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TNO Preventie en Gezondheid (author), Bayley, J.P. (author), Bakker, A.M. (author), Kaijzel, E.L. (author), Huizinga, T.W.J. (author), Verweij, C.L. (author)Objective. To assess the role of polymorphisms of the tumour necrosis factor (TNF) receptors, TNF-RI (p55) and TNF-RII (p75) in the susceptibility to and severity of rheumatoid arthritis (RA) in Dutch patients. Methods. A total of 319 consecutive RA patients, and a cohort of 90 female RA patients with detailed 12-yr follow-up were genotyped for...article 2003
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TNO Preventie en Gezondheid (author), Bayley, J.P. (author), Bakker, A.M. (author), Kaijzel, E.L. (author), Wierenga, E.A. (author), van der Pouw-Kraan, T.C.T.M. (author), Huizinga, T.W.J. (author), Verweij, C.L. (author)The occurrence of monoallelic expression of cytokine genes in single cells has been convincingly demonstrated, but there have been few reports of this phenomenon in T cell clones. Here we describe studies on the expression of alleles of the human genes encoding IL-2, IL-3, IL-4, and IL-13 in human CD4+ T cell clones. In contrast to the results...article 2003
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Gaubius Instituut TNO (author), Bayley, J.P. (author), van Rietschoten, J.G.I. (author), Bakker, A.M. (author), van Baarsen, L. (author), Kaijzel, E.L. (author), Wierenga, E.A. (author), van der pouw Kraan, T.C.T.M. (author), Huizinga, T.W.J. (author), Verweij, C.L. (author)A number of reports have described the monoallelic expression of murine cytokine genes. Here we describe the monoallelic expression of the human IL-1? gene in CD4+ T cells. Analysis of peripheral blood T cell clones derived from healthy individuals revealed that the IL-1? gene shows predominantly monoallelic expression. Monoallelic expression...article 2003
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van Boxel-Dezaire, A.H.H. (author), Hoff, S.C.J. (author), van Oosten, B.W. (author), Verweij, C.L. (author), Dräger, A.M. (author), Adèr, H.J. (author), van Houwelingen, J.C. (author), Barkhof, F. (author), Polman, C.H. (author), Nagelkerken, L. (author), TNO Preventie en Gezondheid (author)It has been shown that proinflammatory and antiinflammatory cytokines correlate with disease activity in multiple sclerosis (MS). To establish whether such correlations depend on the disease stage, we assessed in a longitudinal fashion the expression of interleukin (IL)-12 (p40 and p35), tumor necrosis factor- 1/4 , interferon-γ, and IL-10 mRNA...article 1999
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Feltkamp, T.E.W. (author), Aarden, L.A. (author), Lucas, C.J. (author), Verweij, C.L. (author), de Vries, R.R.P. (author), TNO Preventie en Gezondheid (author)In most autoimmune diseases multigenic factors play a significant role in pathogenesis. Progress in identifying these genetic factors, many of which are located outside the major histocompatibility complex, was the subject of a recent meeting. Chemicals/CAS: Interleukin-10, 130068-27-8; Transforming Growth Factor beta; Tumor Necrosis Factor-alphaarticle 1999