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TNO Preventie en Gezondheid (author), van Dijk, K.W. (author), van Vlijmen, B.J.M. (author), van 't Hof, H.B. (author), van der Zee, A. (author), Santamarina-Fojo, S. (author), van Berkel, T.J.C. (author), Havekes, L.M. (author), Hofker, M.H. (author)
To investigate the quantitative requirement for apolipoprotein (apo) E in the clearance of lipoproteins via the non-low density lipoprotein (LDL) receptor mediated pathway, human APOE was overexpressed at various levels in the livers of mice deficient for both the endogenous Apoe and Ldlr genes (Apoe-/- ยท Ldlr-/-) using adenovirus-mediated gene...
article 1999
Gaubius Instituut TNO (author), van Vlijmen, B.J.M. (author), Mensink, R.P. (author), van 't Hof, H.B. (author), Offermans, R.F.G. (author), Hofker, M.H. (author), Havekes, L.M. (author)
Studying the effects of dietary fish oil on VLDL metabolism in humans is subject to both large intra- and interindividual variability. In the present study we therefore used hyperlipidentic apolipoprotein (APO) E*3-Leiden mice, which have impaired chylomicron and very low density lipoprotein (VDL) remnant metabolism, to study the effects of...
article 1998
Gaubius Instituut TNO (author), van Vlijmen, B.J.M. (author), van Dijk, K.W. (author), van 't Hof, H.B. (author), van Gorp, P.J.J. (author), van der Zee, A. (author), van der Boom, H. (author), Breuer, M.L. (author), Hofker, M.H. (author), Havekesf, L.M. (author)
Apolipoprotein E*2(Arg-155 โ†’ Cys) (APOE*2) transgenic mice were generated and compared to the previously generated apolipoprotein E*3- Leiden (APOE*3-Leiden) transgenic mice to study the variable expression of hyperlipoproteinemia associated with these two APOE variants. In the presence of the endogenous mouse Apoe gene, the expression of the...
article 1996