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Kaman, W.E. (author), Voskamp-Visser, I. (author), de Jongh, D.M.C. (author), Endtz, H.P. (author), van Belkum, A. (author), Hays, J.P. (author), Bikker, F.J. (author)Bacterial proteases play an important role in a broad spectrum of processes, including colonization, proliferation, and virulence. In this respect, bacterial proteases are potential biomarkers for bacterial diagnosis and targets for novel therapeutic protease inhibitors. To investigate these potential functions, the authors designed and used a...article 2013
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Manenschijn, L. (author), Jetten, A.M. (author), van Wamel, W.J.B. (author), Tavakol, M. (author), Koper, J.W. (author), van den Akker, E.L.T. (author), van Belkum, A. (author), van Rossum, E.F.C. (author)Staphylococcus aureus (S. aureus) colonizes the anterior nares in part of the population and the persistent carrier state is associated with increased infection risk. Knowledge concerning the determinants of S. aureus nasal carriage is limited. Previously, we found that glucocorticoid receptor polymorphisms influence carrier risk, suggesting...article 2012
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Kaman, W.E. (author), Hulst, A.G. (author), van Alphen, P.T.W. (author), Roffel, S. (author), van der Schans, M.J. (author), Merkel, T. (author), van Belkum, A. (author), Bikker, F.J. (author)We describe the development of a highly specific enzyme-based fluorescence resonance energy transfer (FRET) assay for easy and rapid detection both in vitro and in vivo of Bacillus spp., among which are the members of the B. cereus group. Synthetic substrates for B. anthracis proteases were designed and exposed to secreted enzymes of a broad...article 2011
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Duim, B. (author), Godschalk, P.C.R. (author), van den Braak, N. (author), Dingle, K.E. (author), Dijkstra, J.R. (author), Leyde, E. (author), van der Plas, J. (author), Colles, F.M. (author), Endtz, H.P. (author), Wagenaar, J.A. (author), Maiden, M.C.J. (author), van Belkum, A. (author)Campylobacter jejuni isolates (n = 234) associated with gastroenteritis and the Guillain-Barré syndrome (GBS) in the island of Curaçao, Netherlands Antilles, and collected from March 1999 to March 2000 were investigated by a range of molecular typing techniques. Data obtained by pulsed-field gel electrophoresis (PFGE), amplified fragment length...article 2003
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Verduin, C.M. (author), Kools-Sijmons, M. (author), van der Plas, J. (author), Vlooswijk, J. (author), Tromp, M. (author), van Dijk, H. (author), Banks, J. (author), verbrugh, H. (author), van Belkum, A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Moraxella catarrhalis is a bacterial species that has been implicated in 15^20% of all cases of otitis media in the USA and the complementresistantvariant of M. catarrhalis has been considered particularly pathogenic. A collection of geographically diverse, complement-sensitive (n = 28) and -resistant strains (n = 47) of M. catarrhalis was...article 2000