High fat diet accelerates cartilage repair in DBA/1 mice

Obesity is a well-known risk factor for osteoarthritis, but it is unknown what it does on cartilage repair. Here we investigated whether a high fat diet (HFD) influences cartilage repair in a mouse model of cartilage repair. We fed DBA/1 mice control or HFD (60% energy from fat). After 2 weeks, a full thickness cartilage defect was made in the...

Lack of high BMI-related features in adipocytes and inflammatory cells in the infrapatellar fat pad (IFP)

Background. Obesity is associated with the development and progression of osteoarthritis (OA). Although the infrapatellar fat pad (IFP) could be involved in this association, due to its intracapsular localization in the knee joint, there is currently little known about the effect of obesity on the IFP. Therefore, we investigated cellular and...

Urban background noise mapping: The multiple-reflection correction term

Mapping of road traffic noise in urban areas according to standardized engineering calculation methods systematically results in an underestimation of noise levels at areas shielded from direct exposure to noise, such as inner yards. In most engineering methods, road traffic lanes are represented by point sources and noise levels are computed...

Urban background noise mapping: The general model

Surveys show that inhabitants of dwellings exposed to high noise levels benefit from having access to a quiet side. However, current practice in noise prediction often underestimates the noise levels at a shielded façade. Multiple reflections between façades in street canyons and inner yards are commonly neglected and façades are approximated as...

Statins and fibrates do not affect development of spontaneous cartilage damage in STR/Ort mice

Objective: Since statins and fibrates are capable of improving the metabolic profile of patients as well as decreasing inflammation, they are considered as potential drugs for preventing osteoarthritis (OA). The goal of the present study was to investigate the effect of these drugs in the STR/Ort spontaneous OA mouse model. Design: Male STR/Ort...

Improving the accuracy of engineering models at shielded building facades: Experimental analysis of turbulence scattering

Noise mapping models are able to accurately predict directly exposed facade levels near busy roads on condition that sufäciently detailed trafäc data is available. At the non-directly exposed side ofthe building, howeve¡ common practice application of standard methods strongly underpredicts sound pressure levels, potentially leading to an...

Stimulation of fibrotic processes by the infrapatellar fat pad in cultured synoviocytes from patients with osteoarthritis: a possible role for prostaglandin f2α

Objective: Stiffening of the joint is a feature of knee osteoarthritis (OA) that can be caused by fibrosis of the synovium. The infrapatellar fat pad (IPFP) present in the knee joint produces immune-modulatory and angiogenic factors. The goal of the present study was to investigate whether the IPFP can influence fibrotic processes in synovial...

On the improved point-to-point calculations for noise mapping in shielded urban areas

Noise mapping of urban areas according to standardized engineering calculation methods systematically results in an underestimation of noise levels at areas shielded from direct exposure to noise, such as inner yards. In these methods, road traffic lanes are represented by point sources and noise levels are computed utilizing point-to-point...

An efficient model for background noise mapping

It has been shown that inhabitants of dwellings exposed to high noise levels benefit from having access to a quiet side. Therefore the European Environmental Noise Directive allows member states to include the presence of a quiet side in their reports. However, current practice applications of noise mapping methods usually underestimate the...