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Wopereis, S. (author), Boorsma, A. (author)We are all getting older, but enjoying a long and healthy life is not a given. Our quality of life is declining. Although our lifespan continues to increase, our healthy years have declined. In short, we are mostly living longer but in poor health1. More and more people are developing chronic, lifestyle-related conditions, such as type 2...report 2023
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van den Brink, W.J. (author), van den Broek, T.J. (author), Palmisano, S. (author), Wopereis, S. (author), de Hoogh, I.M. (author)Digital health technologies may support the management and prevention of disease through personalized lifestyle interventions. Wearables and smartphones are increasingly used to continuously monitor health and disease in everyday life, targeting health maintenance. Here, we aim to demonstrate the potential of wearables and smartphones to (1)...article 2022
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Gijbels, A. (author), Schutte, S. (author), Esser, D. (author), Wopereis, S. (author), Gonzales, G.B. (author), Afman, L.A. (author)Background: We previously showed that whole-grain wheat (WGW) consumption had beneficial effects on liver fat accumulation, as compared to refined wheat (RW). The mechanisms underlying these effects remain unclear. Objective: In this study, we investigated the effects of WGW vs. RW consumption on plasma metabolite levels to explore potential...article 2022
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Michielsen, C.C.J.R. (author), Hangelbroek, R.W.J. (author), Bragt, M.C.E. (author), Verheij, E.R. (author), Wopereis, S. (author), Mensink, R.P. (author), Afman, L.A. (author)Scope: The drug fenofibrate and dietary fish oils can effectively lower circulating triglyceride (TG) concentrations. However, a detailed comparative analysis of the effects on the plasma metabolome is missing. Methods and Results: Twenty overweight and obese subjects participate in a double-blind, cross-over intervention trial and receive in a...article 2022
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de Hoogh, I.M. (author), van der Kamp, J.W. (author), Wopereis, S. (author)Highlights. Personalized nutrition approaches can promote dietary behaviour change. Personalization increases individual’ relevance and taps into intrinsic motivation. Studies show personalized nutrition can help increase wholegrain consumption. Personalized approaches can contribute to novel tailored wholegrain recommendations.article 2022
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Fiamoncini, J. (author), Donado-Pestana, C.M. (author), Duarte, G.B.S. (author), Rundle, M. (author), Thomas, E.L. (author), Kiselova-Kaneva, Y. (author), Gundersen, T.E. (author), Bunzel, D. (author), Trezzi, J.P. (author), Kulling, S.E. (author), Hiller, K. (author), Sonntag, D. (author), Ivanova, D. (author), Brennan, L. (author), Wopereis, S. (author), van Ommen, B. (author), Frost, G. (author), Bell, J. (author), Drevon, C.A. (author), Daniel, H. (author)Insulin secretion following ingestion of a carbohydrate load affects a multitude of metabolic pathways that simultaneously change direction and quantity of interorgan fluxes of sugars, lipids and amino acids. In the present study, we aimed at identifying markers associated with differential responses to an OGTT a population of healthy adults. By...article 2022
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de Hoogh, I.M. (author), Pasman, W.J. (author), Boorsma, A. (author), van Ommen, B. (author), Wopereis, S. (author)A type 2 diabetes mellitus (T2DM) subtyping method that determines the T2DM phenotype based on an extended oral glucose tolerance test is proposed. It assigns participants to one of seven subtypes according to their β-cell function and the presence of hepatic and/or muscle insulin resistance. The effectiveness of this subtyping approach and...article 2022
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Wopereis, S. (author)Phenotypic flexibility is a methodology that accurately assesses health in terms of mechanistic understanding of the interrelationship of multiple metabolic and physiological processes. This starts from the perspective that a healthy person is better able to cope with changes in environmental stressors that affect homeostasis compared to people...conference paper 2022
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de Hoogh, I.M. (author), Oosterman, J.E. (author), Otten, W. (author), Krijger, A.M. (author), Berbée-Zadelaar, S. (author), Pasman, W.J. (author), van Ommen, B. (author), Pijl, H. (author), Wopereis, S. (author)Although lifestyle interventions can lead to diabetes remission, it is unclear to what extent type 2 diabetes (T2D) remission alters or improves the underlying pathophysiology of the disease. Here, we assess the effects of a lifestyle intervention on T2D reversal or remission and the effects on the underlying pathology. In a Dutch primary care...article 2021
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Memelink, R.G. (author), Pasman, W.J. (author), Bongers, A. (author), Tump, A. (author), van Ginkel, A. (author), Tromp, W. (author), Wopereis, S. (author), Verlaan, S. (author), den Bosch, J.V.V. (author), Weijs, P.J.M. (author)Background: Weight loss is key to treatment of older adults with obesity and type 2 diabetes, but also a risk for muscle mass loss. This study investigated whether a whey protein drink enriched with leucine and vitamin D could preserve muscle mass and improve glycemic control during combined lifestyle intervention in this population. Methods:...article 2021
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van Trijp, M.P.H. (author), Schutte, S. (author), Esser, D. (author), Wopereis, S. (author), Hoevenaars, F.P.M. (author), Hooiveld, G.J.E.J. (author), Afman, L.A. (author)Background: Whole grain wheat (WGW) products are advocated as a healthy choice when compared with refined wheat (RW). One proposed mechanism for these health benefits is via the microbiota, because WGW contains multiple fibers. WGW consumption has been proposed to ameliorate nonalcoholic fatty liver disease, in which microbiota might play a role...article 2021
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van den Brink, W. (author), Bloem, R. (author), Ananth, A. (author), Kanagasabapathi, T. (author), Amelink, A. (author), Bouwman, J. (author), Gelinck, G.H. (author), van Veen, S. (author), Boorsma, A. (author), Wopereis, S. (author)Health maintenance and disease prevention strategies become increasingly prioritized with increasing health and economic burden of chronic, lifestyle-related diseases. A key element in these strategies is the empowerment of individuals to control their health. Self-measurement plays an essential role in achieving such empowerment. Digital...article 2021
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de Hoogh, I.M. (author), Winters, B.L. (author), Nieman, K.M. (author), Bijlsma, S. (author), Krone, T. (author), van den Broek, T.J. (author), Anderson, B.D. (author), Caspers, M.P.M. (author), Anthony, J.C. (author), Wopereis, S. (author)Personalized nutrition may be more effective in changing lifestyle behaviors compared to population-based guidelines. This single-arm exploratory study evaluated the impact of a 10-week personalized systems nutrition (PSN) program on lifestyle behavior and health outcomes. Healthy men and women (n = 82) completed the trial. Individuals were...article 2021
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Kim, Y. (author), Kim, Y. (author), Hwang, J. (author), van den Broek, T.J. (author), Oh, B. (author), Kim, J.Y. (author), Wopereis, S. (author), Bouwman, J. (author), Kwon, O. (author)Oxidative stress aggravates the progression of lifestyle-related chronic diseases. However, knowledge and practices that enable quantifying oxidative stress are still lacking. Here, we performed a proof-of-concept study to predict the oxidative stress status in a healthy population using retrospective cohort data from Boramae medical center in...article 2021
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Haji, M. (author), Memelink, R.G. (author), Brandt, B.W. (author), Buijs, M.J. (author), Pasman, W.J. (author), de Vogel-Bosch, J. (author), Wopereis, S. (author), Zaura, E. (author), Weijs, P.J.M. (author)Rationale: While combined lifestyle interventions have multiple health benefits, their impact on the oral microbiome is not known. We explored the effects of a lifestyle intervention including protein drink on the oral microbiome in older adults with obesity and type 2 diabetes (T2D). Methods: In a post-hoc analysis of the PROBE study, 87...article 2021
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van Bilsen, J.H.M. (author), van den Brink, W. (author), van den Hoek, A.M. (author), Dulos, R. (author), Caspers, M.P.M. (author), Kleeman, R. (author), Wopereis, S. (author), Verschuren, L. (author)Metabolic disorders, such as obesity and type 2 diabetes have a large impact on global health, especially in industrialized countries. Tissue-specific chronic low-grade inflammation is a key contributor to complications in metabolic disorders. To support therapeutic approaches to these complications, it is crucial to gain a deeper understanding...article 2021
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Wickramasinghe, K. (author), Mathers, J.C. (author), Wopereis, S. (author), Marsman, D.S. (author), Griffiths, J.C. (author)Across the globe, there has been a marked increase in longevity, but significant inequalities remain. These are exacerbated by inadequate access to proper nutrition and health care services and to reliable information to make the decisions related to nutrition and health care. Many in economically developing as well as developed societies are...article 2020
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Memelink, R. (author), Bongers, A. (author), Pasman, W. (author), van Rijmenam, M. (author), Wopereis, S. (author), Verlaan, G. (author), de Vogel Van den Bosch, J (author), Weijs, P.J.M. (author)Objectives. Weight loss is a key element in the treatment of obesity and type 2 diabetes (T2D), but also a risk factor for lean mass (LM) loss in older adults. We evaluated whether a whey protein drink enriched with leucine and vitamin D preserved LM during 3-month lifestyle intervention and whether effects sustained during 6 months follow-up...article 2020
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Kelly, J.M. (author), Matuszek, G. (author), van den Broek, T.J. (author), Huggins, G.S. (author), Smith, C.E. (author), Ordovas, J.M. (author), Wopereis, S. (author), Booth, S.L. (author)Inconsistent associations between lipids and circulating markers of fat-soluble vitamin and carotenoid status have been reported. The aim of this hypothesis-generating study was to examine the contribution of the LC-MS-based lipidome, characterized by lipid class, carbon count, and the number of unsaturated bonds, to the interindividual...article 2020
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Adams, S.H. (author), Anthony, J.C. (author), Carvajal, R. (author), Chae, L. (author), Khoo, C.S.H. (author), Latulippe, M.E. (author), Matusheski, N.V. (author), McClung, H.L. (author), Rozga, M. (author), Schmid, C.H. (author), Wopereis, S. (author), Yan, W. (author)Personalized nutrition (PN) approaches have been shown to help drive behavior change and positively influence health outcomes. This has led to an increase in the development of commercially available PN programs, which utilize various forms of individual-level information to provide services and products for consumers. The lack of a well...article 2020