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Knoop, V.L. (author), Wang, M. (author), Wilmink, I. (author), Hoedemaeker, D.M. (author), Maaskant, M. (author), van der Meer, E.J. (author)An increasing amount of vehicles are equipped with driver assistance systems; many of the vehicles currently on the market can be optionally equipped with adaptive cruise control and lane centering systems. Using both systems at the same time brings the vehicle to SAE level-2 automation. This means a driver does not need to perform longitudinal...article 2019
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He, M. (author), Harms, A.C. (author), van Wijk, E. (author), Wang, M. (author), Berger, R. (author), Koval. S., (author), Hankemeier, T. (author), van der Greef, J. (author)Background. Rheumatoid arthritis (RA) is a complex, chronic autoimmune disease characterized by various inflammatory symptoms, including joint swelling, joint pain, and both structural and functional joint damage. The most commonly used animal model for studying RA is mice with collagen‐induced arthritis (CIA); the wide use of this model is due...article 2019
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Weinmayr, G. (author), Pedersen, M. (author), Stafoggia, M. (author), Andersen, Z.J. (author), Galassi, C. (author), Munkenast, J. (author), Jaensch, A. (author), Oftedal, B. (author), Krog, N.H. (author), Aamodt, G. (author), Pyko, A. (author), Pershagen, G. (author), Korek, M. (author), de Faire, U. (author), Pedersen, N.L. (author), Ostenson, C.G. (author), Rizzuto, D. (author), Sørensen, M. (author), Tjønneland, A. (author), Bueno-de-Mesquita, B. (author), Vermeulen, R. (author), Eeftens, M. (author), Concin, H. (author), Lang, A. (author), Wang, M. (author), Tsai, M.Y. (author), Ricceri, F. (author), Sacerdote, C. (author), Ranzi, A. (author), Cesaroni, G. (author), Forastiere, F. (author), de Hoogh, K. (author), Beelen, R. (author), Vineis, P. (author), Kooter, I. (author), Sokhi, R. (author), Brunekreef, B. (author), Hoek, G. (author), Raaschou-Nielsen, O. (author), Nagel, G. (author)Introduction: Previous analysis from the large European multicentre ESCAPE study showed an association of ambient particulate matter <2.5 μm (PM2.5) air pollution exposure at residence with the incidence of gastric cancer. It is unclear which components of PM are most relevant for gastric and also upper aerodigestive tract (UADT) cancer and some...article 2018
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Andersen, Z.J. (author), Pedersen, M. (author), Weinmayr, G. (author), Stafoggia, M. (author), Galassi, C. (author), Jørgensen, J.T. (author), Sommar, J.N. (author), Forsberg, B. (author), Olsson, D. (author), Oftedal, B. (author), Aasvang, G.M. (author), Schwarze, P. (author), Pyko, A. (author), Pershagen, G. (author), Korek, M. (author), Faire, U.D. (author), Östenson, C.G. (author), Fratiglioni, L. (author), Eriksen, K.T. (author), Poulsen, A.H. (author), Tjønneland, A. (author), Braüner, E.V. (author), Peeters, P.H. (author), Bueno de Mesquita, B. (author), Jaensch, A. (author), Nagel, G. (author), Lang, A. (author), Wang, M. (author), Tsai, M.Y. (author), Grioni, S. (author), Marcon, A. (author), Krogh, V. (author), Ricceri, F. (author), Sacerdote, C. (author), Migliore, E. (author), Vermeulen, R. (author), Sokhi, R. (author), Keuken, M. (author), de Hoogh, K. (author), Beelen, R. (author), Vineis, P. (author), Cesaroni, G. (author), Brunekreef, B. (author), Hoek, G. (author), Raaschou-Nielsen, O. (author)Background. Epidemiological evidence on the association between ambient air pollution and brain tumor risk is sparse and inconsistent. Methods. In 12 cohorts from 6 European countries, individual estimates of annual mean air pollution levels at the baseline residence were estimated by standardized land-use regression models developed within the...article 2018
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Sun, M. (author), Chang, W.T. (author), van Wijk, E. (author), He, M. (author), Koval, S. (author), Lin, M.K. (author), Van Wijk, R. (author), Hankemeier, T. (author), van der Greef, J. (author), Wang, M. (author)Based on the traditional Chinese medicine theory, the Chinese pharmacopeia assigns a therapeutic description of “taste” to all herbs; thus, an herb's “taste” is valued in traditional Chinese medicine as a major ethnopharmacological category and reflects the herb's therapeutic properties. These properties guide the practitioner with respect to...article 2017
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Jedynska, A. (author), Hoek, G. (author), Wang, M. (author), Yang, A. (author), Eeftens, M. (author), Cyrys, J. (author), Keuken, M. (author), Ampe, C. (author), Beelen, R. (author), Cesaroni, G. (author), Forastiere, F. (author), Cirach, M. (author), de Hoogh, K. (author), de Nazelle, A. (author), Nystad, W. (author), Akhlaghi, H.M. (author), Declercq, C. (author), Stempfelet, M. (author), Eriksen, K.T. (author), Dimakopoulou, K. (author), Lanki, T. (author), Meliefste, K. (author), Nieuwenhuijsen, M. (author), Yli-Tuomi, T. (author), Raaschou-Nielsen, O. (author), Janssen, N.A.H. (author), Brunekreef, B. (author), Kooter, I.M. (author)Oxidative potential (OP) has been suggested as a health-relevant measure of air pollution. Little information is available about OP spatial variation and the possibility to model its spatial variability. Our aim was to measure the spatial variation of OP within and between 10 European study areas. The second aim was to develop land use...article 2017
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Sun, M. (author), van Wijk, E. (author), Koval, S. (author), van Wijk, R. (author), He, M. (author), Wang, M. (author), Hankemeier, T. (author), van der Greef, J. (author)The global prevalence of type 2 diabetes is estimated to reach 4.4% by 2030, placing a significant burden on our healthcare system. Therefore, the ability to identify patients in early stages of the disease is essential for both prevention and effective management, and diagnostic methods based on traditional Chinese medicine (TCM) may be...article 2017
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He, M. (author), van Wijk, E. (author), van Wietmarschen, H. (author), Wang, M. (author), Sun, M. (author), Koval, S. (author), van Wijk, R. (author), Hankemeier, T. (author), van der Greef, J. (author)The increasing prevalence of rheumatoid arthritis has driven the development of new approaches and technologies for investigating the pathophysiology of this devastating, chronic disease. From the perspective of systems biology, combining comprehensive personal data such as metabolomics profiling with ultra-weak photon emission (UPE) data may...article 2017
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Andersen, Z.J. (author), Stafoggia, M. (author), Weinmayr, G. (author), Pedersen, M. (author), Galassi, C. (author), Jørgensen, J.T. (author), Oudin, A. (author), Forsberg, B. (author), Olsson, D. (author), Oftedal, B. (author), Aasvang, G.M. (author), Aamodt, G. (author), Pyko, A. (author), Pershagen, G. (author), Korek, M. (author), de Faire, U. (author), Pedersen, N.L. (author), Östenson, C.G. (author), Fratiglioni, L. (author), Eriksen, K.T. (author), Tjønneland, A. (author), Peeters, P.H. (author), Bueno de Mesquita, B. (author), Plusquin, M. (author), Key, T.J. (author), Jaensch, A. (author), Nagel, G. (author), Lang, A. (author), Wang, M. (author), Tsai, M.Y. (author), Fournier, A. (author), Boutron-Ruault, M.C. (author), Baglietto, L. (author), Grioni, S. (author), Marcon, A. (author), Krogh, V. (author), Ricceri, F. (author), Sacerdote, C. (author), Migliore, E. (author), Tamayo-Uria, I. (author), Amiano, P. (author), Dorronsoro, M. (author), Vermeulen, R. (author), Sokhi, R. (author), Keuken, M. (author), de Hoogh, K. (author), Beelen, R. (author), Vineis, P. (author), Cesaroni, G. (author), Brunekreef, B. (author), Hoek, G. (author), Raaschou-Nielsen, O. (author)BACKGROUND: Epidemiological evidence on the association between ambient air pollution and breast cancer risk is inconsistent. OBJECTIVE: We examined the association between long-term exposure to ambient air pollution and incidence of postmenopausal breast cancer in European women. METHODS: In 15 cohorts from nine European countries, individual...article 2017
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Sun, M. (author), van Wijk, R. (author), van Wijk, E. (author), Wang, M. (author), van Wietmarschen, H. (author), Hankemeier, T. (author), van der Greef, J. (author)In Chinese medicine, raw herbal materials are used in processed and unprocessed forms aiming to meet the different requirements of clinical practice. To assure the chemical quality and therapeutic properties of the herbs, fast and integrated systematic assays are required. So far, such assays have not been established. Delayed luminescence (DL)...article 2016
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Pedersen, M. (author), Gehring, U. (author), Beelen, R. (author), Wang, M. (author), Giorgis-Allemand, L. (author), Andersen, A.M.N. (author), Basagaña, X. (author), Bernard, C. (author), Cirach, M. (author), Forastiere, F. (author), de Hoogh, K. (author), Gražuleviĉvienė, R. (author), Gruzieva, O. (author), Hoek, G. (author), Jedynska, A. (author), Klümper, C. (author), Kooter, I.M. (author), Krämer, U. (author), Kukkonen, J. (author), Porta, D. (author), Postma, D.S. (author), Raaschou-Nielsen, O. (author), van Rossem, L. (author), Sunyer, J. (author), Sørensen, M. (author), Tsai, M.Y. (author), Vrijkotte, T.G.M. (author), Wilhelm, M. (author), Nieuwenhuijsen, M.J. (author), Pershagen, G. (author), Brunekreef, B. (author), Kogevinas, M. (author), Slama, R. (author)Background: The health effects of suspended particulate matter (PM) may depend on its chemical composition. Associations between maternal exposure to chemical constituents of PM and newborn’s size have been little examined. Objective: We aimed to investigate the associations of exposure to elemental constituents of PM with term low birth weight ...article 2016
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Chen, Y. (author), Miller, A.J. (author), Luo, B. (author), Wang, M. (author), Zhu, Z. (author), Ouwerkerk, P.B.F. (author)Previously we showed in the osjar1 mutants that the lodicule senescence which controls the closing of rice flowers was delayed. This resulted in florets staying open longer when compared with the wild type. The gene OsJAR1 is silenced in osjar1 mutants and is a key member of the jasmonic acid (JA) signaling pathway. We found that K...article 2016
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Sun, M. (author), Li, L. (author), Wang, M. (author), Van Wijk, E. (author), He, M. (author), van Wijk, R. (author), Koval, S. (author), Hankemeier, T. (author), van der Greef, J. (author), Wei, S. (author)To improve the quality control of herbal drugs, there has been a major shift from evaluating individual chemicals to evaluating multiple-constituent chemicals, given the multi-pharmacology nature of herbal drugs. Therefore, rapid, systematic assays are needed in order to assess the quality of medicinal herbs using a comprehensive, integrated...article 2016
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He, M. (author), Sun, M. (author), van Wijk, E. (author), van Wietmarschen, H. (author), van Wijk, R. (author), Wang, Z. (author), Wang, M. (author), Hankemeier, T. (author), van der Greef, J. (author)To present the possibilities pertaining to linking ultra-weak photon emission (UPE) with Chinese medicine-based diagnostics principles, we conducted a review of Chinese literature regarding UPE with respect to a systems view of diagnostics. Data were summarized from human clinical studies and animal models published from 1979 through 1998. The...article 2016
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Jedynska, A. (author), Hoek, G. (author), Wang, M. (author), Eeftens, M. (author), Cyrys, J. (author), Beelen, R. (author), Cirach, M. (author), De Nazelle, A. (author), Keuken, M. (author), Visschedijk, A. (author), Nystad, W. (author), Akhlaghi, H.M. (author), Meliefste, K. (author), Nieuwenhuijsen, M. (author), de Hoogh, K. (author), Brunekreef, B. (author), Kooter, I.M. (author)Relatively little is known about long term effects of wood smoke on population health. A wood combustion marker - levoglucosan - was measured using a standardized sampling and measurement method in four European study areas (Oslo, The Netherlands, Munich/Augsburg, Catalonia) to assess within and between study area spatial variation. Levoglucosan...article 2015
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Beelen, R. (author), Hoek, G. (author), Raaschou-Nielsen, O. (author), Stafoggia, M. (author), Andersen, Z.J. (author), Weinmayr, G. (author), Hoffmann, B. (author), Wolf, K. (author), Samoli, E. (author), Fischer, P.H. (author), Nieuwenhuijsen, M.J. (author), Xun, W.W. (author), Katsouyanni, K. (author), Dimakopoulou, K. (author), Marcon, A. (author), Vartiainen, E. (author), Lanki, T. (author), Yli-Tuomi, T. (author), Oftedal, B. (author), Schwarze, P.E. (author), Nafstad, P. (author), de Faire, U. (author), Pedersen, N.L. (author), Östenson, C.-G. (author), Fratiglioni, L. (author), Penell, J. (author), Korek, M. (author), Pershagen, G. (author), Eriksen, K.T. (author), Overvad, K. (author), Sørensen, M. (author), Eeftens, M. (author), Peeters, P.H. (author), Meliefste, K. (author), Wang, M. (author), Bas Bueno-De-Mesquita, H. (author), Sugiri, D. (author), Krämer, U. (author), Heinrich, J. (author), De Hoogh, K. (author), Key, T. (author), Peters, A. (author), Hampel, R. (author), Concin, H. (author), Nagel, G. (author), Jaensch, A. (author), Ineichen, A. (author), Tsai, M.-Y. (author), Schaffner, E. (author), Probst-Hensch, N.M. (author), Schindler, C. (author), Ragettli, M.S. (author), Vilier, A. (author), Clavel-Chapelon, F. (author), Declercq, C. (author), Ricceri, F. (author), Sacerdote, C. (author), Galassi, C. (author), Migliore, E. (author), Ranzi, A. (author), Cesaroni, G. (author), Badaloni, C. (author), Forastiere, F. (author), Katsoulis, M. (author), Trichopoulou, A. (author), Keuken, M. (author), Jedynska, A. (author), Kooter, I.M. (author), Kukkonen, J. (author), Sokhi, R.S. (author), Vineis, P. (author), Brunekreef, B. (author)Background: Studies have shown associations between mortality and long-term exposure to particulate matter air pollution. Few cohort studies have estimated the effects of the elemental composition of particulate matter on mortality. oBjectives: Our aim was to study the association between natural-cause mortality and long-term exposure to...article 2015
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Tsai, M.Y. (author), Hoek, G. (author), Eeftens, M. (author), de Hoogh, K. (author), Beelen, R. (author), Beregszászi, T. (author), Cesaroni, G. (author), Cirach, M. (author), Cyrys, J. (author), de Nazelle, A. (author), de Vocht, F. (author), Ducret-Stich, R. (author), Eriksen, K. (author), Galassi, C. (author), Gražuleviciene, R. (author), Gražulevicius, T. (author), Grivas, G. (author), Gryparis, A. (author), Heinrich, J. (author), Hoffmann, B. (author), Iakovides, M. (author), Keuken, M. (author), Krämer, U. (author), Künzli, N. (author), Lanki, T. (author), Madsen, C. (author), Meliefste, K. (author), Merritt, A.S. (author), Mölter, A. (author), Mosler, G. (author), Nieuwenhuijsen, M.J. (author), Pershagen, G. (author), Phuleria, H. (author), Quass, U. (author), Ranzi, A. (author), Schaffner, E. (author), Sokhi, R. (author), Stempfelet, M. (author), Stephanou, E. (author), Sugiri, D. (author), Taimisto, P. (author), Tewis, M. (author), Udvardy, O. (author), Wang, M. (author), Brunekreef, B. (author)An increasing number of epidemiological studies suggest that adverse health effects of air pollution may be related to particulate matter (PM) composition, particularly trace metals. However, we lack comprehensive data on the spatial distribution of these elements.We measured PM<inf>2.5</inf> and PM<inf>10</inf> in twenty study areas across...article 2015
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He, M. (author), van Wijk, E. (author), Berger, R. (author), Wang, M. (author), Strassburg, K. (author), Schoeman, J.C. (author), Vreeken, R.J. (author), van Wietmarschen, H. (author), Harms, A.C. (author), Kobayashi, M. (author), Hankemeier, T. (author), van der Greef, J. (author)Oxylipins play important roles in various biological processes and are considered as mediators of inflammation for a wide range of diseases such as rheumatoid arthritis (RA). The purpose of this research was to study differences in oxylipin levels between a widely used collagen induced arthritis (CIA) mice model and healthy control (Ctrl) mice....article 2015
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Zhang, Y. (author), Verhoeff, N.I. (author), Chen, Z. (author), Chen, S. (author), Wang, M. (author), Zhu, Z. (author), Ouwerkerk, P.B.F. (author)Relative little is known about the functions of the so-called Dof zinc factors in plants. Here we report on the analysis of OsDof25 and show a function in regulation of the important C4 photosynthesis gene, OsC4PPDK in rice. Over-expression of OsDof25 enhanced the expression of OsC4PPDK in transient expression experiments by binding in a...article 2015
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Jedynska, A. (author), Hoek, G. (author), Wang, M. (author), Eeftens, M. (author), Cyrys, J. (author), Keuken, M. (author), Ampe, C. (author), Beelen, R. (author), Cesaroni, G. (author), Forastiere, F. (author), Cirach, M. (author), de Hoogh, K. (author), de Nazelle, A. (author), Nystad, W. (author), Declercq, C. (author), Eriksen, K.T. (author), Dimakopoulou, K. (author), Lanki, T. (author), Meliefste, K. (author), Nieuwenhuijsen, M.J. (author), Yli-Tuomi, T. (author), Raaschou-Nielsen, O. (author), Brunekreef, B. (author), Kooter, I.M. (author)Land use regression (LUR) models have been used to model concentrations of mainly traffic-related air pollutants (nitrogen oxides (NOx), particulate matter (PM) mass or absorbance). Few LUR models are published of PM composition, whereas the interest in health effects related to particle composition is increasing. The aim of our study was to...article 2014