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Klipstein-Grobusch, K. (author), Witteman, J.C.M. (author), den Breeijen, J.H. (author), Goldbohm, R.A. (author), Hofman, A. (author), de Jong, P.T.V.M. (author), Pols, H.A. (author), Grobbee, D.E. (author)Objective: Description and application of an adapted semiquantitative food frequency questionnaire (SFFQ) for dietary assessment in the elderly population of the Rotterdam Study. Design: Dietary assessment consisting of a two-step approach was performed in 5434 participants (2225 men, 3029 women) of the Rotterdam Study from 1990 to 1993, a...article 1999
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van der Bom, J.G. (author), de Maat, M.P.M. (author), Bots, M.L. (author), Haverkate, F. (author), de Jong, P.T.V.M. (author), Hofman, A. (author), Kluft, C. (author), Grobbee, D.E. (author), Gaubius Instituut TNO (author)An association between increased plasma fibrinogen and an increased risk for myocardial infarction (MI) is well established, but the nature of this association is subject to debate. Our aim was to shed light on the potentially causal nature of this association. We examined whether increased plasma fibrinogen, due to a condition that is...article 1998
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van der Bom, J.G. (author), de Knijff, P. (author), Haverkate, F. (author), Bots, M.L. (author), Meijer, P. (author), de Jong, P.T.V.M. (author), Hofman, A. (author), Kluft, C. (author), Grobbee, D.E. (author), Gaubius Instituut TNO (author)Background: Impaired fibrinolytic capacity, as assessed by euglobulin clot lysis time or plasma concentration of fibrinolytic parameters, has been associated with an increased risk of myocardial infarction (MI). We studied the association of a polymorphism in the gene for TPA and of plasma concentrations of TPA (antigen and activity) with the...article 1997
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Mennen, L.I. (author), de Maat, M.P.M. (author), Schouten, E.G. (author), Kluft, C. (author), de Jong, P.T.V.M. (author), Hofman, A. (author), Grobbee, D.E. (author), Gaubius Instituut TNO (author)Coagulation factor VII activity (FVII:C) is a risk indicator for cardiovascular disease. It is related to serum-triglycerides and the R/Q353 polymorphism (alleles R and Q) in the gene coding for factor VII is strongly associated with factor VU[. The association of serum-triglycerides with factor VII may differ between the genotypes, but the...article 1997
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van der Bom, J.G. (author), Bots, M.L. (author), Haverkate, F. (author), Slagboom, P.E. (author), Meijer, P. (author), de Jong, P.T.V.M. (author), Hofman, A. (author), Grobbee, D.E. (author), Kluft, C. (author), Gaubius Instituut TNO (author)Background: Resistance to activated protein C (APC), which results from various factors, including a mutation in the gene for coagulant factor V, has been associated with increased risk for venous thrombosis. However, its relation to arterial disease is still not well defined. Objective: To investigate the association of both response to APC and...article 1996