document

Machine learning to improve false-positive results in the Dutch newborn screening for congenital hypothyroidism

Stroek, K. (author), Visser, A. (author), van der Ploeg, C.P.B. (author), Zwaveling-Soonawala, N. (author), Heijboer, A.C. (author), Bosch, A.M. (author), van Trotsenburg, P. (author), Boelen, A. (author), Hoogendoorn, M. (author), de Jonge, R. (author)

Objective. The Dutch Congenital hypothyroidism (CH) Newborn Screening (NBS) algorithm for thyroidal and central congenital hypothyroidism (CH-T and CH-C, respectively) is primarily based on determination of thyroxine (T4) concentrations in dried blood spots, followed by thyroid-stimulating hormone (TSH) and thyroxine-binding globulin (TBG)...

article 2023

document

Organization and activities of school health services among EU countries

Michaud, P.A. (author), Vervoort, J.P.M. (author), Visser, A. (author), Baltag, V. (author), Reijneveld, S.A. (author), Kocken, P. (author), Jansen, D.E.M.C. (author)

Background: School health services (SHS) can be defined as health services provided to enrol pupils by health professionals and/or allied professions. The aim of this study was to explore the current state of the governance, organization and workforce of SHS and their provision of preventive activities in European countries. Methods:...

article 2021

document

Do European Union countries adequately address the healthcare needs of adolescents in the area of sexual reproductive health and rights?

Michaud, P.A. (author), Visser, A. (author), Vervoort, J.P.M. (author), Kocken, P. (author), Reijneveld, S.A. (author), Blair, M. (author), Rigby, M. (author), Weber, M. (author), Jansen, D. (author)

Background and objectives Adolescent sexual and reproductive health and rights (SRHR) are of particular relevance given their potential short-term or long-term health consequences. This study evaluates recommendations and policies regarding access to care in this area in 31 European countries (European Union (EU) plus Iceland, Norway and...

article 2020

document

Availability and accessibility of primary mental health services for adolescents: an overview of national recommendations and services in EU

Michaud, P.A. (author), Visser, A. (author), Vervoort, J.P.M. (author), Kocken, P. (author), Reijneveld, S.A. (author), Jansen, D.E.M.C. (author)

BACKGROUND: Mental health problems in adolescence can profoundly jeopardize adolescent current and future health and functioning. We aimed to describe existing recommendations and services regarding the delivery of primary mental health care for adolescents in 31 European countries. METHODS: Data on the availability and accessibility of primary...

article 2020

document

School health services

Jansen, D. (author), Vervoort, J.P.M. (author), Visser, A. (author), Reijneveld, S.A. (author), Kocken, P. (author), de Lijster, G. (author), Michaud, P.A. (author)

MOCHA defines school health services as those that exist due to a formal arrangement between educational institutions and primary health care. School health services are unique in that they are designed exclusively to address the needs of children and adolescents in this age group and setting. We investigated school health services have been...

bookPart 2019

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High-frequency monitoring of water fluxes and nutrient loads to assess the effects of controlled drainage on water storage and nutrient transport

Rozemeijer, J.C. (author), Visser, A. (author), Borren, W. (author), Winegram, M. (author), van der Velde, Y. (author), Klein, J. (author), Broers, H.P. (author)

High nitrogen (N) and phosphorus (P) fluxes from upstream agriculture threaten aquatic ecosystems in surface waters and estuaries, especially in areas characterized by high agricultural N and P inputs and densely drained catchments like the Netherlands. Controlled drainage has been recognized as an effective option to optimize soil moisture...

article 2016

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A Bayesian modeling approach for estimation of a shape-free groundwater age distribution using multiple tracers

Massoudieh, A. (author), Visser, A. (author), Sharifi, S. (author), Broers, H.P. (author)

Due to the mixing of groundwaters with different ages in aquifers, groundwater age is more appropriately represented by a distribution rather than a scalar number. To infer a groundwater age distribution from environmental tracers, a mathematical form is often assumed for the shape of the distribution and the parameters of the mathematical...

article 2014

document

Climate change impacts on the leaching of a heavy metal contamination in a small lowland catchment

Visser, A. (author), Kroes, J. (author), van Vliet, M.T.H. (author), Blenkinsop, S. (author), Fowler, H.J. (author), Broers, H.P. (author)

The Keersop catchment (43 km2) in the south of The Netherlands has been contaminated by the emissions of four zinc ore smelters. The objective of this study was to assess the effects of future projected climate change on the hydrology and the leaching of heavy metals (i.e. Cd and Zn) in the catchment. The numerical, quasi-2D, unsaturated zone...

article 2012

document

Degassing of 3H/3He, CFCs and SF6 by denitrification: Measurements and two-phase transport simulations

Visser, A. (author), Schaap, J.D. (author), Broers, H.P. (author), Bierkens, M.F.P. (author), TNO Bouw en Ondergrond (author)

The production of N2 gas by denitrification may lead to the appearance of a gas phase below the water table prohibiting the conservative transport of tracer gases required for groundwater dating. We used a two-phase flow and transport model (STOMP) to study the reliability of 3H/3He, CFCs and SF6 as groundwater age tracers under agricultural...

article 2009

document

Comparison of methods for the detection and extrapolation of trends in groundwater quality

Visser, A. (author), Dubus, I. (author), Broers, H.P. (author), Brouyère, S. (author), Korcz, M. (author), Orban, P. (author), Goderniaux, P. (author), Batlle-Aguilar, J. (author), Surdyk, N. (author), Amraoui, N. (author), Job, H. (author), Pinault, J.L. (author), Bierkens, M. (author), TNO Bouw en Ondergrond (author)

Land use changes and the intensification of agriculture since the 1950s have resulted in a deterioration of groundwater quality in many European countries. For the protection of groundwater quality, it is necessary to (1) assess the current groundwater quality status, (2) detect changes or trends in groundwater quality, (3) assess the threat of...

article 2009

document

Modelling two-phase transport of 3H/3He

Visser, A. (author), Schaap, J.D. (author), Leijnse, T. (author), Broers, H.P. (author), Bierkens, M.F.P. (author), TNO Bouw en Ondergrond (author)

Degassing of groundwater by excess denitrification of agricultural pollution complicates the interpretation of 3H/3He data and hinders the estimation of travel times in nitrate pollution studies. In this study we used a two-phase flow and transport model (STOMP) to evaluate the method presented by Visser (2007a) to interpret degassed 3H/ 3He...

conference paper 2008

document

Dating degassed groundwater with 3H/3He

Visser, A. (author), Broers, H.P. (author), Bierkens, M.F.P. (author), TNO Bouw en Ondergrond (author)

The production of gases in groundwater under contaminated locations by geochemical and biological processes is not uncommon. Degassing of these gases from groundwater and repartitioning of noble gases between water and gas phase distorts groundwater dating by 3H/3He. We observed noble gas concentrations below atmospheric equilibrium in 20 out of...

article 2007

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Demonstrating trend reversal of groundwater quality in relation to time of recharge determined by 3H/3He

Visser, A. (author), Broers, H.P. (author), van der Grift, B. (author), Bierkens, M.F.P. (author), TNO Bouw en Ondergrond (author)

Recent EU legislation is directed to reverse the upward trends in the concentrations of agricultural pollutants in groundwater. However, uncertainty of the groundwater travel time towards the screens of the groundwater quality monitoring networks complicates the demonstration of trend reversal. We investigated whether trend reversal can be...

article 2007

document

Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation

van Bezooijen, R.L. (author), Svensson, J.P. (author), Eefting, D. (author), Visser, A. (author), van der Horst, G. (author), Karperien, M. (author), Quax, P.H.A. (author), Vrieling, H. (author), Papapoulos, S.E. (author), ten Dijke, P. (author), Löwik, W.G.M.C. (author), TNO Kwaliteit van Leven (author)

Sclerostin is an osteocyte-derived negative regulator of bone formation. It inhibits BMP-stimulated bone formation both in vitro and in vivo but has no direct effect on BMP signaling. Instead, sclerostin inhibits Wnt signaling that is required for BMP-stimulated osteoblastic differentiation. Introduction: Sclerostin is a member of the Dan family...

article 2007

document

Young people and sex: Behaviour and health risks in Dutch school students

Vogels, T. (author), van der Vliet, R. (author), Danz, M. (author), Hopman-Rock, M. (author), Visser, A. (author), TNO Preventie en Gezondheid (author)

article 1993

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Seksueel gedrag en gezondheidsrisico's van leerlingen in het voortgezet onderwijs

Nederlands Instituut voor Praeventieve Gezondheidszorg TNO Nederlandse Organisatie voor Toegepast-Natuurwetenschappelijk Onderzoek Hoofdgroep Gezondheidsonderzoek (author), Visser, A. (author), Hopman-Rock, M. (author)

Enkele resultaten uit het Peilstationonderzoek Gezondheid, gedrag en relaties, ten behoeve van leerkrachten en leerlingen.

other 1990

document

Het gebruik van vragenlijsten in de adolescentenzorg vanuit de JGZ ; verslag van een telefonische enquête

TNO Preventie en Gezondheid Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author), Vogels, T. (author), Andries, F. (author), Danz, M. (author), Kuiper, T. (author), Visser, A. (author)

report 1988

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Boven de norm; een inventarisatie van aktiviteiten vanuit de JGZ ten behoeve van oudere adolescenten

Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author), Vogels, T. (author), Visser, A. (author), Andries, F. (author)

report 1987

document

Adolescenten en de jeugdgezondheidszorg; Een samenvatting gericht op konklusies en aanbevelingen

Nederlands Instituut voor Praeventieve Gezondheidszorg TNO TNO Preventie en Gezondheid (author), Andries, F. (author), Schuurman, M. (author), Visser, A. (author), Vogels, T. (author)

report 1985

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Adolescenten en de jeugdgezondheidszorg; Onderzoek onder oudere adolescenten in Zuid-Oost Drenthe (incl. Emmen deel 3)

Nederlands Instituut voor Praeventieve Gezondheidszorg TNO TNO Preventie en Gezondheid (author), Andries, F. (author), Schuurman, M. (author), Visser, A. (author), Vogels, T. (author)

report 1985