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Appel, M.J. (author), van Veen, H.A. (author), Vietsch, H. (author), Salaheddine, M. (author), Nuijens, J.H. (author), Ziere, B. (author), de Loos, F. (author), TNO Kwaliteit van Leven (author)The oral toxicity of recombinant human lactoferrin (rhLF) produced in the milk of transgenic cows was investigated in Wistar rats by daily administration via oral gavage for 13 consecutive weeks, 7 days per week. The study used four groups of 20 rats/sex/dose. The control group received physiological saline and the three test groups received...article 2006
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Kuiper, J. (author), van Teijlingen, M. (author), Vietsch, H. (author), Rijken, D.C. (author), van Berkel, T.J.C. (author), Blessen, E.A.L. (author), Division of Biopharmaceutics, LACDR, Leiden, Netherlands Gaubius Laboratory TNO Preventie en Gezondheid (author)A major complication of the use of of tissue-type plasminogen activator (t-PA) as fibrinolytic agent is its rapid clearance from the bloodstream. We have studied whether t-PA clearance can be reduced by preventing receptor-mediated endocytosis of t-PA in vivo via the mannose receptor and the low-density lipoprotein receptor related protein (LRP)...article 1996
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Biessen, E.A.L. (author), Kuiper, J. (author), van Teijlingen, M. (author), Vietsch, H. (author), Bijsterbosch, M.K. (author), Rijken, D.C. (author), van Berkel, T.J.C. (author), Gaubius Instituut TNO (author)Abstractarticle 1995