Alternative methods for internal quality control in research laboratories for environmental analysis: A programme for the performance evaluation of equipment, methods and staff

In analytical research laboratories, the problem of quality assurance is more difficult to solve than in laboratories devoted exclusively to routine analysis: the former usually have to deal with a much greater variety of samples and may have to develop entirely new methods of analysis. For research laboratories we have developed several...

Chemometrics in bioanalytical sample preparation: A fractionated combined mixture and factorial design for the modelling of the recovery of five tricyclic amines from plasma after liquid-liquid extraction prior to high-performance liquid chromatography

A general systematic approach is described for the chemometric modelling of liquid-liquid extraction data of drugs from biological fluids. Extraction solvents were selected from Snyder's solvent selectivity triangle; methyl tert.-butyl ether, methylene chloride and chloroform. The composition of a mixture of the three extraction solvents was...