Searched for: author%3A%22de+Groot%2C+J.%22
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Vlaming, M.L.H. (author), Läppchen, T. (author), Jansen, H.T. (author), Kivits, S. (author), van Driel, A. (author), van der Steeg, E. (author), van der Hoorn, J.W. (author), Sio, C.F. (author), Steinbach, O.C. (author), de Groot, J. (author)
Introduction: The efflux transporters P-glycoprotein (P-gp, ABCB1) and breast cancer resistance protein (BCRP, ABCG2) are expressed at the blood-brain barrier (BBB), and can limit the access of a wide range of drugs to the brain. In this study we developed a PET-CT imaging method for non-invasive, quantitative analysis of the effect of ABCB1 and...
article 2015
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Vos, P.A.J.M. (author), Welsing, P.M.J. (author), de Groot, J. (author), Huisman, A.M. (author), Oostveen, J.C.M. (author), Reijman, M. (author), Damen, J. (author), Mastbergen, S.C. (author), Lafeber, F.P.J.G. (author)
Age-related changes in articular cartilage are likely to play a role in the etiology of osteoarthritis (OA). One of the major age-related changes in cartilage is the accumulation of advanced glycation end products (AGEs). The present study evaluates whether pentosidine can predict radiographic progression and/or burden over 5 years follow-up in...
article 2013
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Clabbers, N. (author), van Dijken, P. (author), van Gool, A. (author), van der Greef, J. (author), de Groot, J. (author), Hendriks, H. (author), van Meeteren, N. (author), Mooij, R. (author), van Ommen, B. (author), Rietkerk, O. (author), Snoeij, N. (author), van Staalduinen, W. (author), Stadlander, M. (author), Wevers, C. (author), Wieringa, F. (author)
report 2013
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Vos, P.A.J.M. (author), Mastbergen, S.C. (author), Huisman, A.M. (author), de Boer, T.N. (author), de Groot, J. (author), Polak, A.A. (author), Lafeber, F.P.J.G. (author)
Objectives: Age is the most prominent predisposition for development of osteoarthritis (OA). Age-related changes of articular cartilage are likely to play a role. Advanced glycation endproducts (AGEs) accumulate in cartilage matrix with increasing age and adversely affect the biomechanical properties of the cartilage matrix and influence...
article 2012
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van Spil, W.E. (author), Jansen, N.W.D. (author), Bijlsma, J.W.J. (author), Reijman, M. (author), de Groot, J. (author), Welsing, P.M.J. (author), Lafeber, F.P.J.G. (author)
Objective: To assess a wide spectrum of biochemical markers (biomarkers) in a large cohort of individuals with (very) early symptomatic knee and/or hip osteoarthritis (OA). Secondly, to investigate associations between biomarkers and between biomarkers and demographics to demonstrate validity of the obtained dataset and further investigate the...
article 2012
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Bastiaansen-Jenniskens, Y.M. (author), Clockaerts, S. (author), Feijt, C. (author), Zuurmond, A.M. (author), Stojanovic-Susulic, V. (author), Bridts, C. (author), de Clerck, L. (author), de Groot, J. (author), Verhaar, J.A.N. (author), Kloppenburg, M. (author), van Osch, G.J.V.M. (author)
Objective: Adipose tissue is known to release inflammatory cytokines and growth factors. In this exploratory study, the authors examined whether the infrapatellar fat pad (IPFP) closely located to cartilage in the knee joint can affect cartilage metabolism. In addition, the authors analysed whether the macrophage types present in IPFP could...
article 2012
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Zuurmond, A.M. (author), Koudijs, A. (author), van El, B. (author), Doornbos, R.P. (author), van Manen-Vernooij, B.C.T. (author), Bastiaans, J.H.M.W. (author), Penninks, A.H. (author), van Bilsen, J.H.M. (author), Cnubben, N.H.P. (author), de Groot, J. (author)
Pharmacokinetic properties and safety profile of a drug are likely influenced by the disease state of a patient. In this study, we investigated the influence of arthritic processes on pharmacokinetics and immunotoxicity of interleukin-1 receptor antagonist (Anakinra) in the rat adjuvant arthritis model. Anakinra dose-dependently suppressed joint...
article 2011
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Smeets, M.A.M. (author), Toet, A. (author), Duinkerken, R. (author), de Groot, J. (author), Kaldewaij, A. (author), van den Hout, M.A. (author)
Females evaluate ambiguous facial expression – morphed between happy and fearful – faces as more fearful when exposed to fear sweat as compared to control odor (Zhou & Chen, 2009). We investigated the specificity of this effect, i.e. whether processing of fearful faces is affected specifically by fear sweat. In Study 1, we investigated the...
conference paper 2011
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Castro-Perez, J.M. (author), Kamphorst, J. (author), de Groot, J. (author), Lafeber, F. (author), Goshawk, J. (author), Yu, K. (author), Shockcor, J.P. (author), Vreeken, R.J. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)
A fast and robust method for lipid profiling utilizing liquid chromatography coupled with mass spectrometry has been demonstrated and validated for the analysis of human plasma. This method allowed quantification and identification of lipids in human plasma using parallel alternating low energy and high energy collision spectral acquisition...
article 2010
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den Ridder, K. (author), Tuiters, Y. (author), van der Tuijn, Y. (author), van Bon, A. (author), Bolle, F. (author), van den Bos, A. (author), Brinkhof, K. (author), van den Elzen, G. (author), Fledderus-Plaisier, C. (author), Geurts, L. (author), Gooskens, F. (author), van Harten-Krouwel, D. (author), Hormann, O. (author), Kievit, L. (author), Kluijver, B. (author), Kramer, Y. (author), Mak, M. (author), Mintjes-de Groot, J. (author), Ram, C. (author), Smit, M. (author), Schoone-Harmsen, M. (author), van der Starre, C. (author), van Valkenburg, M. (author), Vermaas, A. (author), Vesseur, J. (author), Zeeman, G.G. (author), Zwart, D. (author), TNO Kwaliteit van Leven (author)
Verpleegkundige Martine werkt op de short-stayafdeling van een ziekenhuis. Op dit moment heeft ze samen met een nauwelijks ingewerkte leerlingverpleegkundige de zorg voor zestien patiënten; draagt ze de afdelingstelefoon bij zich en staat ze op het punt de medicijnen uit te delen aan haar patiënten. Maar helaas kan ze met haar medicijnkar niet...
book 2010
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Intema, F. (author), Sniekers, Y.H. (author), Weinans, H. (author), Vianen, M.E. (author), Yocum, S.A. (author), Zuurmond, A.-M.M. (author), de Groot, J. (author), Lafeber, F.P. (author), Mastbergen, S.C. (author), TNO Kwaliteit van Leven (author)
In osteoarthritis (OA), cartilage degradation is accompanied by subchondral bone changes. The pathogenesis and physiology of bone changes in OA are still unclear. The changes in subchondral bone architecture and cartilage damage were compared in differently induced experimental models of OA. Experimental OA was induced bilaterally by anterior...
article 2010
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Vos, P.A.J.M. (author), de Groot, J. (author), Huisman, A.M. (author), Oostveen, J.C.M. (author), Marijnissen, A.C.A. (author), Bijlsma, J.W.J. (author), van El, B. (author), Zuurmond, A.M. (author), Lafeber, F.P.J.G. (author), TNO Kwaliteit van Leven (author)
Objectives: Age-related changes in articular cartilage are likely to play a role in the aetiology of osteoarthritis (OA). One of the major age-related changes in cartilage is the accumulation of advanced-glycation-endproducts (AGEs). Since, cartilage tissue is not readily available from patients for studying AGE levels, alternative approaches...
article 2010
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van Spil, W.E. (author), de Groot, J. (author), Lems, W.F. (author), Oostveen, J.C.M. (author), Lafeber, F.P.J.G. (author), TNO Kwaliteit van Leven (author)
Context: Molecules that are released into biological fluids during matrix metabolism of articular cartilage, subchondral bone, and synovial tissue could serve as biochemical markers of the process of osteoarthritis (OA). Unfortunately, actual breakthroughs in the biochemical OA marker field are limited so far. Objective: By reviewing the status...
article 2010
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TNO Kwaliteit van Leven (author), Tak, P.P. (author), van Kuijk, A.W.R. (author), de Groot, J. (author), Koeman, R.C. (author), Sakkee, N. (author), Baeten, D.L. (author), Gerlag, D.M. (author)
Background: There is growing interest in soluble biomarkers that could be used on the group level for screening purposes in small proof of principle studies during early drug development. We investigated early changes in serum levels of several candidate biomarkers involved in cartilage and bone metabolism following the initiation of adalimumab...
article 2010
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TNO Kwaliteit van Leven (author), Yusuf, E. (author), Nelissen, R.G. (author), Ioan-Facsinay, A. (author), Stojanovic-Susulic, V. (author), de Groot, J. (author), van Osch, G. (author), Middeldorp, S. (author), Huizinga, T.W.J. (author), Kloppenburg, M. (author)
Objective: To investigate the association between weight or body mass index (BMI) and the development of hand osteoarthritis. Methods: Systematic review of observational studies. Medical databases were searched up to April 2008. Articles that presented data on the association between weight and hand osteoarthritis were selected. The qualities of...
article 2010
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TNO Defensie en Veiligheid (author), Smeets, M.A.M. (author), de Groot, J. (author), Kaldewaij, A. (author), Toet, A. (author), van Doornen, L. (author)
conference paper 2010
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Kamphorst, J.J. (author), Tjaden, U.R. (author), van der Heijden, R. (author), de Groot, J. (author), van der Greef, J. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)
Considerable interest exists in endogenous peptides as potential biomarkers, since they act as signaling molecules and are formed by degradation of proteins. A crucial step in the profiling of these peptides is the sample preparation, which aims to enrich the low-abundant peptides, while removing interfering matrix compounds. In a feasibility...
article 2009
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Vos, P. (author), Intema, F. (author), van El, B. (author), de Groot, J. (author), Bijlsma, J.W.J. (author), Lafeber, F. (author), Mastbergen, S. (author), TNO Kwaliteit van Leven (author)
Many animal models are used to study osteoarthritis (OA). In these models the role of joint loading in the development of OA is not fully understood. We studied the effect of loading on the development of OA in the canine Groove-model. In ten female beagle dogs OA was induced in one knee according to the Groove-model. The animals were divided in...
article 2009
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Blumbach, K. (author), Bastiaansen-Jenniskens, Y.M. (author), de Groot, J. (author), Paulsson, M. (author), van Osch, G.J.V.M. (author), Zaucke, F. (author), TNO Kwaliteit van Leven (author)
Objective. Defects in the assembly and composition of cartilage extracellular matrix are likely to result in impaired matrix integrity and increased susceptibility to cartilage degeneration. The aim of this study was to determine the functional interaction of the collagen fibril-associated proteins type IX collagen and cartilage oligomeric...
article 2009
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Bastiaansen-Jenniskens, Y.M. (author), Koevoet, W. (author), Jansen, K.M.B. (author), Verhaar, J.A.N. (author), de Groot, J. (author), Vanosch, G.J.V.M. (author), TNO Kwaliteit van Leven (author)
To understand cartilage degenerative diseases and improve repair procedures, we investigate the influence of glycosaminoglycans (GAGs) on cartilage matrix biochemistry and functionality. Bovine articular chondrocytes were cultured in alginate beads with(out) para-nitrophenyl-beta-d-xyloside (PNPX) to inhibit GAG incorporation into newly formed...
article 2009
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