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Bereszczak, J.Z. (author), Havlik, M. (author), Weiss, V.U. (author), Marchetti-Deschmann, M. (author), van Duijn, E. (author), Watts, N.R. (author), Wingfield, P.T. (author), Allmaier, G. (author), Steven, A.C. (author), Heck, A.J.R. (author)
The capsid of hepatitis B virus (HBV) is a major viral antigen and important diagnostic indicator. HBV capsids have prominent protrusions ('spikes') on their surface and are unique in having either T = 3 or T = 4 icosahedral symmetry. Mouse monoclonal and also human polyclonal antibodies bind either near the spike apices (historically the 'α...
article 2014
Bereszczak, J.Z. (author), Rose, R.J. (author), van Duijn, E. (author), Watts, N.R. (author), Wingfield, P.T. (author), Steven, A.C. (author), Heck, A.J.R. (author)
Infection of humans by hepatitis B virus (HBV) induces the copious production of antibodies directed against the capsid protein (Cp). A large variety of anticapsid antibodies have been identified that differ in their epitopes. These data, and the status of the capsid as a major clinical antigen, motivate studies to achieve a more detailed...
article 2013