The serosal immune system of the thorax in toxicology

The thoracic cavities receive increasing attention in toxicology, because inhaled fibers and (nano)particles can reach these cavities and challenge the local lymphoid tissues. The thoracic and abdominopelvic cavities are controlled by the serosal immune system with its special, loosely organized lymphoid clusters, namely the fat-associated...

Do aberrant crypt foci have predictive value for the occurrence of colorectal tumours? Potential of gene expression profiling in tumours

The effects of different dietary compounds on the formation of aberrant crypt foci (ACF) and colorectal tumours and on the expression of a selection of genes were studied in rats. Azoxymethane-treated male F344 rats were fed either a control diet or a diet containing 10% wheat bran (WB), 0.2% curcumin (CUR), 4% rutin (RUT) or 0.04% benzyl...

Effects of dietary fibre and fat on colorectal carcinogenesis in rats: De invloed van vezel en vet in de voeding op het ontstaan van kanker in de dikke darm bij ratten

Modulation of induced aberrant crypt foci (ACF) and colorectal cancer in azoxymethane-treated rats by novelose 330, cellulose and fat

Effect of dietary galacto-oligosaccharides on azoxymethane-induced aberrant crypt foci and colorectal cancer in Fischer 344 rats

The aim of the present study was to investigate the effects of galacto-oligosaccharides (GOS, Elix'or) on the development of aberrant crypt foci (ACF) and colorectal tumours in rats treated with azoxymethane (AOM). Two groups of 102 male Fischer 344 rats were injected twice with AOM to induce colorectal tumours, and fed diets containing either a...

Dietary fat and carcinogenesis

Epidemiologic investigations have suggested a relationship between dietary fat intake and various types of cancer incidences. Furthermore, epidemiologic studies as well as studies with animal models have demonstrated that not only the amount but also the type of fat consumed is important. At present, the mechanism by which dietary fat modulates...

A comparison of the effects of dietary cellulose and fermentable galacto-oligosaccharide, in a rat model of colorectal carcinogenesis: Fermentable fibre confers greater protection than non-fermentable fibre in both high and low fat background

The objective of this experiment was to compare the effects of diets with either a non-fermentable fibre source (cellulose) or a fermentable fibre source [galacto-oligosaccharide (GOS)], combined with different levels of dietary fat, on the development of colorectal cancer. Male Wistar rats were fed AIN76-based diets with either a low or high...

Safety evaluation of phytosterol esters. Part 3. Two-generation reproduction study in rats with phytosterol esters - A novel functional food

Phytosterol esters (PE) are intended for use as a novel food ingredient with plasma cholesterol lowering activity which works by inhibiting the absorption of cholesterol from the gut. Although PE are naturally present in the normal diet, the levels are insufficiently large to ensure lowering of plasma cholesterol levels. Therefore PE may be...

Safety evaluation of phytosterol esters, part 3: Two-generation reproduction study in rats with phytosterol esters - a novel functional food

Effect of saponin on the transmucosal passage of β-lactoglobulin across the proximal small intestine of normal and β-lactoglobulin-sensitised rats

The ability of saponins and glycoalkaloids to permeabilise the mammalian intestinal barrier has been previously demonstrated in vitro, leading to the hypothesis that membranolytic saponins may facilitate transfer to the tissues of otherwise excluded macromolecules. An enhanced uptake of, for instance, potentially allergenic species from the...

Nonneoplastic lesions of the hematopoietic system

Polymyopathy in a Syrian golden hamster

A Syrian golden hamster suffered from general swelling of skeletal muscles. At microscopical observation the muscle tissue exhibited degeneration and necrosis, as well as regenerative features. The inflammatory response was very slight. The histopathological lesions were diagnosed as polymyopathy.

Evaluatie basisnormering chemische belasting op de werkplek. Dl.1: prioritering van stoffen voor het vaststellen van wettelijke grenswaarden op basis van gezondheidskundige overwegingen

De grenswaarden in de eerste editie van de Nederlands MAC-lijst uit 1978 zijn bijna zonder uitzondering overgenomen van de TLV-lijst van de Amerikaanse ACGIH. Vanaf 1976 is de overheid begonnen met het ontwikkelen van "eigen" Nederlandse grenswaarden. De procedure voor het vaststellen van grenswaarden gaat echter langzaam. Het doel van het...