Development and characterisation of an in vitro photomicronucleus test using ex vivo human skin tissue

Photosafety testing is of concern for the evaluation of personal care products and pharmaceuticals. Current regulatory guidance state that photosafety should be evaluated for compounds that absorb radiation between 290 and 700 nm with relevant exposure in the skin or eyes. However, oversensitivity and the occurrence of 'pseudo-effects' with...

Evaluation of the in vivo genetic toxicity of concentrated barley β-glucan

Chemicals / CAS: corn oil, 8001-30-7; mitomycin C, 50-07-7, 74349-48-7; Glucans; Mutagens

Safety evaluation of an α-cyclodextrin glycosyltranferase preparation

Alpha-cyclodextrin glucosyltransferase (α-CGTase, EC 2.4.1.19) is an amylolytic enzyme used for the production of α-cyclodextrin (α-CD), a novel, soluble dietary fiber, from food-grade starch. The safety of an α-CGTase preparation obtained by batch fermentation from a recombinant strain of Escherichia coli K12 harboring the α-CGTase gene from...

Lack of clastogenic effects in cultured human lymphocytes treated with hydroquinone

Hydroquinone (HQ) occurs in the environment as a result of manmade processes as well as in natural products from plants and animals. The compound has been reported to produce chromosomal effects in some in vivo and in vitro animal models. However, its potential to produce similar effects in human lymphocytes is less clear. To obtain more...

Biological monitoring the exposure to polycyclic aromatic hydrocarbons of coke oven workers in relation to smoking and genetic polymorphisms for GSTM1 GSTT1

Occupational exposure to polycyclic aromatic hydrocarbons (PAH) increases the risk of developing lung cancer. Human exposure is often demonstrated by increased internal levels of PAH metabolites and of markers for early biological effects, like DNA adducts and cytogenetic aberrations. Objective: This study aimed to assess whether the current...

Genotoxicity evaluation of wood-derived and vegetable oil-derived stanol esters

Genotoxicity evaluation of wood-derived and vegetable oil-derived stanol esters

Plant stanol esters from wood and vegetable oil sources were tested for genotoxicity in bacterial (Salmonella typhimurium) and mammalian cell (L5178Y) gene mutation assays and in a mammalian cell chromosome aberration assay (CHO cells). The two stanol ester formulations were tested separately at doses up to the limit of solubility, with and...

Effect of short-term dietary administration of eugenol in humans

1. In order to study the antigenotoxic potential of eugenol in humans, ten healthy non-smoking males ingested a daily amount of 150 mg eugenol or the placebo for seven consecutive days. After a washout period of one week, groups ingesting eugenol or the placebo were crossed and received the other treatment for seven consecutive days. 2. On days...

Effect of a vegan diet on biomarkers of chemoprevention in females

1. In order to study the potential beneficial effects of a vegan diet, a cross-sectional study was performed and several biomarkers of chemoprevention were measured in a population of female 'living food' eaters ('vegans'; n = 20) vs matched omnivorous controls (n = 20). 2. White blood cells obtained from fresh blood samples were subjected to...

The micronucleus test with N-methyl-N'-nitro-N-nitrosoguanidine showing significant effects in bone marrow and peripheral blood of rats

Antimutagenicity of eugenol in the rodent bone marrow micronucleus test

Modifying effects of garlic constituents on cyclophosphamide and mitomycin C-induced (geno)toxicity in mouse bone marrow cells in vivo

Proceedings of the Netherlands Society of Toxicology Annual Meeting, Utrecht University, 13 January 1994: 1. trends in toxicological pathology; 2. posters

Het effect van B-caroteen suppletie op dna schade bij rokers

Congres van de Vereniging voor Epidemiologie 19e WEON-congres donderdag 15 april en vrijdag 16 april 1993 in et Academisch Centrum Amsterdam. Congres abstract.