Chemically-induced immunopathology and immune functional changes

Toxicological pathology of lymphoid organs plays an important role in the risk assessment process of immunotoxicants. Identification of chemicals that have the potential to cause injury to the immune system is of considerable public health significance because of the role of the immune system in infectious diseases, hypersensitivity reactions...

Immune system

Histopathologic approaches to detect changes indicative of immunotoxicity

Toxicologic pathology is crucial in the identification and characterization of health effects following exposure to xenobiotics, mainly in toxicity experiments in rodents. Regarding regulatory toxicology, histopathology of lymphoid organs and tissues is a cornerstone in the identification of immunotoxic compounds. A 2-tier testing system is...

Intestinal T lymphocytes of different rat strains in immunotoxicity

In order to study the intestinal mucosal immune cells, with emphasis on single T lymphocytcs, an inventory was made of single and organized lymphocytes in the epithelium and lamina propria of the small intestines of untreated Wistar, Fischer 344, and Lewis rats. The single and organized lymphocytes were examined microscopically. In addition, the...

Intestinal T lymphocytes of different rat strains in immunotoxicity

Lymphoid tissue architecture and pathological influences of toxicants

Immune effects of hexachlorobenzene in the rat: Role of metabolism in a 13-week feeding study

Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to the human thymus after implantation in SCID mice

Pathology in immunotoxicology

Time course of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced thymic atrophy in the Wistar rat

The role of oxidative metabolism in hexachlorobenzene-induced porphyria and thyroid hormone homeostasis: a comparison with pentachlorobenzene in a 13-week feeding study

Hexachlorobenzene (HCB) induces a broad spectrum of effects including disturbances in the heme synthesis (porphyria) and in thyroid hormone homeostasis. For most of its effects, biotransformation of the parent compound seems to be a prerequisite. The present study was designed to assess the relevance of the oxidative metabolites in HCB-induced...

Normal development, growth and aging of the thymus

Antitumor activity, induction of cross-resistance, and nephrotoxicity of a new platinum analogue, cis-1,1-diaminomethylcyclohexaneplatinum(II) sulfate, and of cis-diamminedichloroplatinum(II) in and immunocytoma model in the LOU/M rat

Toxicology of polychlorinated biphenyls (PCB's) and impurities.

Identification and toxicological evaluation of chlorinated dibenzofuran and chlorinated naphthalene in two commercial polychlorinated biphenyls

In a previous study (Vos & Koeman, Toxic. appl. Pharmac. 1970. In press) a significant difference in toxicity was found between three commercial polychlorinated biphenyl (PCB) preparations, high mortality, liver necrosis and chick oedema-like lesions being associated with only two of the compounds tested. In the present study, column and gas...