (author)Albumin elimination rates were determined in 3-, 12-, 24- and 36-month-old female WAG/Rij rats. No change in elimination half-life was found with age. However, as there was an increase in the whole-body albumin pool, a concomitant increase in albumin clearance was observed at between 12 and 36 months of age. It was concluded that the increase in...article 1983
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Instituut voor experimentele gerontologie TNO (author), van Bezooijen, C.F.A. (author), Sakkee, A.N. (author), Knook, D.L. (author)Protein-synthesizing activity was studied in hepatocytes isolated from rats of various ages with or without treatment with 80 mg meclofenoxate/day per kg body weight for 2 weeks. The substance did not influence protein synthesis in hepatocytes isolated from 3- and 12-month-old rats, but drastically decreased the synthesis of protein by...article 1983
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- Gezondheidsorganisatie TNO Instituut voor experimentele gerontologie TNO (author), van Bezooijen, C.F.A. (author) doctoral thesis 1978