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van der Greef, J. (author), van Wietmarschen, H. (author), Schroën, J. (author), Wang, M. (author), Hankemeier, T. (author), Xu, G. (author), TNO Kwaliteit van Leven (author)Innovative systems approaches to develop medicine and health care are emerging from the integration of Chinese and Western medicine strategies, philosophies and practices. The two medical systems are highly complementary as the reductionist aspects of Western medicine are favourable in acute disease situations and the holistic aspects of Chinese...article 2010
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van Wietmarschen, H. (author), Yuan, K. (author), Lu, C. (author), Gao, P. (author), Wang, J. (author), Xiao, C. (author), Yan, X. (author), Wang, M. (author), Schroën, J. (author), Lu, A. (author), Xu, G. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)BACKGROUND: Complex chronic diseases such as rheumatoid arthritis have become a major challenge in medicine and for the pharmaceutical industry. New impulses for drug development are needed. OBJECTIVE: A systems biology approach is explored to find subtypes of rheumatoid arthritis patients enabling a development towards more personalized...article 2009
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Hu, C. (author), van der Heijden, R. (author), Wang, M. (author), van der Greef, J. (author), Hankemeier, T. (author), Xu, G. (author), TNO Kwaliteit van Leven (author)Lipidomics is a lipid-targeted metabolomics approach aiming at comprehensive analysis of lipids in biological systems. Recently, lipid profiling, or so-called lipidomics research, has captured increased attention due to the well-recognized roles of lipids in numerous human diseases to which lipid-associated disorders contribute, such as diabetes...article 2009
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Wang, J. (author), Reijmers, T. (author), Chen, L. (author), van der Heijden, R. (author), Wang, M. (author), Peng, S. (author), Hankemeier, T. (author), Xu, G. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)A metabolomics-based systems toxicology approach was used to profile the urinary metabolites for the toxicity related processes and pathogenesis induced by doxorubicin (DOX) to rats. Endogenous metabolite profiles were obtained with ultra performance liquid chromatography-mass spectrometry (UPLC-MS) for rats receiving different single dosages of...article 2009
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Kong, H. (author), Wang, M. (author), Venema, K. (author), Maathuis, A. (author), van der Heijden, R. (author), van der Greef, J. (author), Xu, G. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)A high-performance liquid chromatography-high resolution Fourier transform ion cyclotron resonance mass spectrometry (HPLC-FTICR-MS) method was developed to investigate the metabolism of ginsenosides in in vitro models of the gastro-intestinal tract. The metabolites were identified by high-resolution tandem mass spectrometry. Degradation and...article 2009
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Wang, J. (author), van der Heijden, R. (author), Spruit, S. (author), Hankermeier, T. (author), Chan, K. (author), van der Greef, J. (author), Xu, G. (author), Wang, M. (author), TNO Kwaliteit van Leven (author)Chinese herbal medicines, often referred as Chinese materia medica (CMM), are comprised of a complex multicomponent nature. The activities are aimed at the system level via interactions with a multitude of targets in the human body. This review aims at the toxicity aspects of CMM and its preparations at the different steps of production;...article 2009
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Wang, J. (author), van der Heijden, R. (author), Spijksma, G. (author), Reijmers, T. (author), Wang, M. (author), Xu, G. (author), Hankemeier, T. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)A matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) method was developed for the high throughput and robust qualitative profiling of alkaloids in Fuzi-the processed lateral roots of the Chinese herbal medicine Aconitum carmichaeli Debx (A. carmichaeli). After optimization, powdered roots - without any further sample...article 2009
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- Hu, C. (author), van Dommelen, J. (author), van der Heijden, R. (author), Spijksma, G. (author), Reijmers, T.H. (author), Wang, M. (author), Slee, E. (author), Lu, X. (author), Xu, G. (author), van der Greef, J. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author) article 2008
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Angelova, N. (author), Kong, H.-W. (author), van de Heijden, R. (author), Yang, S.-Y. (author), Choi, Y.H. (author), Kim, H.K. (author), Wang, M. (author), Hankemeier, T. (author), van der Greef, J. (author), Xu, G. (author), Verpoorte, R. (author), TNO Kwaliteit van Leven (author)This review summarises the most recent developments in ginseng analysis, in particular the novel approaches in sample pre-treatment and the use of high-performance liquid-chromatography-mass spectrometry. The review also presents novel data on analysing ginseng extracts by nuclear magnetic resonance spectroscopy and high-resolution mass...article 2008
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Hu, C. (author), van Dommelen, J. (author), van der Heijden, R. (author), Spijksma, G. (author), Reijmers, T.H. (author), Wang, M. (author), Slee, E. (author), Lu, X. (author), Xu, G. (author), van der Greef, J. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)A reversed-phase liquid chromatography-linear ion trap-Fourier transform ion cyclotron resonance-mass spectrometry method was developed for the profiling of lipids in human and mouse plasma. With the use of a fused-core C<sub>8</sub> column and a binary gradient, more than 160 lipids belonging to eight different classes were detected in a single...article 2008
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Agalou, A. (author), Purwantomo, S. (author), Övernäs, E. (author), Johannesson, H. (author), Zhu, X. (author), Estiati, A. (author), de Kam, R.J. (author), Engström, P. (author), Slamet-Loedin, I.H. (author), Zhu, Z. (author), Wang, M. (author), Xiong, L. (author), Meijer, A.H. (author), Ouwerkerk, P.B.F. (author), TNO Kwaliteit van Leven (author)The homeodomain leucine zipper (HD-Zip) genes encode transcription factors that have diverse functions in plant development and have often been implicated in stress adaptation. The HD-Zip genes are the most abundant group of homeobox (HB) genes in plants and do not occur in other eukaryotes. This paper describes the complete annotation of the HD...article 2008
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Wang, Y. (author), Xiao, Y. (author), Zhang, Y. (author), Chai, C. (author), Wei, G. (author), Wei, X. (author), Xu, H. (author), Wang, M. (author), Ouwerkerk, P.B.F. (author), Zhu, Z. (author), TNO Kwaliteit van Leven (author)Monosaccharides transporters play important roles in assimilate supply for sink tissue development. In this study, a new monosaccharide transporter gene OsMST6 was identified from rice (Oryza sativa L.). The predicted OsMST6 protein shows typical features of sugar transporters and shares 79.6% identity with the rice monosaccharide transporter...article 2008
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Wang, Y. (author), Xu, H. (author), Wei, X. (author), Chai, C. (author), Xiao, Y. (author), Zhang, Y. (author), Chen, B. (author), Xiao, G. (author), Ouwerkerk, P.B.F. (author), Wang, M. (author), Zhu, Z. (author), TNO Kwaliteit van Leven (author)Monosaccharide transporters mediate the membrane transport of a variable range of monosaccharides, which plays a crucial role in sugar distribution throughout the plant. To investigate the significance of monosaccharide transporters for rice (Oryza sativa L.) seed development, cDNA of a new putative monosaccharide transporter gene OsMST4 was...article 2007
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Verhoeckx, K.C.M. (author), Korthout, H.A.A.J. (author), van Meeteren-Kreikamp, A.P. (author), Ehlert, K.A. (author), Wang, M. (author), van der Greef, J. (author), Rodenburg, R.J.T. (author), Witkamp, R.F. (author), TNO Kwaliteit van Leven (author)There is a great interest in the pharmacological properties of cannabinoid like compounds that are not linked to the adverse effects of Δ9-tetrahydrocannabinol (THC), e.g. psychoactive properties. The present paper describes the potential immuno-modulating activity of unheated Cannabis sativa extracts and its main non-psychoactive constituent Δ9...article 2006
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Maraschin, S.D.F. (author), Caspers, M. (author), Potokina, E. (author), Wülfert, F. (author), Graner, A. (author), Spaink, H.P. (author), Wang, M. (author), TNO Kwaliteit van Leven (author)Different aspects of androgenesis induction have been studied in detail, but little is known about the molecular mechanisms associated with this developmental switch. We have employed macroarrays containing 1421 expressed sequence tags covering the early stages of barley zygotic embryogenesis to compare the gene expression profiles of stress...article 2006
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Chang, W.T. (author), Thissen, U. (author), Ehlert, K.A. (author), Koek, M.M. (author), Jellema, R.H. (author), Hankemeier, T. (author), van der Greef, J. (author), Wang, M. (author), TNO Kwaliteit van Leven TNO Voeding (author)Metabolite profiling in combination with multivariate statistics is a sophisticated method for quality assessment of natural products. For the development of a quality control strategy in Traditional Chinese Medicine (TCM), we have measured the metabolite fingerprints of Rehmannia glutinosa by GC-MS. Plants were grown under different climate and...article 2006
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Primo-Martín, C. (author), Wang, M. (author), Lichtendonk, W.J. (author), Plijter, J.J. (author), Hamer, R.J. (author), TNO Kwaliteit van Leven (author)In the bakery industry, glucose oxidase is usually used in combination with xylanase. Although many theories exist on the mechanism of action of each enzyme, the positive effect of combining the two is as yet unexplained. In this paper we studied a possible basis for this synergy by focusing on the involvement of arabinoxylans. Water-extractable...article 2005
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Interaction of water unextractable solids and xylanase with gluten protein: Effect of wheat cultivarWang, M. (author), van Vliet, T. (author), Hamer, R.J. (author), TNO Voeding (author)A previously proposed explanation for the change in gluten properties on addition of pentosans to doughs was based on data for only one wheat cultivar. Using three wheat cultivars, Scipion, Soissons and Amazon, differing in technological quality from weak to strong we have obtained results that support the previous explanation. In addition to...article 2005
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Maraschin, S.F. (author), de Priester, W. (author), Spaink, H.P. (author), Wang, M. (author)Embryogenesis in plants is a unique process in the sense that it can be initiated from a wide range of cells other than the zygote. Upon stress, microspores or young pollen grains can be switched from their normal pollen development towards an embryogenic pathway, a process called androgenesis. Androgenesis represents an important tool for...article 2005
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Time-lapse tracking of barley androgenesis reveals position-determined cell death within pro-embryosMaraschin, S.D.F. (author), Vennik, M. (author), Lamers, G.E.M. (author), Spaink, H.P. (author), Wang, M. (author)Following abiotic stress to induce barley (Hordeum vulgare L.) androgenesis, the development of 794 enlarged microspores in culture was monitored by time-lapse tracking. In total, 11% of the microspores tracked developed into embryo-like structures (type-I pathway), 36% formed multicellular structures (type-II pathway) and 53% of the microspores...article 2005