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Instituut voor verouderings- en vaatziekten onderzoek TNO (author), HogenEsch, H. (author), Gijbels, M.J.J. (author), Offerman, E. (author), van Hooft, J. (author), van Bekkum, D.W. (author), Zurcher, C. (author)Chronic proliferative dermatitis is a new spontaneous mutation in C57BL/Ka mice. Breeding results suggest an autosomal recessive mode of inheritance. Mutant mice develop skin lesions at the age of 5 to 6 weeks. The lesions occur in the ventral and dorsal skin of the body, whereas ears, footpads, and tail are not involved. The lesions are...article 1993
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Instituut voor Toegepaste Radiobiologie en Immunologie TNO (author), van Beusechem, V.W. (author), Kukler, A. (author), Einerhand, M.P.W. (author), Bakx, T.A. (author), van der Eb, A.J. (author), van Bekkum, D.W. (author), Valerio, D. (author)Amphotropic recombinant retroviruses were generated carrying sequences encoding human adenosine deaminase (ADA). Transcription of the human ADA gene was under control of a hybrid long terminal repeat in which the enhancer from the Moloney murine leukemia virus was replaced by an enhancer from the F101 host-range mutant of polyoma virus....article 1990
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Champlin, R.E. (author), Horowitz, M.M. (author), van Bekkum, D.W. (author), Camitta, B.M. (author), Elfenbein, G.E. (author), Gale, R.P. (author), Gluckman, E. (author), Good, R.A. (author), Rimm, A.A. (author), Rozman, C. (author), Speck, B. (author), Bortin, M.M. (author), Gaubius Instituut TNO (author)Graft failure was analyzed in 625 patients receiving allogeneic bone marrow transplants from HLA-identical sibling donors as treatment for severe aplastic anemia. Sixty-eight (11%) had no or only transient engraftment. Second bone marrow transplants were successful in achieving extended survival in 16 of 27 patients with transient initial...article 1989
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- Radiobiologisch instituut TNO (author), van Bekkum, D.W. (author), Barendsen, G.W. (author), Broerse, J.J. (author) book 1986
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- van Bekkum, D.W. (author), Prins, M.E.F. (author), Hagenbeek, A. (author), Radiobiologisch instituut TNO (author) article 1981
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Radiobiologisch Instituut TNO (author), Sonneveld, P. (author), van Bekkum, D.W. (author)Adriamycin (ADR) accumulates in well-perfused organs in the rat. This effect is especially evident for long periods in marrow and spleen of healthy animals. In rats bearing the Brown Norway Acute Myeloid Leukaemia (BNML) the in vitro distribution is significantly different. Maximum ADR levels in those organs which are morphologically infiltrated...article 1981
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- van Bekkum, D.W. (author), Radiobiologisch Instituut TNO (author) bookPart 1980
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van Bekkum, D.W. (author), van den Engh, G.J. (author), Wagemaker, G. (author), Radiobiologisch Instituut TNO (author)A review is presented of the experiments that resulted in the identification of a specific morphologic entity representing the pluripotential hemopoietic stem cell (HSC) in mouse bone marrow. This entity was subsequently discovered in concentrated HSC preparations from bone marrow of rats, monkeys, and humans. In the mouse, a set of physical...article 1979
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van Bekkum, D.W. (author), Radiobiologisch instituut TNO (author)Mammography for mass screening - A critical discussion is presented of the new directives regarding the use of mammography for mass screening issued by the National Cancer Institute in the U.S.A. The considerations are explained on the basis of which these directives advise against mammography for screening of women younger than 50 years. There...article 1978
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van Bekkum, D.W. (author), Hagenbeek, A. (author), Radiobiologisch Instituut TNO (author)The transplantable promyelocytic leukemia in BN rat (BNML) is a relatively slow-growing leukemia which has many characteristics in common with human acute myeloid leukemia (AML). As compared with normal myeloid cells, the leukemic cells have a prolonged transit time in the peripheral blood, a low growth fraction and high cell loss in the spleen...article 1977
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- Dicke, K.A. (author), Schaefer, U.W. (author), van Bekkum, D.W. (author), Radiobiologisch Instituut TNO (author) conference paper 1974
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Ormai, S. (author), Hagenbeek, A. (author), Palkovits, M. (author), van Bekkum, D.W. (author), Radiobiologisch Instituut TNO (author)The changes in lymphocyte kinetics induced by the lymphocyte mobilizing agent polymethacrylic acid (PMAA) were studied in the normal rat. Quantitative data are presented concerning the degree of lymphocyte mobilization in the spleen and in various lymph nodes at different times after PMAA administration. Data were also obtained regarding the...article 1973
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- van Bekkum, D.W. (author), Radiobiologisch instituut TNO (author) article 1973
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van Bekkum, D.W. (author), Balner, H. (author), Dicke, K.A. (author), van den Berg, F.G. (author), Prinsen, G.H. (author), Hollander, C.F. (author), Radiobiologisch Instituut TNO (author)Short-term pretreatment of irradiated, bone marrow-treated monkeys with horse antilymphocyte serum (ALS) roughly doubles the survival time by decreasing the severity and delaying the onset of acute secondary disease in random host-donor combinations. It was found that (1) horse anti monkey serum does not interfere with the take and proliferation...article 1972
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Dicke, K.A. (author), Platenburg, M.G.C. (author), van Bekkum, D.W. (author), Radiobiologisch Instituut TNO (author)Using a method in which embryo fibroblasts were used as feeder layers, the colony forming capacity in agar of a variety of mouse haemopoietic suspensions was compared with their CFUs content. A striking parallelism between the results of the two assays was found. In addition, under certain conditions higher numbers of CFUs could be retrieved...article 1971
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- Dooren, L.J. (author), de Koning, J. (author), van Bekkum, D.W. (author), Radiobiologisch instituut TNO (author) article 1970
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- van Bekkum, D.W. (author), Radiobiologisch instituut TNO (author) article 1970
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- van Bekkum, D.W. (author), Radiobiologisch instituut TNO (author) article 1969
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- Gezondheidsorganisatie TNO Radiobiologisch Instituut TNO (author), van Putten, L.M. (author), van Bekkum, D.W. (author), de Vries, M.J. (author) bookPart 1968
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- Radiobiological Institute TNO (author), van Bekkum, D.W. (author), de Vries, M.J. (author), van der Waay, D. (author) article 1968