Developing a Personalized Integrative Obesity-Coaching Program: A Systems Health Perspective

Current obesity management strategies are failing to achieve sustainable and favorable long-term results. We propose a more personalized, dynamic, and systemic perspective on the interactions of key determinants and coaching advice on obesity. The aim of this study was to use a systems view on overweight, complexity science, and a...

Gezamenlijk gezondheid en welbevinden van werknemers duurzaam verhogen: wellbeing dashboard

Het aantal werkenden met chronische stressklachten stijgt. Mentale klachten zijn op dit moment de belangrijkste oorzaak van ziekteverzuim en uitval van werknemers. Hoewel er de afgelopen 30 jaar steeds meer aandacht is voor dit probleem, lukt het niet de trend te keren. Daarom werkt TNO met partners aan een systeemoplossing voor het behouden van...

Link-based influence maximization in networks of health promotion professionals

The influence maximization problem (IMP) as classically formulated is based on the strong assumption that “chosen” nodes always adopt the new product. In this paper we propose a new influence maximization problem, referred to as the “Link-based Influence Maximization Problem” (LIM), which differs from IMP in that the decision variable of the...

Met een integrale aanpak op maat werkstress terugdringen

Werk gerelateerde stress heeft grote maatschappelijke en economische gevolgen. Al jarenlang nemen stress en stress gerelateerde klachten bij werkende mensen toe. Dit uit zich in uitval als gevolg van deze klachten (burn-out), verminderde prestaties en inzetbaarheid en oplopende verzuimkosten. Werkstress zorgt voor persoonlijk leed bij...

Ussing Chamber

The Ussing chamber system is named after the Danish zoologist Hans Ussing, who invented the device in the 1950s to measure the short-circuit current as an indicator of net ion transport taking place across frog skin (Ussing and Zerahn, Acta Physiol Scand 23:110-127, 1951). Ussing chambers are increasingly being used to measure ion transport in...

Parallelogram approach using rat-human In vitro and rat in vivo toxicogenomics predicts acetaminophen-induced hepatotoxicity in humans

The frequent use of rodent hepatic in vitro systems in pharmacological and toxicological investigations challenges extrapolation of in vitro results to the situation in vivo and interspecies extrapolation from rodents to humans. The toxicogenomics approach may aid in evaluating relevance of these model systems for human risk assessment by direct...

The interplay of glutathione-related processes in antioxidant defense

This review summarizes current knowledge on glutathione (GSH) associated cellular processes that play a central role in defense against oxidative stress. GSH itself is a critical factor in maintaining the cellular redox balance and has been demonstrated to be involved in regulation of cell signalling and repair pathways. Enhanced expression of...