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Vreeken, D. (author), Seidel, F. (author), de La Roij, G. (author), Vening, W. (author), den Hengst, W.A. (author), Verschuren, L. (author), Özsezen, S. (author), Kessels, R.P.C. (author), Duering, M. (author), Mutsaerts, H.J.M.M. (author), Kleemann, R. (author), Wiesmann, M. (author), Hazebroek, E.J. (author), Kiliaan, A.J. (author)BACKGROUND AND OBJECTIVE: While underlying pathophysiology linking obesity to brain health is not completely understood, white adipose tissue (WAT) is considered a key player. In obesity, WAT becomes dysregulated, showing hyperplasia, hypertrophy, and eventually inflammation. This disbalance leads to dysregulated secretion of adipokines...article 2023
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Vreeken, D. (author), Wiesmann, M. (author), Deden, L.N. (author), Arnoldussen, I.A.C. (author), Aarts, E. (author), Kessels, R.P.C. (author), Kleemann, R. (author), Hazebroek, E.J. (author), Aarts, E.O. (author), Kiliaan, A.J. (author)Introduction Weight loss after bariatric surgery (BS) is often associated with improved cognition and structural brain recovery. However, improved cognition after BS is not always exhibited by patients, in fact, in some cases there is even a decline in cognition. Long-term consequences of BS weight loss, in terms of obesity and related diseases,...article 2019
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Jacobs, S.A.H. (author), Gart, E. (author), Vreeken, D. (author), Franx, B.A.A. (author), Wekking, L. (author), Verweij, V.G.M. (author), Worms, N. (author), Schoemaker, M.H. (author), Gross, G. (author), Morrison, M.C. (author), Kleemann, R. (author), Arnoldussen, I.A.C. (author), Kiliaan, A.J. (author)Background: Sex-specific differences play a role in metabolism, fat storage in adipose tissue, and brain structure. At juvenile age, brain function is susceptible to the effects of obesity; little is known about sex-specific differences in juvenile obesity. Therefore, this study examined sex-specific differences in adipose tissue and liver of...article 2019