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Identification of disease- and nutrient-related metabolic fingerprints in osteoarthritic guinea pigs

Lamers, R.-J.A.N. (author), de Groot, J. (author), Spies-Faber, E.J. (author), Jellema, R.H. (author), Kraus, V.B. (author), Verzijl, N. (author), te Koppele, J.M. (author), Spijksma, G.K. (author), Vogels, J.T.W.E. (author), van der Greef, J. (author), van Nesselrooij, J.H.J. (author)

Osteoarthritis (OA), one of the most common diseases among the elderly, is characterized by the progressive destruction of joint tissues. Its etiology is largely unclear and no effective disease-modifying treatment is currently available. Metabolic fingerprinting provides a novel tool for the identification of biomarkers. A metabolic fingerprint...

article 2003

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Changes in Water Content, Collagen Degradation, Collagen Content, and Concentration in Repeated Biopsies of the Cervix of Pregnant Cows

Breeveld-Dwarkasing, V.N.A. (author), te Koppele, J.M. (author), Bank, R.A. (author), van der Weijden, G.C. (author), Taverne, M.A.M. (author), Dissel van - Emiliani, F.M.F. (author), Gaubius Instituut TNO (author)

The objective of the present study was to assess if cervical ripeness could be quantified by measuring the percentage of denaturation of the collagen network of the stromal layer. Biopsy specimens from the caudal part of the cervix were obtained from nine pluriparous cows between Days 149 and 157 of gestation (second-trimester biopsy), at...

article 2003

document

Identification of PLOD2 as Telopeptide Lysyl Hydroxylase, an Important Enzyme in Fibrosis

TNO Preventie en Gezondheid (author), van der Slot, A.J. (author), Zuurmond, A.M. (author), Bardoel, A.F.J. (author), Wijmenga, C. (author), Pruijs, H.E.H. (author), Sillence, D.O. (author), Brinckmann, J. (author), Abraham, D.J. (author), Black, C.M. (author), Verzijl, N. (author), de Groot, J. (author), Hanemaaijer, R. (author), te Koppele, J.M. (author), Huizinga, T.W.J. (author), Bank, R.A. (author)

The hallmark of fibrotic processes is an excessive accumulation of collagen. The deposited collagen shows an increase in pyridinoline cross-links, which are derived from hydroxylated lysine residues within the telopeptides. This change in cross-linking is related to irreversible accumulation of collagen in fibrotic tissues. The increase in...

article 2003

document

Bone turnover, joint damage and bone mineral density in early rheumatoid arthritis treated with combination therapy including high-dose prednisolone

Verhoeven, A.C. (author), Boers, M. (author), te Koppele, J.M. (author), van der Laan, W.H. (author), Markusse, H.M. (author), Geusens, P. (author), van der Linden, S. (author), Gaubius Instituut (author)

Objectives. Exploration of bone metabolism changes at different levels of disease activity, both with and without oral corticosteroid therapy, and prediction of changes in joint damage and bone density from the observed changes in markers of bone turnover. Methods. Data analysis from a randomized clinical trial with 155 rheumatoid arthritis (RA)...

article 2001

document

Lack of effect of doxyxyxline on disease activity and pyridinoline excretion rates in rheumatoid arthritis: a double-blind placebo-controlled study: abstract

Gaubius Instituut TNO (author), van der Laan, W.H. (author), Molenaar, E.T. (author), Verheijen, J.H. (author), Breedveld, F.C. (author), Dijkmans, B.A.C. (author), te Koppele, J.M. (author)

article 2000

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Increase in the advanced glycation end product pentosidine in Bruch's membrane with age

Handa, J.T. (author), Verzijl, N. (author), Matsunaga, H. (author), Aotaki-Keen, A. (author), Lutty, G.A. (author), te Koppele, J.M. (author), Miyata, T. (author), Hjelmeland, L.M. (author)

PURPOSE. To determine whether there is an age-related increase of pentosidine in human Bruch's membranes and to localize pentosidine and carboxymethyllysine (CML), two well-characterized, advanced glycation end products (AGEs) in aged human Bruch's membranes and choroid in vivo. METHODS. Human Bruch's membrane samples were isolated from the...

article 1999

document

Proteolytic degradation of the collagen network results in cartilage with inferior biomechanical properties

Bank, R.A. (author), te Koppele, J.M. (author)

Swelling of cartilage, one of the early signs of osteoarthritis (OA), is considered to be the result of a collagen network that has lost its integrity. So far, no quantitative data directly support this assertion: combined measurements of the state of the collagen network per se and the degree of swelling are lacking. Degraded collagen molecules...

article 1999

document

Synthesis of reduced collagen crosslinks

van den Nieuwendijk, A.M.C.H. (author), Benningshof, J.C.J. (author), Wegmann, V. (author), Bank, R.A. (author), te Koppele, J.M. (author), Brussee, J. (author), van der Gen, A. (author), TNO Preventie en Gezondheid (author)

A new synthetic route to reduced collagen crosslinks (LNL and HLNL) is described in this report. It enables an enantioselective synthesis of LNL. HLNL was obtained as a mixture of two diastereoisomers. This method also provides the possibility to introduce radio-labels during the synthesis.

article 1999

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Degradation of a cartilage-like matrix by rheumatoid synovial fibroblasts is inhibited by gene transfer with a cell surface-targeted plasmin inhibitor: abstract

Gaubius Instituut TNO (author), van der Laan, W.H. (author), Ronday, H.K. (author), Grimbergen, J.M. (author), Huisman, L.G.M. (author), Breedveld, F.C. (author), te Koppele, J.M. (author), Huizinga, T.W.J. (author), Quax, P.H.A. (author), Verheijen, J.H. (author)

article 1999

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Hyperglycemia, hyperinsulinemia and inflammation in type II diabetics are associated with specific deviations in haemostatic variables: abstract

Gaubius Instituut TNO (author), Kluft, C. (author), Meijer, P. (author), Gram, J. (author), Jespersen, J. (author), Sidelmann, J. (author), te Koppele, J.M. (author), Buytenhek, M. (author)

conference paper 1999

document

A novel pyrroleninone cross-link from bovine dentine

Kleter, G.A. (author), Damen, J.J.M. (author), van den Kettenes-Bosch, J.J. (author), Bank, R.A. (author), te Koppele, J.M. (author), Veraart, J.R. (author), ten Cate, J.M. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)

The aim was to identify suspect collagen cross-links in dentine, eluting close to known cross-links in ion-exchange HPLC. Bovine tooth roots as source of dentine were powdered, demineralised, reduced, and acid-hydrolysed. Cross-linking amino acids were isolated from the acid hydrolysate by size exclusion, adsorption, and sequential ion exchange...

article 1998

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Hydrogen atom abstraction of 3,5-disubstituted analogues of paracetamol by horseradish peroxidase and cytochrome P450

Bessems, J.G.M. (author), de Groot, M.J. (author), Baede, E.J. (author), te Koppele, J.M. (author), Vermeulen, N.P.E. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

1. The formation of free radicals during enzyme catalysed oxidation of eight 3,5-disubstituted analogues of paracetamol (PAR) has been studied. A simple peroxidase system as well as cytochrome P450-containing systems were used. Radicals were detected by electron spin resonance (ESR) on incubation of PAR and 3,5-diCH3-, 3,5-diC2H5-, 3,5-ditC4H9-,...

article 1998

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Amino acid analysis by reverse-phase high-performance liquid chromatography: Improved derivatization and detection conditions with 9-fluorenylmethyl chloroformate

Bank, R.A. (author), Jansen, E.J. (author), Beekman, B. (author), te Koppele, J.M. (author), Gaubius Instituut TNO (author)

article 1996

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Rat liver microsomal cytochrome P450-dependent oxidation of 3,5-disubstituted analogues of paracetamol

Bessems, J.G.M. (author), te Koppele, J.M. (author), van Dijk, P.A. (author), van Stee, L.L.P. (author), Commandeur, J.N.M. (author), Vermeulen, N.P.E. (author), Leiden/Amsterdam Ctr. for Drug Res., Division of Molecular Toxicology, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, Netherlands Dept. Vasc. Connective Tissue Res TNO Preventie en Gezondheid (author)

1. The cytochrome P450-dependent binding of paracetamol and a series of 3,5-disubstituted paracetamol analogues (R = -F, -Cl, -Br, -I, -C(H)3, -C2H5, -iC3H7) have been determined with β-naphthoflavone (βNF)-induced rat liver microsomes and produced reverse type I spectral changes. K(s,app) varied from 0.14 mM for 3,5-diiC3H7-paracetamol to 2.8...

article 1996

document

Enzyme kinetics and substrate selectivities of rat glutathione S-transferase isoenzymes towards a series of new 2-substituted 1-chloro-4-nitrobenzenes

van der Aar, E.M. (author), Buikema, D. (author), Commandeur, J.N.M. (author), te Koppele, J.M. (author), van Ommen, B. (author), van Bladeren, P.J. (author), Vermeulen, N.P.E. (author), Leiden/Amsterdam Ctr. for Drug Res., Department of Pharmacochemistry, Vrije Universiteit, De Boelelaan 1083, 1081 HV, Amsterdam, Netherlands TNO Preventie en Gezondheid TNO Voeding (author)

1. Four different rat glutathione S-transferase (GST) isoenzymes, belonging to three different classes, were examined for their GSH conjugating capacity towards 11 2-substituted 1-chloro-4-nitrobenzene derivatives. Significant differences were found in their enzyme kinetic parameters K(m), k(cat) and k(cat)/K(m). 2. Substrates with bulky...

article 1996

document

Effect of IGF1 and TGFß2 on assembly of proteoglycans and collagen by cultured bovine articular chondrocytes

van Osch, G.J.V.M. (author), van den Berg, W.B. (author), te Koppele, J.M. (author), van der Kraan, P.M. (author), Beekman, B. (author), Homminga, G.N. (author), Häuselmann, H.J. (author), TNO Preventie en Gezondheid (author)

conference paper 1996

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Cleavage of collagen type I and II telopeptides by stromelysin is limited to the N-terminal telopeptide of collagen type II

Böhm, B.B. (author), Beekman, B. (author), Drijfhout, J.W. (author), te Koppele, J.M. (author), Gaubius Instituut TNO (author)

conference paper 1996

document

8OHdG levels in brain do not indicate oxidative DNA damage in Alzheimer's disease

te Koppele, J.M. (author), Lucassen, P.J. (author), Sakkee, A.N. (author), van Asten, J.G. (author), Ravid, R. (author), Swaab, D.F. (author), van Bezooijen, C.F.A. (author), Gaubius Instituut TNO (author)

article 1996

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Ageing and osteoarthritis: Age-related changes in collagen of articular cartilage;

te Koppele, J.M. (author), Bank, R.A. (author), Bayliss, M.T. (author), Gaubius Instituut TNO (author)

Osteoarthritis (OA) is a multifac{orial chronic disease with high incidence and prevalence in the elderly. Age is a major risk facto/ in the occurrence ol OA. ln the populat¡on, few individuals suffer from 'early onset OA'. The maiority of individuals have 'late onset OA', whereas a minority of elderly lacks OA. Such a profile is comparable to...

conference paper 1995

document

Assessment of joint degradation in collagen-induced arthritis in rhesus monkeys (abstract)

te Koppele, J.M. (author), TNO Preventie en Gezondheid (author)

article 1995