Human biomonitoring in health risk assessment in Europe: Current practices and recommendations for the future

Human biomonitoring (HBM) is an important tool to survey the internal exposure of humans which represents the real life chemical body burden to chemicals and/or their metabolites. It results from total exposure to chemical substances from different sources and via different routes. These substances may be regulated under different legislative...

OSIRIS, a quest for proof of principle for integrated testing strategies of chemicals for four human health endpoints

Chemical substances policies in Europe are aiming towards chemical safety and at the same time a reduction in animal testing. These goals are alleged to be reachable by mining as many relevant data as possible, evaluate these data with regard to validity, reliability and relevance, and use of these data in so-called Integrated Testing Strategies...

A probabilistic human health risk assessment for environmental exposure to dibutylphthalate

Probabilistic assessment factors for human health risk assessment. A practical guide

Assessment factors for human health risk assessment: A discussion paper

Assessment factors for human health risk assessment: A discussion paper

The general goal of this discussion paper is to contribute toward the further harmonization of human health risk assessment. It first discusses the development of a formal, harmonized set of assessment factors. The status quo with regard to assessment factors is reviewed, that is, the type of factors to be identified, the range of values...

Risk assessment and management of new and existing chemicals

An evaluation was made of the recently developed risk assessment methodologies for new and existing chemicals in the European Communities. The evaluation also included the methodologies to prioritize chemicals and procedures for risk management, i.e., the (draft) guidance document for the development of strategies for risk reduction. The way in...