- document
- Liping, Qu (author), Wenjun, Zou (author), Zhenxiang, Zhou (author), Tingmo, Zhang (author), van der Greef, J. (author), Wang, M. (author) article 2014
- document
-
Eeftens, M. (author), Hoek, G. (author), Gruzieva, O. (author), Mölter, A. (author), Agius, R. (author), Beelen, R. (author), Brunekreef, B. (author), Custovic, A. (author), Cyrys, J. (author), Fuertes, E. (author), Heinrich, J. (author), Hoffmann, B. (author), De Hoogh, K. (author), Jedynska, A. (author), Keuken, M. (author), Klümper, C. (author), Kooter, I. (author), Krämer, U. (author), Korek, M. (author), Koppelman, G.H. (author), Kuhlbusch, T.A.J. (author), Simpson, A. (author), Smit, H.A. (author), Tsai, M.Y. (author), Wang, M. (author), Wolf, K. (author), Pershagen, G. (author), Gehring, U. (author)BACKGROUND: Negative effects of long-term exposure to particulate matter (PM) on lung function have been shown repeatedly. Spatial differences in the composition and toxicity of PM may explain differences in observed effect sizes between studies. METHODS: We conducted a multicenter study in 5 European birth cohorts - BAMSE (Sweden), GINIplus and...article 2014
- document
-
Fuertes, E. (author), MacIntyre, E. (author), Agius, R. (author), Beelen, R. (author), Brunekreef, B. (author), Bucci, S. (author), Cesaroni, G. (author), Cirach, M. (author), Cyrys, J. (author), Forastiere, F. (author), Gehring, U. (author), Gruzieva, O. (author), Hoffmann, B. (author), Jedynska, A. (author), Keuken, M. (author), Klümper, C. (author), Kooter, I. (author), Korek, M. (author), Krämer, U. (author), Mölter, A. (author), Nieuwenhuijsen, M. (author), Pershagen, G. (author), Porta, D. (author), Postma, D.S. (author), Simpson, A. (author), Smit, H.A. (author), Sugiri, D. (author), Sunyer, J. (author), Wang, M. (author), Heinrich, J. (author)Evidence for a role of long-term particulate matter exposure on acute respiratory infections is growing. However, which components of particulate matter may be causative remains largely unknown. We assessed associations between eight particulate matter elements and early-life pneumonia in seven birth cohort studies (Ntotal=15,980): BAMSE (Sweden...article 2014
- document
-
Chen, Y. (author), Sun, A. (author), Wang, M. (author), Zhu, Z. (author), Ouwerkerk, P.B.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Glutelins are the most abundant storage proteins in rice grain and can make up to 80 % of total protein content. The promoter region of GluB-1, one of the glutelin genes in rice, has been intensively used as a model to understand regulation of seed-storage protein accumulation. In this study, we describe a zinc finger gene of the Cys3His1 (CCCH...article 2014
- document
-
Genkinger, J.M. (author), Wang, M. (author), Li, R. (author), Albanes, D. (author), Anderson, K.E. (author), Bernstein, L. (author), van den Brandt, P.A. (author), English, D.R. (author), Freudenheim, J.L. (author), Fuchs, C.S. (author), Gapstur, S.M. (author), Giles, G.G. (author), Goldbohm, R.A. (author), Håkansson, N. (author), Horn-Ross, P.L. (author), Koushik, A. (author), Marshal, J.R. (author), McCullough, M.L. (author), Miller, A.B. (author), Robien, K. (author), Rohan, T.E. (author), Schairer, C. (author), Silverman, D.T. (author), Stolzenberg-Solomon, R.Z. (author), Virtamo, J. (author), Willett, W.C. (author), Wolk, A. (author), Ziegler, R.G. (author), Smith-Warner, S.A. (author)Pancreatic cancer has few early symptoms, is usually diagnosed at late stages, and has a high case-fatality rate. Identifying modifiable risk factors is crucial to reducing pancreatic cancer morbidity and mortality. Prior studies have suggested that specific foods and nutrients, such as dairy products and constituents, may play a role in...article 2014
- document
-
Xiao, Y. (author), Chen, Y. (author), Charnikhova, T. (author), Mulder, P.P.J. (author), Heijmans, J. (author), Hoogenboom, A. (author), Agalou, A. (author), Michel, C. (author), Morel, J.B. (author), Dreni, L. (author), Kater, M.M. (author), Bouwmeester, H. (author), Wang, M. (author), Zhu, Z. (author), Ouwerkerk, P.B.F. (author)Jasmonates are important phytohormones regulating reproductive development. We used two recessive rice Tos17 alleles of OsJAR1, osjar1-2 and osjar1-3, to study the biological function of jasmonates in rice anthesis. The florets of both osjar1 alleles stayed open during anthesis because the lodicules, which control flower opening in rice, were...article 2014
- document
- Schroën, Y. (author), van Wietmarschen, H.A. (author), Wang, M. (author), van Wijk, E.P. (author), Hankemeier, T. (author), Xu, G. (author), van der Greef, J. (author) article 2014
- document
-
Hegyi, A. (author), Netten, B.D. (author), Wang, M. (author), Schakel, W. (author), Schreiter, T. (author), Yuan, Y. (author), van Arem, B. (author), Alkim, T. (author)The SPECIALIST algorithm can resolve jam waves on freeways using roadside technology: detector loops and speed limit gantries. In this paper we extend the algorithm, enabling the integration with cooperative system technologies and other road side detectors, such as in-car detection and actuation, and video-based monitoring (VBM). Integrating...conference paper 2013
- document
-
Netten, B.D. (author), Hegyi, A. (author), Wang, M. (author), Schakel, W. (author), Yuan, Y. (author), Schreiter, T. (author), van Arem, B. (author), van Leeuwen, C.J. (author), Alkim, T. (author)Dynamax is a road side based system using the SPECIALIST control algorithm and inductive loops. Dynamax field tests showed that moving jams can be effectively resolved by dynamic speed measures [1,5]. This paper focuses on Dynamax In Car, which extends the road side infrastructure with a V2I cooperative approach. V2I cooperation is used to...conference paper 2013
- document
-
van Wietmarschen, H.A. (author), der Greef, J.V. (author), Schroën, Y. (author), Wang, M. (author)Ethnopharmacological relevance Rehmannia Six Formula (R6, Chinese name is Liu Wei Di Huang Wan) is one of the most important classic Chinese medicine formula used to treat metabolic disorders related to aging. It was first reported in the Chinese medicine book titled 'Xiao Er Yao Zheng Zhi Jue by Qian Yi' (Chinese Song dynasty: 1035-1117). In...article 2013
- document
-
Zhu, C. (author), Dane, A. (author), Spijksma, G. (author), Wang, M. (author), van der Greef, J. (author), Luo, G. (author), Hankemeier, T. (author), Vreeken, R.J. (author)A hydrophilic interaction liquid chromatography (HILIC) - ion trap mass spectrometry method was developed for separation of a wide range of phospholipids. A diol column which is often used with normal phase chromatography was adapted to separate different phospholipid classes in HILIC mode using a mobile phase system consisting of acetonitrile,...article 2012
- document
-
Wei, H. (author), Pasman, W. (author), Rubingh, C. (author), Wopereis, S. (author), Tienstra, M. (author), Schroen, J. (author), Wang, M. (author), Verheij, E. (author), van der Greef, J. (author)The prevalence of type 2 diabetes continuously increases globally. A personalized strategy applied in the pre-diabetic stage is vital for diabetic prevention and management. The personalized diagnosis of Chinese Medicine (CM) may help to stratify the diabetics. Metabolomics is regarded as a potential platform to provide biomarkers for disease...article 2012
- document
-
van Wietmarschen, H.A. (author), Dai, W. (author), van der Kooij, A.J. (author), Reijmers, T.H. (author), Schroën, Y. (author), Wang, M. (author), Xu, Z. (author), Wang, X. (author), Kong, H. (author), Xu, G. (author), Hankemeier, T. (author), Meulman, J.J. (author), van der Greef, J. (author)Objective: The aim is to characterize subgroups or phenotypes of rheumatoid arthritis (RA) patients using a systems biology approach. The discovery of subtypes of rheumatoid arthritis patients is an essential research area for the improvement of response to therapy and the development of personalized medicine strategies. Methods: In this study,...article 2012
- document
-
Wei, H. (author), Hu, C. (author), Wang, M. (author), van den Hoek, A.M. (author), Reijmers, T.H. (author), Wopereis, S. (author), Bouwman, J. (author), Ramaker, R. (author), Korthout, H.A.A.J. (author), Vennik, M. (author), Hankemeier, T. (author), Havekes, L.M. (author), Witkamp, R.F. (author), Verheij, E.R. (author), Xu, G. (author), van der Greef, J. (author)Background: Causes and consequences of the complex changes in lipids occurring in the metabolic syndrome are only partly understood. Several interconnected processes are deteriorating, which implies that multi-target approaches might be more successful than strategies based on a limited number of surrogate markers. Preparations from Chinese...article 2012
- document
-
Hu, C. (author), Wei, H. (author), Kong, H. (author), Bouwman, J. (author), Gonzalez-Covarrubias, V. (author), van der Heijden, R. (author), Reijmers, T.H. (author), Bao, X. (author), Verheij, E.R. (author), Hankemeier, T. (author), Xu, G. (author), van der Greef, J. (author), Wang, M. (author)Although a number of animal experiments and clinical trials have investigated the effects of ginseng roots on diabetes, the relationship between their therapeutic effects on diabetes and the quality and the growth age of this herb have not yet been reported. This study systematically investigated the effects of 3- to 6-year-old ginseng roots on...article 2011
- document
-
Chang, W.T. (author), Choi, Y.H. (author), van der Heijden, R. (author), Lee, M.S. (author), Lin, M.K. (author), Kong, H. (author), Kim, H.K. (author), Verpoorte, R. (author), Hankemeier, T. (author), van der Greef, J. (author), Wang, M. (author)The processing of biological raw materials is considered to have an important role in the therapeutic application in Traditional Chinese Medicine. The root of Rehmannia glutinosa has to be processed by nine cycles of rice wine immersing, steaming and drying before using in clinical applications. In order to understand the chemical changes...article 2011
- document
-
Sun, A. (author), Dai, Y. (author), Zhang, X. (author), Li, C. (author), Meng, K. (author), Xu, H. (author), Wei, X. (author), Xiao, G. (author), Ouwerkerk, P.B. (author), Wang, M. (author), Zhu, Z. (author)In many plants, sucrose transporters are essential for both sucrose exports from sources and imports into sinks, indicating a function in assimilate partitioning. To investigate whether sucrose transporters can improve the yield of starch plant, potato plants (Solanum tuberosum L. cv. Désirée) were transformed with cDNAs of the rice sucrose...article 2011
- document
-
Hu, C. (author), Kong, H. (author), Zhu, C. (author), Wei, H. (author), Hankemeier, T. (author), van der Greef, J. (author), Wang, M. (author), Xu, G. (author)A method for fast analysis of ginsenosides in Panax ginseng roots was developed using ultra performance liquid chromatography-time-of-flight-mass spectrometry (UPLC-TOF-MS). The column used was HSS T3 (100 mm × 2.1 mm, 1.8 µm). The mobile phase consisted of 15 mmol/L ammonium formate and acetonitrile, eluted with the gradient program. The...article 2011
- document
-
Hu, C. (author), Wei, H. (author), van den Hoek, A.M. (author), Wang, M. (author), van der Heijden, R. (author), Spijksma, G. (author), Reijmers, T.H. (author), Bouwman, J. (author), Wopereis, S. (author), Havekes, L.M. (author), Verheij, E. (author), Hankemeier, T. (author), Xu, G. (author), van der Greef, J. (author)Background: Lipids are known to play crucial roles in the development of life-style related risk factors such as obesity, dyslipoproteinemia, hypertension and diabetes. The first selective cannabinoid-1 receptor blocker rimonabant, an anorectic anti-obesity drug, was frequently used in conjunction with diet and exercise for patients with a body...article 2011
- document
-
Song, G.S. (author), Zhai, H.L. (author), Peng, Y.G. (author), Zhang, L. (author), Wei, G. (author), Chen, X.Y. (author), Xiao, Y.G. (author), Wang, L. (author), Chen, Y.J. (author), Wu, B. (author), Chen, B. (author), Zhang, Y. (author), Chen, H. (author), Feng, X.J. (author), Gong, W.K. (author), Liu, Y. (author), Yin, Z.J. (author), Wang, F. (author), Liu, G.Z. (author), Xu, H.L. (author), Wei, X.L. (author), Zhao, X.L. (author), Ouwerkerk, P.B.F. (author), Hankemeier, T. (author), Reijmers, T. (author), van der Heijden, R. (author), Lu, C.M. (author), Wang, M. (author), van der Greef, J. (author), Zhu, Z. (author), TNO Kwaliteit van Leven (author)Heterosis is a biological phenomenon whereby the offspring from two parents show improved and superior performance than either inbred parental lines. Hybrid rice is one of the most successful apotheoses in crops utilizing heterosis. Transcriptional profiling of F1 super-hybrid rice Liangyou-2186 and its parents by serial analysis of gene...article 2010