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Janssen-Duijghuijsen, L.M. (author), Wichers, H.J. (author), van Norren, K. (author), Keijer, J. (author), Baumert, J.L. (author), de Jong, G.A.H. (author), Witkamp, R.F. (author), Koppelman, S.J. (author)Some studies have suggested that allergens may appear in the circulation after ingestion of allergenic food sources. The reported levels of allergen in serum, however, are low, and conclusions between studies differ. Here, we investigated factors that determine the detection of allergens in serum after consumption of peanuts. Ten healthy...article 2017
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Ripken, D. (author), van Avesaat, M. (author), Troost, F.J. (author), Masclee, A.A. (author), Witkamp, R.F. (author), Hendriks, H.F. (author)Background. Activation of the ileal brake by casein induces satiety signals and reduces energy intake. However, adverse effects of intraileal casein administration have not been studied before. These adverse effects may include impaired amino acid digestion, absorption and immune activation. Objective. To investigate the effects of intraileal...article 2017
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Ripken, D. (author), van der Wielen, N. (author), Wortelboer, H.M. (author), Meijerink, J. (author), Witkamp, R.F. (author), Hendriks, H.F.J. (author)Glucagon like peptide-1 (GLP-1) and serotonin are both involved in food intake regulation. GLP-1 release is stimulated upon nutrient interaction with G-protein coupled receptors by enteroendocrine cells (EEC), whereas serotonin is released from enterochromaffin cells (ECC). The central hypothesis for the current study was that nutrient-induced...article 2016
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Schrieks, I.C. (author), Joosten, M.M. (author), Klöpping-Ketelaars, W.A.A. (author), Witkamp, R.F. (author), Hendriks, H.F.J. (author)Alcohol is often consumed to reduce tension and improve mood when exposed to stressful situations. Previous studies showed that moderate alcohol consumption may reduce stress when alcohol is consumed prior to a stressor, but data on the effect of alcohol consumption after a mental stressor is limited. Therefore, our objective was to study...article 2016
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Ripken, D. (author), van der Wielen, N. (author), van der Meulen, J. (author), Schuurman, T. (author), Witkamp, R.F. (author), Hendriks, H.F.J. (author), Koopmans, S.J. (author)The vagal nerve and gut hormones CCK and GLP-1 play important roles in the control of food intake. However, it is not clear to what extent CCK and GLP-1 increase satiation by stimulating receptors located on abdominal vagal nerve endings or via receptors located elsewhere. This study aimed to further explore the relative contribution of the...article 2015
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Schrieks, I.C. (author), Stafleu, A. (author), Griffioen-Roose, S. (author), de Graaf, C. (author), Witkamp, R.F. (author), Boerrigter-Rijneveld, R. (author), Hendriks, H.F.J. (author)The aim of this study was to investigate whether food reward plays a role in the stimulating effect of moderate alcohol consumption on subsequent food intake. In addition, we explored the role of oral and gut sensory pathways in alcohol's effect on food reward by modified sham feeding (MSF) or consumption of a preload after alcohol intake.In a...article 2015
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- Schrieks, I.C. (author), Stafleu, A. (author), Kallen, V.L. (author), Grootjen, M. (author), Witkamp, R.F. (author), Hendriks, H.F.J. (author) article 2015
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Schrieks, I.C. (author), Ripken, D. (author), Stafleu, A. (author), Witkamp, R.F. (author), Hendriks, H.F.J. (author)Background: The endocannabinoid system is suggested to play a regulatory role in mood. However, the response of circulating endocannabinoids (ECs) to mood changes has never been tested in humans. In the present study, we examined the effects of mood changes induced by ambiance and moderate alcohol consumption on plasma ECs 2-arachidonoylglycerol...article 2015
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Ripken, D. (author), van der Wielen, N. (author), Wortelboer, H.M. (author), Meijerink, J. (author), Witkamp, R.F. (author), Hendriks, H.F.J. (author)Glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) are hormones important for satiation and are involved in the process called “ileal brake”. The aim of this study was to investigate the GLP-1- and PYY-stimulating efficacy of rebaudioside A, casein, and sucrose. This was studied using tissue segments collected from various regions of the pig...article 2014
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Schrieks, I.C. (author), Stafleu, A. (author), Kallen, V.L. (author), Grootjen, M. (author), Witkamp, R.F. (author), Hendriks, H.F.J. (author)Background: The pre-drinking mood state has been indicated to be an important factor in the mood effects of alcohol. However, for moderate alcohol consumption there are no controlled studies showing this association. Also, the mood effects of consuming alcohol combined with food are largely unknown. The aim of this study was to investigate the...article 2014
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Balvers, M.G.J. (author), Wortelboer, H.M. (author), Witkamp, R.F. (author), Verhoeckx, K.C.M. (author)The origin of N-acyl ethanolamides (NAEs) in plasma is not well understood, and it is possible that NAEs are present in plasma in esterified form. To test this hypothesis, a new and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the quantification of arachidonoyl ethanolamide, 2...article 2013
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Balvers, M.G.J. (author), Verhoeckx, K.C.M. (author), Meijerink, J. (author), Wortelboer, H.M. (author), Witkamp, R.F. (author)Palmitoylethanolamide (PEA) belongs to the N-acyl ethanolamines (NAEs), a group of endogenous compounds involved in a variety of physiological processes, including energy homeostasis and inflammation. This review focuses on the analysis of PEA in plasma and tissues and discusses effects of diet and some pathological processes on PEA levels....article 2013
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Voortman, T. (author), Hendriks, H.F.J. (author), Witkamp, R.F. (author), Wortelboer, H.M. (author)Gastrointestinal (GI) peptide hormones play an important role in short-term regulation of food intake and blood glucose levels. Modulating their release is of potential relevance for weight management and possibly diabetes. As currently available models are hard to extrapolate to the human situation, the use of porcine intestinal tissue,...article 2012
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Balvers, M.G.J. (author), Verhoeckx, K.C.M. (author), Meijerink, J. (author), Bijlsma, S. (author), Rubingh, C.M. (author), Wortelboer, H.M. (author), Witkamp, R.F. (author)Eicosanoids and endocannabinoids/N-acylethanolamines (NAEs) are fatty acid derived compounds with a regulatory role in inflammation. Considering their complex metabolism, it is likely that inflammation affects multiple compounds at the same time, but how lipid profiles change in plasma and other tissues after an inflammatory stimulus has not...article 2012
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- Joosten, M.M., (author), van, Erk, M.J. (author), Pellis, L, (author), Witkamp, R.F., (author), Hendriks, H.F. (author) article 2012
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Wei, H. (author), Hu, C. (author), Wang, M. (author), van den Hoek, A.M. (author), Reijmers, T.H. (author), Wopereis, S. (author), Bouwman, J. (author), Ramaker, R. (author), Korthout, H.A.A.J. (author), Vennik, M. (author), Hankemeier, T. (author), Havekes, L.M. (author), Witkamp, R.F. (author), Verheij, E.R. (author), Xu, G. (author), van der Greef, J. (author)Background: Causes and consequences of the complex changes in lipids occurring in the metabolic syndrome are only partly understood. Several interconnected processes are deteriorating, which implies that multi-target approaches might be more successful than strategies based on a limited number of surrogate markers. Preparations from Chinese...article 2012
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Balvers, M.G.J. (author), Verhoeckx, K.C.M. (author), Wortelboer, H.M. (author), Bijlsma, S. (author), Rubingh, C.M. (author), Meijerink, J. (author), Witkamp, R.F. (author)It is well established that dietary intake of n-3 fatty acids is associated with anti-inflammatory effects, and this has been linked to modulation of the oxylipin and endocannabinoid metabolomes. However, the amount of data on specific tissue effects is limited, and it is not known how inflammation affects this relation. In the present study we...article 2012
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Biesalski, H.K. (author), Aggett, P.J. (author), Anton, R. (author), Bernstein, P.S. (author), Blumberg, J. (author), Heaney, R.P. (author), Henry, J. (author), Nolan, J.M. (author), Richardson, D.P. (author), van Ommen, B. (author), Witkamp, R.F. (author), Rijkers, G.T. (author), Zöllner, I. (author)Objective: The objective was to define the term evidence based nutrition on the basis of expert discussions and scientific evidence. Methods and procedures: The method used is the established Hohenheim Consensus Conference. The term "Hohenheim Consensus Conference" defines conferences dealing with nutrition-related topics. The major aim of the...article 2011
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Joosten, M.M. (author), Witkamp, R.F. (author), Hendriks, H.F.J. (author)Moderate alcohol consumption is associated with increased concentrations of adiponectin. Whether this is the case for both total and high-molecular-weight (HMW) adiponectin is uncertain. Furthermore, the rate at which this increase occurs is unclear. Therefore, we examined the effect of moderate alcohol consumption on total and HMW adiponectin....article 2011
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Meijerink, J. (author), Plastina, P. (author), Vincken, J.P. (author), Poland, M. (author), Attya, M. (author), Balvers, M. (author), Gruppen, H. (author), Gabriele, B. (author), Witkamp, R.F. (author)Several mechanisms have been proposed for the positive health effects associated with dietary consumption of long-chain n-3 PUFA (n-3 LC-PUFA) including DHA (22 : 6n-3) and EPA (20 : 5n-3). After dietary intake, LC-PUFA are incorporated into membranes and can be converted to their corresponding N-acylethanolamines (NAE). However, little is known...article 2011