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Fransman, W. (author), Arnone, M. (author), Borghi, F. (author), Cattaneo, A. (author), Cavallo, D.M. (author), Cherrie, J.W. (author), Franken, R. (author), Galea, K.S. (author), van der Haar, R. (author), Heussen, G.A.H. (author), Jensen, K.A. (author), Koponen, M. (author), Koppisch, D. (author), Kromhout, H. (author), Luo, KY.S. (author), McNally, K. (author), Säämänen, A. (author), Spinazzè, A. (author), van Tongeren, M. (author), Jeroen, (author), Vanoirbeek, J. (author), Verpaele, S. (author), Vetter, D. (author), Viegas, S. (author), Warren, N. (author)
In this article, we have responded to the key statements in the article by Koivisto et al. (2022) that were incorrect and considered to be a biased critique on a subset of the exposure models used in Europe (i.e. ART and Stoffenmanager®) used for regulatory exposure assessment. We welcome scientific discussions on exposure modelling (as was done...
article 2022
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McNally, K. (author), Goede, H.A. (author), Schinkel, J. (author), Gorce, J.P. (author), Warren, N. (author)
The dermal Advanced REACH Tool (dART) is a tier 2 exposure model for estimating dermal exposure to the hands (mg min-1) for non-volatile liquid and solid-in-liquid products. The dART builds upon the existing ART framework and describes three mass transport processes (deposition (Dhands), direct emission and direct contact (Ehands), and contact...
article 2022
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Ruiter, S. (author), Kuijpers, E. (author), Saunders, J. (author), Snawder, J. (author), Warren, N. (author), Gorce, J.P. (author), Blom, M. (author), Krone, T. (author), Bard, D. (author), Pronk, A. (author), Cauda, E. (author)
Background: Small, lightweight, low-cost optical particulate matter (PM) monitors are becoming popular in the field of occupational exposure monitoring, because these devices allow for real-time static measurements to be collected at multiple locations throughout a work site as well as being used as wearables providing personal exposure...
article 2020
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McNally, K. (author), Gorce, J.P. (author), Goede, H.A. (author), Schinkel, J. (author), Warren, N. (author)
The dermal Advanced REACH Tool (dART) is a Tier 2 exposure modelling tool currently in development for estimating dermal exposure to the hands (mg min-1) for non-volatile liquid and solids-in-liquid products. The dART builds upon the existing ART framework and describes three mass transport processes [deposition (Dhands), direct emission and...
article 2019
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Tan, E. (author), Boessen, R. (author), Fishwick, D. (author), Klein Entink, R. (author), Meijster, T. (author), Pronk, A. (author), van Duuren-Stuurman, B. (author), Warren, N. (author)
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease that is thought to affect over one million people in Great Britain. The main factor contributing to the development of COPD is tobacco smoke. This paper presents a microsimulation model for the development of COPD, incorporating population dynamics and trends in smoking. The...
article 2015
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McNally, K. (author), Warren, N. (author), Fransman, W. (author), Entink, R.K. (author), Schinkel, J. (author), Van Tongeren, M. (author), Cherrie, J.W. (author), Kromhout, H. (author), Schneider, T. (author), Tielemans, E. (author)
This paper describes a Bayesian model for the assessment of inhalation exposures in an occupational setting; the methodology underpins a freely available web-based application for exposure assessment, the Advanced REACH Tool (ART). The ART is a higher tier exposure tool that combines disparate sources of information within a Bayesian statistical...
article 2014
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Pronk, A. (author), Boessen, R. (author), Deurssen, E. (author), Meijster, T. (author), Klein Entink, R. (author), van Duuren-Stuurman, B. (author), Heederik, D. (author), Warren, N. (author), Tan, E. (author)
A multidimensional intervention study was performed to reduce personal quartz exposure in the Dutch construction industry (poster #0399). The intervention study focused on increasing the use of technical control measures (properly) among three high risk occupations by targeting organizational and behavioral factors The objective of this study...
public lecture 2014
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Schinkel, J. (author), Richie, P. (author), Goede, H. (author), Fransman, W. (author), van Tongeren, M. (author), Cherrie, J.W. (author), Tielemans, E. (author), Kromhout, H. (author), Warren, N. (author)
This article describes the structure, functionalities, and content of the Advanced REACH Tool (ART) exposure database (version 1.5). The incorporation of the exposure database into ART allows users who do not have their own measurement data for their exposure scenario, to update the exposure estimates produced by the mechanistic model using...
article 2013
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Marquart, H. (author), Schneider, T. (author), Goede, H. (author), Tischer, M. (author), Schinkel, J. (author), Warren, N. (author), Fransman, W. (author), Spaan, S. (author), van Tongeren, M. (author), Kromhout, H. (author), Tielemans, E. (author), Cherrie, J.W. (author), TNO Kwaliteit van Leven (author)
There is a large variety of activities in workplaces that can lead to emission of substances. Coding systems based on determinants of emission have so far not been developed. In this paper, a system of Activity Classes and Activity Subclasses is proposed for categorizing activities involving chemical use. Activity Classes share their so-called ...
article 2011
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Meijster, T. (author), Warren, N. (author), Heederik, D. (author), Tielemans, E. (author)
Rationale: Insight into the effectiveness of intervention strategies will help realise a decrease in the occupational disease burden from (allergic) respiratory diseases in the bakery population. Objectives: To use a simulation model to assess the impact of different intervention strategies on the disease burden of the bakery population over...
article 2011
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Schinkel, J. (author), Warren, N. (author), Fransman, W. (author), van Tongeren, M. (author), McDonnell, P. (author), Voogd, E. (author), Cherrie, J.W. (author), Tischer, M. (author), Kromhout, H. (author), Tielemans, E. (author)
The mechanistic model of the Advanced Reach Tool (ART) provides a relative ranking of exposure levels from different scenarios. The objectives of the calibration described in this paper are threefold: to study whether the mechanistic model scores are accurately ranked in relation to exposure measurements; to enable the mechanistic model to...
article 2011
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Meijster, T. (author), van Duuren-Stuurman, B. (author), Heederik, D. (author), Houba, R. (author), Koningsveld, E. (author), Warren, N. (author), Tielemans, E. (author)
Objectives: Use of cost-benefit analysis in occupational health increases insight into the intervention strategy that maximises the cost-benefit ratio. This study presents a methodological framework identifying the most important elements of a cost-benefit analysis for occupational health settings. One of the main aims of the methodology is to...
article 2011
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Meijster, T. (author), van Duuren-Stuurman, B. (author), Heederik, D. (author), Warren, N. (author), Houba, R. (author), Koningsveld, E. (author), Tielemans, E. (author)
Objectives Recently developed quantitative health impact assessment (HIA) methods provide insight into the impact of interventions on the population burden of disease. This information might subsequently be used in a cost-benefit analysis. In this study we developed a method that allocates costs and benefits across different stakeholders ...
article 2011
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Fransman, W. (author), van Tongeren, M. (author), Cherrie, J.W. (author), Tischer, M. (author), Schneider, T. (author), Schinkel, J. (author), Kromhout, H. (author), Warren, N. (author), Goede, H. (author), Tielemans, E. (author)
This paper describes the development of the mechanistic model within a collaborative project, referred to as the Advanced REACH Tool (ART) project, to develop a tool to model inhalation exposure for workers sharing similar operational conditions across different industries and locations in Europe. The ART mechanistic model is based on a...
article 2011
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Tielemans, E. (author), Warren, N. (author), Fransman, W. (author), van Tongeren, M. (author), McNally, K. (author), Tischer, M. (author), Ritchie, P. (author), Kromhout, H. (author), Schinkel, J. (author), Schneider, T. (author), Cherrie, J.W. (author), TNO Kwaliteit van Leven (author)
This paper provides an outline of the Advanced REACH Tool (ART) version 1.0 and a discussion of how it could be further developed. ART is a higher tier exposure assessment tool that combines mechanistically modelled inhalation exposure predictions with available exposure data using a Bayesian approach. ART assesses exposure for scenarios across...
article 2011
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van de Ven, P. (author), Fransman, W. (author), Schinkel, J. (author), Rubingh, C. (author), Warren, N. (author), Tielemans, E. (author), TNO Kwaliteit van Leven (author)
The web-based tool "Stoffenmanager" was initially developed to assist small- and medium-sized enterprises in the Netherlands to make qualitative risk assessments and to provide advice on control at the workplace. The tool uses a mechanistic model to arrive at a "Stoffenmanager score" for exposure. In a recent study it was shown that variability...
article 2010
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Spaan, S. (author), Fransman, W. (author), Warren, N. (author), Cotton, R. (author), Cocker, J. (author), Tielemans, E. (author), TNO Kwaliteit van Leven (author), KvL (author)
article 2010
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Warren, N. (author), Meijster, T. (author), Heederik, D. (author), Tielemans, E. (author), TNO Kwaliteit van Leven (author)
Objectives: This paper presents a dynamic population-based model for the development of sensitisation and respiratory symptoms in bakery workers. The model simulates a population of individual workers longitudinally and tracks the development of work-related sensitisation and respiratory symptoms in each worker. Methods: The model has three...
article 2009
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Meijster, T. (author), Warren, N. (author), Heederik, D. (author), Tielemans, E. (author), TNO Kwaliteit van Leven (author)
Recently a dynamic population model was developed that simulates a population of bakery workers longitudinally through time and tracks the development of work-related sensitisation and respiratory symptoms in each worker. Input for this model comes from cross-sectional and longitudinal epidemiological studies which allowed estimation of exposure...
article 2009
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Tielemans, E. (author), Schneider, T. (author), Goede, H. (author), Tischer, M. (author), Warren, N. (author), Kromhout, H. (author), van Tongeren, M. (author), van Hemmen, J. (author), Cherrie, J.W. (author), TNO Kwaliteit van Leven (author)
The present paper proposes a source-receptor model to schematically describe inhalation exposure to help understand the complex processes leading to inhalation of hazardous substances. The model considers a stepwise transfer of a contaminant from the source to the receptor. The conceptual model is constructed using three components, i.e. (i) the...
article 2008
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