The effect of chitosan on the bioaccessibility and intestinal permeability of acyclovir

Evaluation of two dynamic in vitro models simulating fasted and fed state conditions in the upper gastrointestinal tract (TIM-1 and tiny-TIM) for investigating the bioaccessibility of pharmaceutical compounds from oral dosage forms

Prediction of in vivo developmental toxicity of all-trans-retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling

Predicting carrier-mediated hepatic disposition of rosuvastatin in man by scaling from individual transfected cell-lines in vitro using absolute transporter protein quantification and PBPK modeling.

In vitro models for the prediction of in vivo performance of oral dosage forms

A new approach to predict human intestinal absorption using porcine intestinal tissue and biorelevant matrices

Prediction of in vivo developmental toxicity of all‑trans‑retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling

Drug-drug interactions between rosuvastatin and oral antidiabetic drugs occurring at the level of oatp1b1s

Human embryonic stem cell-derived test systems for developmental neurotoxicity: A transcriptomics approach

Integrated testing strategy for reproductive toxicity

Toward in vitro biomarkers for developmental toxicity and their extrapolation to the in vivo situation

Relative developmental toxicity potencies of retinoids in the embryonic stem cell test compared with their relative potencies in in vivo and two other in vitro assays for developmental toxicity

Decrease of intracellular pH as possible mechanism of embryotoxicity of glycol ether alkoxyacetic acid metabolites

The use of in vitro toxicity data and physiologically based kinetic modeling to predict dose-response curves for in vivo developmental toxicity of glycol ethers in rat and man

Physiologically based pharmacokinetic modeling of cyclohexane as a tool for integrating animal and human test data

A review of the implementation of the embryonic stem cell test (EST)

Relative developmental toxicity of glycol ether alkoxy acid metabolites in the embryonic stem cell test as compared with the in vivo potency of their parent compounds

Model studies for evaluating the neurobehavioral effects of complex hydrocarbon solvents. III. PBPK modeling of white spirit constituents as a tool for integrating animal and human test data

Development of a QSAR for worst case estimates of acute toxicity of chemically reactive compounds

Prediction of in vivo embryotoxic effect levels with a combination of in vitro studies and PBPK modelling