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Onder, S. (author), van Grol, M. (author), Fidder, A. (author), Xiao, G. (author), Noort, D. (author), Yerramalla, U. (author), Tacal, O. (author), Schopfer, L.M. (author), Lockridge, O. (author)Chronic low-dose exposure to organophosphorus pesticides is associated with the risk of neurodegenerative disease. The mechanism of neurotoxicity is independent of acetylcholinesterase inhibition. Adducts on tyrosine, lysine, threonine, and serine can occur after exposure to organophosphorus pesticides, the most stable being adducts on tyrosine....article 2021
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Bentz, J. (author), O'Connor, M.P. (author), Bednarczyk, D. (author), Coleman, J. (author), Lee, C. (author), Palm, J. (author), Pak, Y.A. (author), Perloff, E.S. (author), Reyner, E. (author), Balimane, P. (author), Brännström, M. (author), Chu, X. (author), Funk, C. (author), Guo, A. (author), Hanna, I. (author), Herédi-Szabó, K. (author), Hillgren, K. (author), Li, L. (author), Hollnack-Pusch, E. (author), Jamei, M. (author), Lin, X. (author), Mason, A.K. (author), Neuhoff, S. (author), Patel, A. (author), Podila, L. (author), Plise, E. (author), Rajaraman, G. (author), Salphati, L. (author), Sands, E. (author), Taub, M.E. (author), Taur, J.-S. (author), Weitz, D. (author), Wortelboer, H.M. (author), Xia, C.Q. (author), Xiao, G. (author), Yabut, J. (author), Yamagata, T. (author), Zhang, L. (author), Ellens, H. (author)A P-glycoprotein (P-gp) IC50 working group was established with 23 participating pharmaceutical and contract research laboratories and one academic institution to assess interlaboratory variability in P-gp IC 50 determinations. Each laboratory followed its in-house protocol to determine in vitro IC50 values for 16 inhibitors using four different...article 2013
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Ellens, H. (author), Deng, S. (author), Coleman, J. (author), Bentz, J. (author), Taub, M.E. (author), Ragueneau-Majlessi, I. (author), Chung, S.P. (author), Herédi-Szabó, K. (author), Neuhoff, S. (author), Palm, J. (author), Balimane, P. (author), Zhang, L. (author), Jamei, M. (author), Hanna, I. (author), O'connor, M. (author), Bednarczyk, D. (author), Forsgard, M. (author), Chu, X. (author), Funk, C. (author), Guo, A. (author), Hillgren, K.M. (author), Li, L. (author), Pak, A.Y. (author), Perloff, E.S. (author), Rajaraman, G. (author), Salphati, L. (author), Taur, J.-S. (author), Weitz, D. (author), Wortelboer, H.M. (author), Xia, C.Q. (author), Xiao, G. (author), Yamagata, T. (author), Lee, C.A. (author)In the 2012 Food and Drug Administration (FDA) draft guidance on drug-drug interactions (DDIs), a new molecular entity that inhibits Pglycoprotein (P-gp) may need a clinical DDI study with a P-gp substrate such as digoxin when themaximumconcentration of inhibitor at steady state divided by IC50 ([I1]/IC50) is0.1 or concentration of inhibitor...article 2013
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Sun, A. (author), Dai, Y. (author), Zhang, X. (author), Li, C. (author), Meng, K. (author), Xu, H. (author), Wei, X. (author), Xiao, G. (author), Ouwerkerk, P.B. (author), Wang, M. (author), Zhu, Z. (author)In many plants, sucrose transporters are essential for both sucrose exports from sources and imports into sinks, indicating a function in assimilate partitioning. To investigate whether sucrose transporters can improve the yield of starch plant, potato plants (Solanum tuberosum L. cv. Désirée) were transformed with cDNAs of the rice sucrose...article 2011
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Wang, Y. (author), Xu, H. (author), Wei, X. (author), Chai, C. (author), Xiao, Y. (author), Zhang, Y. (author), Chen, B. (author), Xiao, G. (author), Ouwerkerk, P.B.F. (author), Wang, M. (author), Zhu, Z. (author), TNO Kwaliteit van Leven (author)Monosaccharide transporters mediate the membrane transport of a variable range of monosaccharides, which plays a crucial role in sugar distribution throughout the plant. To investigate the significance of monosaccharide transporters for rice (Oryza sativa L.) seed development, cDNA of a new putative monosaccharide transporter gene OsMST4 was...article 2007