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de Munk, G.A.W. (author), Parkinson, J.F. (author), Groeneveld, E. (author), Bang, N.U. (author), Rijken, D.C. (author), IVVO-TNO Gaubius Laboratory, PO Box 430, 2300 AK Leiden, Netherlands Instituut voor verouderings- en vaatziekten onderzoek TNO (author)Thrombomodulin (TM), a membrane proteoglycan on endothelial cells, binds thrombin in a 1:1 complex, accelerates the protein C activation by thrombin, promotes the thrombin inactivation by antithrombin III and inhibits the procoagulant properties of thrombin. The inactivation of single-chain urokinase-type plasminogen activator (scu-PA) by...article 1993
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de Munk, G.A.W. (author), Molinari, A. (author), Rijken, D.C. (author), Gaubius Laboratory Netherlands Instituut voor verouderings- en vaatziekten onderzoek TNO (author)Chemicals/CAS: amino acid, 65072-01-7; prourokinase, 82657-92-9; thrombin, 9002-04-4; thrombomodulin, 112049-68-0; Enzyme Precursors; Receptors, Cell Surface; Receptors, Thrombin; saruplase, 99149-95-8; Thrombin, EC 3.4.21.5; Urinary Plasminogen Activator, EC 3.4.21.73article 1993
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- Gaubius instituut Instituut voor verouderings- en vaatziekten onderzoek TNO (author), de Munk, G.A.W. (author) doctoral thesis 1993
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Instituut voor Verouderings- en Vaatziekten Onderzoek TNO (author), de Munk, G.A.W. (author), Groeneveld, E. (author), Rijken, D.C. (author)The in vitro effects of thrombomodulin on the inactivation of single chain urokinase-type plasminogen activator (scu-PA) by thrombin were investigated by incubating scu-PA with varying concentrations of human thrombin, in both the absence and presence of soluble rabbit thrombomodulin. 50% inactivation of scu-PA occurred in 45 min at 160 ng/ml...article 1991