Searched for: author:"de Vries, R.E.M."
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van den Eijnden-Schrauwen, Y. (author), Atsma, D.E. (author), Lupu, F. (author), de Vries, R.E.M. (author), Kooistra, T. (author), Emeis, J.J. (author), TNO Preventie en Gezondheid (author)
In this study, we investigated the role of Ca2+ and G proteins in thrombin-induced acute release (regulated secretion) of tissue-type plasminogen activator (TPA) and yon Willebrand factor (vWF), using a previously described system of primary human umbilical vein endothelial cells (HUVECs). The acute release of TPA and vWF, as induced by α...
article 1997
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van den Eijnden-Schrauwen, Y. (author), Kooistra, T. (author), de Vries, R.E.M. (author), Emeis, J.J. (author), Gaubius Instituut TNO (author)
The process of acute release of tissue-type plasminogen activator (tPA) is important in locally speeding up fibrinolysis. Using a sensitive enzyme- linked immunosorbent assay for tPA, we investigated the acute release of tPA from cultured human umbilical vein endothelial cells. The addition of thrombin (0.003 to 3 NIH U/mL) caused the dose...
article 1995
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Schrauwen, Y. (author), de Vries, R.E.M. (author), Kooistra, T. (author), Emeis, J.J. (author), TNO Preventie en Gezondheid (author)
The acute release of t-PA was studied in vitro in human endothelial cells from different origin. It proved possible to enhance the amounts of t-PA which can be released by increasing t-PA synthesis, both in vitro, and in vivo in rats. These data suggest the feasibility to induce and (or) enhance acute release of t-PA in man. Chemicals/CAS:...
article 1994